Genetic factors contributing to late adverse musculoskeletal effects in childhood acute lymphoblastic leukemia survivors.

BACKGROUND: A substantial number of survivors of childhood acute lymphoblastic leukemia (ALL) suffer from treatment-related late adverse effects. While multiple studies have identified the effects of chemotherapeutics and radiation therapy on musculoskeletal outcomes, few have investigated their associations with genetic factors. METHODS: Here we analyzed musculoskeletal complications in relation to common and rare genetic variants derived through whole-exome sequencing of the PETALE cohort. Top-ranking associations were further assessed through stratified and multivariate analyses. RESULTS: DUOX2 variant was associated with skeletal muscle function deficit, as defined by peak muscle power Z score ≤ -2 SD (P = 4.5 × 10-5 for genotyping model). Upon risk stratification analysis, common variants in the APOL3, COL12A1, and LY75 genes were associated with Z score ≤ -2 SD at the cross-sectional area (CSA) at 4% radial length and lumbar bone mineral density (BMD) in high-risk patients (P ≤ 0.01). The modulation of the effect by risk group was driven by the interaction of the genotype with cumulative glucocorticoid dose. Identified variants remained significant throughout multivariate analyses incorporating non-genetic factors of the studied cohort. CONCLUSION: This exploratory study identified novel genetic variants associated with long-term musculoskeletal impairments in childhood ALL survivors. Replication in an independent cohort is needed to confirm the association found in this study.

Modulating the Photophysical Properties and Electron Transfer Rates in Diketopyrrolopyrrole-Based Coordination Polymers.

Molecular self-assembly through noncovalent interactions is a particularly efficient approach to fine-tune the optoelectronic and photophysical properties of electroactive materials. In metal-ligand coordination polymers, the final properties of the assemblies are directly related to the nature of the metal-ligand interaction. To probe for such influence on the photophysical properties of electroactive materials, a series of coordination polymers based on a well-known organic dye, diketopyrrolopyrrole, was prepared through coordination of a terpyridine-containing monomer with various metal sources, including iron, cobalt, zinc, and manganese. The resulting supramolecular polymers were characterized through multiple techniques, including UV-vis and fluorescence spectroscopy, time-correlated single-photon counting, and femtosecond transient absorption spectroscopy to reveal the impact of the metal source on the final photophysical properties of coordination polymers. As expected, important variations were found between different coordination polymers in terms of absorption, fluorescence kinetics, and electron transfer rate. While iron and cobalt-containing polymers showed ultrafast electrons transfer rates, assemblies from manganese were shown to be much less efficient, confirming the importance of metal centers. This detailed fundamental study unravels some important relationships between metal-ligand interactions, supramolecular self-assembly, and photophysical properties, ultimately leading to new avenues for the design of functional polymers based on organic dyes.

2,6-Bis(benzimidazol-2-yl)pyridine complexes of group 14 elements.

Treatment of MCl2 (M = Ge or Sn) with 2,6-bis(benzimidazol-2-yl)pyridine (G-BZIMPY, G = NBn, N(3,5-CF3)Bn, NAllyl and O) yielded the self-ionization products [G-BZIMPYMCl][MCl3] (1-6) in high yields (75-98%). Reduction reactions are examined and the nickel complexes 8 and 9 ([(NBn-BZIMPY)2Ni][MCl3]2) are isolated from the reaction of Ni(COD)2 with 1 and 2 respectively. [NBn-BZIMPYSnCl][SnCl3] shows a significantly stronger MLCT band in the UV-vis absorption spectrum than its germanium counterparts, with germanium complexes exhibiting negative solvatochromism that is not observed in tin complexes.

Recent Advances in Mechanically Robust and Stretchable Bulk Heterojunction Polymer Solar Cells.

Organic bulk heterojunction solar cells are promising candidates as future photovoltaic technologies for large-scale and low-cost energy production. It is, therefore, not surprising that research on the design and preparation of these types of organic photovoltaics has attracted a lot of attention since the last two decades, leading to constantly growing values of energy conversion and efficiency. Combined with the possibility of a large-scale production via roll-to-roll printing techniques, bulk heterojunction solar cells enable the fabrication of conformable, light-weight and flexible light-harvesting devices for point-of-use applications. This perspective review will highlight the recent advances toward mechanically robust and intrinsically stretchable bulk heterojunction solar cells. Mechanically robust fullerene-based and all-polymer devices will be presented, as well as a comprehensive overview of the recent challenges and characterization techniques recently developed to overcome some of the challenges of this research area, which is still in its infancy.

Synthesis of Heavy Dicyanamide Homologues from Air-Stable Precursors.

A convenient synthesis of dicyanophosphide and dicyanoarsenide anions is reported. These heavy homologues of the long-known and fundamentally important dicyanamide anion were formed through the nucleophilic displacement of bis(diphenylphosphino)ethane (dppe) from the pnictogen+ transfer agents [dppePn][BPh4 ] (Pn=P, As) by exposure to cyanide salts. The protocol requires three synthetic steps from commercially available materials and the [dppePn][BPh4 ] salts are remarkably temperature, air, and moisture stable. All products have been fully characterized by spectroscopic methods and by single-crystal X-ray diffraction, and the electronic structures of the DCPn anions have been assessed computationally.

Running wheel choice by Syrian hamsters.

The present study investigated the preference of male and female Syrian hamsters, Mesocricetus auratus, for different types of running wheels. Hamsters were placed individually in sets of multiple cages linked by tunnels, each cage with a different running wheel. The number of wheel revolutions in each cage was tallied daily over 40 days. The hamsters did not express a preference when offered a choice of a running surface made of metal rods spaced 9 mm apart and a similar running surface covered in plastic mesh to prevent the possible slippage of feet between the rods. The hamsters did express a clear preference for larger wheels (35 versus 23 cm diameter), and for completely circular wheels over truncated ones. They neither favoured nor rejected wheels with small obstacles along the running surface. In all experiments, preferences were more strongly expressed by males than by females. Running wheels for hamsters may be improved by enlarging their diameter (to the standards often used for rats, if practically possible) and by ensuring good footing on the running surface (a space no larger than 9 mm between evenly spaced rods seems sufficient to achieve this, at least in large wheels and for hamsters older than 55 days). Installing obstacles along the running surface does not appear to make the wheel more interesting to hamsters.

Complications associated with alloplastic implants used in orbital fracture repair.

BACKGROUND: The treatment of orbital wall fractures involves observation and/or surgical reduction with repositioning of herniated orbital tissues. To prevent reherniation of tissue and development of enophthalmos, the orbital floor or wall defect is commonly covered with an alloplastic implant. Complications associated with these implants are infrequent and generally appear as isolated case reports. METHODS: The authors reviewed the files of four consultative oculoplastic surgeons and searched for individuals with complications secondary to their alloplastic implants used during orbital fracture repair. FINDINGS: Seventeen patients were identified with a variety of complications related to their alloplastic implant. CONCLUSION: Although these implants are relatively inert and develop a fibrous capsule walling them off from the surrounding orbit, they remain foreign bodies and are thus subject to possible complications at any time. The authors review the spectrum of complications occurring with various alloplastic implants.