Kidney stones and crushed bones secondary to hyperparathyroidism.

Here we report a 65-year-old woman with multiple brown tumors and renal stones secondary to primary hyperparathyroidism. This case highlights the need for early recognition of parathyroid hyperactivity.

Ewing's Sarcoma of the Cranial Vault.

Primary Ewing's sarcoma (EWS) arising from cranial bones is rare and accounts for only 1%-4% of all EWS. We report the case of a 15-year-old girl with EWS of the frontoparietal region of the skull. She underwent excision following which she received combination chemotherapy with vincristine, doxorubicin, cyclophosphamide alternating with ifosfamide, and VP16 and local radiation of 45 Gy. She is alive in complete remission at 40 months.

Osteolytic Bone Lesions - A Rare Presentation of AML M6.

Acute myeloid leukemia (AML) M6 is a rare form of AML accounting for < 5 % of all AML. Extramedullary involvement is very rarely seen in this entity. Skeletal lesion has not been described in AML M6 before. We discuss the case of a 17 year old boy with AML M6, who presented with osteolytic lesion of right humerus. He was treated with induction and consolidation chemotherapy. The present case is the first report in literature of AML M6 presenting with skeletal lesions.

Burkitt's lymphoma of the humerus.

Burkitt's lymphoma is an uncommon form of non-Hodgkin's lymphoma (NHL) in adults and represents < 5% of NHL adults. Burkitt's lymphoma involving primarily the appendicular skeleton is rarely described. We present the case of a young man with primary Burkitt's lymphoma involving the humerus as the only site of disease. He received R hyper CVAD and local irradiation and is in complete remission at 24 months.

Primary splenic sarcoidosis.

Here we report a case of primary splenic sarcoidosis presenting with isolated splenomegaly with multiple splenic nodules. The sarcoidosis was diagnosed and treated by splenectomy.

Anaplastic large cell lymphoma presenting as a cerebellar mass.

Anaplastic large cell lymphoma (ALCL) is a T cell lymphoma occurring commonly in childhood and rarely in adults. Central nervous system involvement in ALCL is very rare and cerebellar involvement at presentation has never been described. We examine the case of a young adult who presented with a cerebellar mass. A 19-year-old boy presented with signs of raised intracranial tension, which, on imaging, revealed a right cerebellar mass. He underwent suboccipital craniotomy and partial excision of the tumor. However, the histopathology was inconclusive. He subsequently presented with cerebellar signs and repeat imaging showed recurrence of the cerebellar lesion. He underwent decompression and ventriculoperitoneal (VP) shunting. Histopathology was suggestive of ALK (anaplastic lymphoma kinase) positive anaplastic large cell lymphoma. The patient was started on chemotherapy. However, his neurological status deteriorated, his condition worsened, and he expired a month later.