ABSTRACT
The immunosuppressive efficacy of CsA and its derivative SDZ IMM-125 was compared in highly mismatched mongrel dogs in receipt of renal allografts. At an equal dose of 15 mg/kg/day and in the same drug vehicle, SDZ IMM-125 was not superior to CsA in prolonging allograft survival. Whole blood levels of SDZ IMM-125 were lower than those achieved for CsA. No specific drug-related side effects were noticed in this model.
Subject(s)
Cyclosporine/therapeutic use , Cyclosporins/therapeutic use , Immunosuppressive Agents/therapeutic use , Kidney Transplantation , Animals , Creatinine/blood , Cyclosporine/blood , Cyclosporine/toxicity , Cyclosporins/blood , Cyclosporins/toxicity , Dogs , Female , Male , Transplantation, HomologousSubject(s)
Azepines/therapeutic use , Cyclosporine/therapeutic use , Graft Survival/drug effects , Kidney Transplantation/physiology , Platelet Activating Factor/antagonists & inhibitors , Triazoles/therapeutic use , Animals , Azepines/pharmacology , Dogs , Drug Therapy, Combination , Immunosuppression Therapy/methods , Survival Analysis , Transplantation, Homologous/physiology , Triazoles/pharmacologyABSTRACT
Five patients with deep pelvic abscesses underwent computed tomography (CT)-guided catheter drainage using a transrectal approach. The use of an outer removable plastic sheath over the catheter to facilitate positioning and prevent inadvertent damage to the mucosal wall is described. This new approach using CT guidance is discussed and the alternative routes reviewed.
Subject(s)
Abscess/surgery , Drainage/methods , Pelvis/surgery , Tomography, X-Ray Computed , Abscess/diagnostic imaging , Adult , Catheterization, Peripheral/instrumentation , Female , Humans , Male , Middle Aged , Pelvis/diagnostic imaging , RectumABSTRACT
We have examined the immunosuppressive effects of combined azathioprine (Aza) and ciclosporin (CS) in two groups of mongrel dogs receiving kidney allografts. In group 1, Aza and CS were given together daily after transplantation and in group 2 twice the dose of each drug was given separately on alternate days. Doses were halved in each group at successive 84-day intervals and all immunosuppression was stopped on day 336. Thus the same total amounts of Aza and CS were given to all recipients in both groups. Up to day-60 the incidence of rejection in each group was similar, thereafter recipients in group 1 were more susceptible to fatal infection and marrow hypoplasia. This accounted for the difference in long-term survival between the two groups (1/14 in group 1, 5/12 in group 2 at day 420). Subsequently, two long-term survivors in group 2 died, 1 on day 452 from chronic rejection and the other on day 529 from gastroenteritis with a histologically normal allograft kidney. An in vitro analysis of the alloreactive repertoire of two healthy recipients in group 2, bearing each other's kidneys for more than 2.5 years and more than 500 days without immunosuppression, showed a profound donor-specific defect which could account for their operationally tolerant state.
