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Ren Fail ; 34(7): 880-4, 2012.
Article in English | MEDLINE | ID: mdl-22680304

ABSTRACT

We studied paraphenylenediamine (PPD)-related acute kidney injury (AKI) in 81 patients and also in albino rats experimentally. In the patients' group AKI was found in 32.7%. Of them, 81.4% needed dialysis support. The overall mortality was 25.9%. In experimental rats the renal lesions were noted in all and they were glomerular congestion, intertubular (interstitial) hemorrhages, acute tubular necrosis, mesangial proliferation, and intratubular casts. The severity of renal injury appears to be dose dependent.


Subject(s)
Acute Kidney Injury/chemically induced , Hair Dyes/poisoning , Phenylenediamines/poisoning , Acute Kidney Injury/pathology , Adult , Animals , Female , Humans , Kidney/pathology , Male , Middle Aged , Rats , Young Adult
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