Biofunctionalization of titanium implants with a biomimetic active peptide (P-15) promotes early osseointegration.

OBJECTIVES: The early stages of peri-implant bone formation play an essential role in the osseointegration and long-term success of dental implants. By incorporating bioactive coatings, this biofunctionalization of implant surfaces may enhance the attachment of the implant to the surrounding bone and stimulate bone regeneration. MATERIAL AND METHODS: To demonstrate faster osseointegration, the surfaces of dental implants were grit-blasted and acid-etched. They were then coated with hydroxyapatite (HA) and experimental implants were further coated with a biomimetic active peptide (P-15) in one of two concentrations. These biofunctionalized samples and controls with no peptide were placed in the forehead region of 12 adult pigs. Six animals were evaluated for a period of 14 or 30 days. RESULTS: Histomorphometric analysis demonstrated that the implants with the high concentration of P-15 had significantly higher percentage of bone-to-implant contact (BIC) at 14 (P=0.018) and 30 (P=0.015) days compared with the other groups. Both concentrations of P-15 showed increased peri-implant bone density compared to the control group at 30 days. CONCLUSION: Biofunctionalization of the implant surface with a biomimetic active peptide leads to significantly increased BIC rates at 14 and 30 days and higher peri-implant bone density at 30 days.

Evaluation of substitutes for bone: comparison of microradiographic and histological assessments.

We created defects of standard size in the frontal bones of adult pigs and filled them with four different materials. On six occasions (at 1, 2, 4, 8, 12, and 26 weeks), samples were harvested, and evaluated by computing microradiographic images. We examined the specimens histologically as controls. After insertion of anorganic materials, microradiographic evaluation was easy and precise, and there were no significant differences between them and the histological controls (p=0.2). A quantitative evaluation of chemically sterilised bone by computer was not possible for more than 4 weeks.

Epidemiology of HIV infection among Israeli Arabs.

OBJECTIVE: Israeli Arab citizens comprise Israel's largest minority group (15.6% of Israelis>12 years old). The objectives of this study were to describe the epidemiology of human immunodeficiency virus (HIV) in this group for the first time at a national level, and to identify health promotion and treatment needs. METHODS: All HIV/acquired immunodeficiency syndrome (AIDS) cases among Israeli Arab citizens that were notified to the Ministry of Health between 1985 and 2002 were analysed and compared with other Israelis (excluding immigrants from sub-Saharan Africa and their children). RESULTS: Twenty-five AIDS cases and 51 HIV-positive cases were notified in adult/adolescent Israeli Arabs, (3.4% of all adult/adolescent cases). In addition, four child cases were reported. The cumulative rates for Arab and non-Arab Israelis were 10.1 and 37.8/100,000, respectively. The gender ratios (male/female) were 3.3 and 4.4 for AIDS cases and HIV cases, respectively. The median age was 31.5 years [interquartile range (IQR)=12] for AIDS cases and 30 (IQR=12) for HIV cases. Modes of transmission were heterosexual contact (34%), intravenous drug use (21%), male homosexual contact (19%), unknown (14%), haemophilia (6%), children of at-risk parents (4%) and blood (2%). The mean interval from HIV notification to AIDS diagnosis was 1.5 years until 1998 and 2.8 years thereafter. Knowledge, attitudes and practices studies on AIDS in Arabs are also discussed in this article. CONCLUSION: HIV prevalence is lower in Arab Israelis than in non-Arab Israelis and Arabs residing in neighbouring countries. Nevertheless, the shorter interval from HIV notification to AIDS diagnosis in Arab Israelis suggests a lower rate of HIV testing and diagnosis at a later stage of infection. Patterns of transmission in Arab Israelis need further evaluation, including behavioural surveys.

[Cerebral abscess and cyanotic congenital heart disease]. / Abcès cérébraux et cardiopathies congénitales cyanogènes.

Cerebral abscess is a classical complication of cyanotic congenital heart disease. The authors report 7 cases of cerebral abscess diagnosed since 1982. One asymptomatic patient died of a postoperative cerebral haemorrage. The child was repatriated from Africa for complete correction of his cardiac lesion. The presentation of the other 6 cases was quite typical : headaches, pyrexia and vomiting with a neurological deficit in 4 cases : two hemiparesias and two homonymous lateral hemianopsia. These 6 patients recovered without sequeilae. Four underwent surgical drainage of the abscess with antibiotic therapy. Two recovered with antibiotic therapy alone. The causal organism was only identified in patients undergoing surgical drainage and then only in 3 cases. They were gram positive cocci, in particular the streptococcus. The association ampicillin-chloramphenicol has often been proposed as the treatment of first intention. Adaptation of antibiotic therapy then depends on clinical, biological, bacteriological (CSF, blood cultures, portal of entry) outcomes and the results of CT scanning. The association of a third generation cephalosporin and an imidazole may be proposed as treatment of second intention. The minimal duration of treatment is generally acknowledged to be 4 weeks for intravenous therapy in cases of medical therapy alone, and 2 to 3 weeks in cases with surgical drainage. The age of apparition of this complication seems to be increasing as the average age was 16 in this series (cerebral abscess is classically described as occurring between 8 and 12 years of age). This may be due to palliative surgery which reduces systemic hypoxia and polycythaemia. It also appears that neurological drainage is not systematic now because of early diagnosis of this complication. Finally, in the last few years, a new population of patients is becoming more common : patients repatriated by humanitary organisations in the third world, which should incite great vigilance in the preoperative period in this pathology.

[Percutaneous dilatation of the pulmonary tract in tetralogy of Fallot]. / Dilatation percutanée de la voie pulmonaire dans la tétralogie de Fallot.

When palliative treatment is indicated in tetralogy of Fallot, percutaneous endoluminal dilatation of the valvular pulmonary stenosis may represent an alternative to palliative surgery (systemico-pulmonary shunt) and its disadvantages. This paper sets out the clinical outcome and growth of the pulmonary arterial circulation after dilatation of the valvular pulmonary stenosis in children with tetralogy of Fallot. Twenty-five children (average age: 8 +/- 5.8 week; average weight: 6.7 +/- 2.4 kg) were included in this study. The dilatation resulted in an immediate decrease in the patients' cyanosis and a significant increase (+10%) in arterial oxygen saturation. However, this technique did not suppress the risk of anoxic malaise. Only 5 children (20%) required a palliative surgical shunt for persistence of anoxic malaise. From the anatomical point of view, the dilatation induced significant growth of the pulmonary annulus (7.6 mm vs 11.3 mm; p < 0.0001), of the main pulmonary artery (6.8 mm vs 10 mm); p = 0.008) and left pulmonary artery (7 mm vs 11 mm; p = 0.02). The need for a procedure to widen the right ventricular outflow tract at the time of complete correction was also reduced. The perioperative mortality of complete correction and postoperative pulmonary insufficiency were decreased. Percutaneous dilatation of the right ventricular outflow tract is therefore a valuable palliative alternative to surgical sytemico-pulmonary shunt.

Review of the long-term course of 52 patients with pulmonary atresia and ventricular septal defect. Anatomical and surgical considerations.

This study reviews the long-term course of 52 patients with pulmonary atresia and ventricular septal defect seen in a single institution and followed for a mean period of 8.6 years (range 2 days to 20 years). Before the first operation, pulmonary blood supply was provided by ductus arteriosus supplying confluent pulmonary arteries in 26 patients (50%, group I), and was partially or entirely dependent on systemic collateral arteries in the other 26 patients (group II). The angiographic mean ratio of diameters of the right and left pulmonary artery/descending aorta (McGoon ratio) was significantly lower in group II than in group I, 0.76 +/- 0.42 vs 1.04 +/- 0.17 (P = 0.006). Severe arborization defects (with fewer than 10 pulmonary vascular segments connected to central pulmonary arteries) were present only in group II patients (eight patients: 15%), six of whom had congenital absence of the central pulmonary arteries. Corrective surgery was performed in 23 patients (44%, 14 in group I, nine in group II). All but one, who died later, had a McGoon ratio > or = 1 (mean 1.19 +/- 0.18) at time of repair. There was one hospital death (4%) and two late deaths (9%). All but one of the surviving corrected patients were in functional class I or II. Conduit replacement reoperation was performed in three patients (14%), 6, 10 and 13 years, respectively, after repair. At the end of the study, among the 37 patients (71%) who were alive (17 in group I, 20 in group II), 20 (39%) were corrected (12 in group I, eight in group II), four await corrective surgery, and six (11.5%) are estimated inoperable (all in group II) because of very hypoplastic or absent pulmonary arteries. This study confirms the estimated rate in the published literature of long-term survival in patients with pulmonary atresia and ventricular septal defect, and the good results of corrective surgery whenever the size and distribution of pulmonary arteries are satisfactory. The problem of very hypoplastic pulmonary arteries and severe arborization defects remains contentious.

[Comparative value of transthoracic echocardiography and angiography for measuring the pulmonary artery annulus in tetralogy of Fallot]. / Intérêt comparé de l'échographie transthoracique et de l'angiographie pour la mesure de l'anneau de l'artère pulmonaire dans la tétralogie de Fallot.

It may be necessary to perform an enlarging pulmonary annuloplasty during surgical cure of Tetralogy of Fallot (TOF) in order to optimise reconstruction of the right ventricular outflow tract. As this additional procedure implies an increase in perioperative mortality, it is useful to prepare for this eventuality before surgery. Two imaging techniques are available: transthoracic echocardiography (diameter of the pulmonary annulus obtained by averaging the measurements obtained in the subcostal and parasternal short axis views of the insertion of the pulmonary valve cusps at end systole) and selective angiography during right heart catheterisation (anteroposterior measurement with comparison to be projected and real size of the catheter at the point of insertion of the cusps at end systole). In this study, these two techniques were compared with reference to the peroperative measurement with Hegar dilators and criteria defined by Naito (minimal diameter of the pulmonary artery annulus with respect to the weight of the child). Seventy-eight children admitted to hospital between January 1986 and April 1994 for curative surgery of TOF were included. The calculation of the intra-class correlation coefficient showed a mediocre correlation with angiography and a very mediocre correlation with echocardiography compared with peroperative measurements. However, the calculation of sensitivities showed angiography to be the predictive investigation for annuloplasty in children not conforming to the Naito criteria: higher sensitivity (83% vs 26% for echocardiography), greater negative predictive value (84% vs 70%). This result holds for all categories of body weight (over and under 10 kg).(ABSTRACT TRUNCATED AT 250 WORDS)

[Antiphospholipid syndrome in children. Apropos of a case]. / Syndrome antiphospholipide chez l'enfant. A propos d'un cas.

The authors report the case of a 10 year old child who presented with an uncomplicated deep venous thrombosis associated with an antiphospholipid syndrome. The diagnosis was established by the finding of spontaneous prolongation of the activated cephalin time, the finding of a lupus-like antibody and an anti-cardiolipin antibody. The clinical outcome was good with oral anticoagulants but a recurrence was observed when they were stopped. The authors discuss the question of the duration of preventive therapy.

[What attitude should be adopted in congenital heart disease in adults?]. / Quelle attitude adopter devant une cardiopathie congénitale de l'adulte?

Two types of congenital heart disease are observed in adults: those discovered during childhood which may or may not have been operated, depending on their degree of severity and the surgical possibilities; those discovered during adulthood, which represent approximately 500 new cases per year and which raise particular problems: the extensive assessment which must be performed, the therapeutic solution adapted to particular situations, contraception, pregnancy, prophylaxis of endocarditis, sports or work. It is often difficult to decide to operate. Interventional catheterization represents an elegant solution in congenital heart disease in adults.