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1.
Am J Cancer Res ; 5(11): 3467-74, 2015.
Article in English | MEDLINE | ID: mdl-26807326

ABSTRACT

Population density implicitly involves specific distances between living individuals who exhibit biophysical forces and energies. Objective was to investigate major data bases of cancer incidence and population data to help understand the emergent properties of diseases that become apparent only when large populations and areas are considered. Correlation analyses of the annual incidence (years 2007 to 2011) of cancer in counties (2,885) of the U.S. and population densities were convergent with these quantitative predictions and suggested an inflection threshold around 50 people per square mile. The potential role of subtle or even "non-local" factors coupled to averaged population density in the viability and mortality of the human species may serve as alternative explanations to the attribution of malignancy to "chance" factors. Calculations indicated average distances between the electric force dipole of the brains or bodies of human beings generate forces known to affect DNA extension and when distributed over the Compton wavelength of the electron could produce energies sufficient to affect the binding of base nucleotides. An inclusive science of human ecology might benefit from considering subtle forces and energies associated with the individual members within the habitat that could determine the probability of cellular anomalies.

2.
Neurocase ; 18(6): 527-36, 2012.
Article in English | MEDLINE | ID: mdl-22229671

ABSTRACT

People who report objects moving in their presence, unusual sounds, glows around other people, and multiple sensed presences but do not meet the criteria for psychiatric disorders have been shown to exhibit electrical anomalies over the right temporal lobes. This article reports the striking quantitative electroencephalography, sLORETA results, and experimental elicitation of similar subjective experiences in a middle-aged woman who has been distressed by these classic phenomena that began after a head injury. She exhibited a chronic electrical anomaly over the right temporoinsular region. The rotation of a small pinwheel near her while she 'concentrated' upon it was associated with increased coherence between the left and right temporal lobes and concurrent activation of the left prefrontal region. The occurrence of the unusual phenomena and marked 'sadness' was associated with increased geomagnetic activity; she reported a similar mood when these variations were simulated experimentally. Our quantitative measurements suggest people displaying these experiences and possible anomalous energies can be viewed clinically and potentially treated.


Subject(s)
Brain Injuries/psychology , Brain Mapping , Cerebral Cortex/physiopathology , Hallucinations/psychology , Parapsychology , Brain Injuries/complications , Brain Injuries/pathology , Brain Injuries/physiopathology , Cerebral Cortex/pathology , Electroencephalography , Electromagnetic Fields , Female , Functional Laterality , Hallucinations/etiology , Hallucinations/pathology , Hallucinations/physiopathology , Humans , Middle Aged , Temporal Lobe/physiopathology , Tomography/instrumentation
3.
Int J Radiat Biol ; 86(2): 79-88, 2010 Feb.
Article in English | MEDLINE | ID: mdl-20148694

ABSTRACT

PURPOSE: To measure the effect of exposure to a specific spatial-temporal, hysiologically-patterned electromagnetic field presented using different geometric configurations on the growth of experimental tumours in mice. METHODS: C57b male mice were inoculated subcutaneously with B16-BL6 melanoma cells in two blocks of experiments separated by six months (to control for the effects of geomagnetic field). The mice were exposed to the same time-varying electromagnetic field nightly for 3 h in one of six spatial configurations or two control conditions and tumour growth assessed. RESULTS: Mice exposed to the field that was rotated through the three spatial dimensions and through all three planes every 2 sec did not grow tumours after 38 days. However, the mice in the sham-field and reference controls showed massive tumours after 38 days. Tumour growth was also affected by the intensity of the field, with mice exposed to a weak intensity field (1-5 nT) forming smaller tumours than mice exposed to sham or stronger, high intensity (2-5 microT) fields. Immunochemistry of tumours from those mice exposed to the different intensity fields suggested that alterations in leukocyte infiltration or vascularisation could contribute to the differences in tumour growth. CONCLUSIONS: Exposure to specific spatial-temporal regulated electromagnetic field configurations had potent effects on the growth of experimental tumours in mice.


Subject(s)
Magnetic Field Therapy , Melanoma, Experimental/therapy , Animals , Cell Line, Tumor , Lymphocytes, Tumor-Infiltrating/immunology , Lymphocytes, Tumor-Infiltrating/pathology , Male , Melanoma, Experimental/blood supply , Melanoma, Experimental/immunology , Melanoma, Experimental/pathology , Mice , Mice, Inbred C57BL , Microscopy, Fluorescence , Neovascularization, Pathologic
4.
Epilepsy Behav ; 15(2): 98-105, 2009 Jun.
Article in English | MEDLINE | ID: mdl-19258049

ABSTRACT

Approximately 1 year after rats were seized as young adults with lithium (3 mEq/kg) and pilocarpine (30 mg/kg) and given acepromazine or ketamine, 18 blood measures, wet tissue weights, and detailed damage scores for 107 brain structures were completed. Compared with normal and ketamine-treated rats, acepromazine-treated seized rats (total n=54) had lighter pancreata and spleens and elevated aspartate aminotransferase and alanine aminotransferase blood levels. Even though average damage did not differ, the mosaic of brain damage completely discriminated the two seized groups. Differential effects of postseizure treatment on functions of the thyroid, pancreas, and spleen were indicated. Ketamine-treated seized rats were healthier than acepromazine-treated seized rats or normal rats. This experiment demonstrates the importance of whole-organism assessment and that the single administration of a specific drug after onset of status epilepticus can produce marked differences in the evolution of brain damage and its influence on specific organs for the rest of the animal's life.


Subject(s)
Acepromazine/therapeutic use , Blood Pressure/drug effects , Dopamine Antagonists/therapeutic use , Excitatory Amino Acid Antagonists/therapeutic use , Ketamine/therapeutic use , Organ Size/drug effects , Seizures/drug therapy , Seizures/pathology , Seizures/physiopathology , Acepromazine/pharmacology , Analysis of Variance , Animals , Brain/drug effects , Brain/pathology , Disease Models, Animal , Excitatory Amino Acid Antagonists/pharmacology , Female , Ketamine/pharmacology , Lithium Chloride , Longitudinal Studies , Male , Neurologic Examination , Pilocarpine , Rats , Rats, Wistar , Seizures/chemically induced , Statistics as Topic , Thyroid Gland/drug effects , Thyroid Gland/pathology
5.
Neurosci Lett ; 450(2): 147-51, 2009 Jan 30.
Article in English | MEDLINE | ID: mdl-19022349

ABSTRACT

To test the feasibility that whole body exposure to structurally matched, physiologically patterned magnetic fields could reduce cellular injury within specific regions of the brain, young rats were seized with lithium and pilocarpine and then exposed to a sham field or to one of three computer-generated magnetic field patterns. They were digitized equivalents of the pulsed patterns of electric current known to produce long-term potential (LTP) in slices of hippocampus or entorhinal cortices. Histological analyses of their brains as adults indicated the earlier exposure to the LTP-patterned fields produced a robust reduction of damage within the primary and association areas of the right temporal cortices and the CA1/CA2 hippocampal fields. The results suggest physiologically patterned magnetic fields could be employed to target specific nuclei anywhere within the brain by matching intrinsic activity.


Subject(s)
Brain Injuries/therapy , Long-Term Potentiation/radiation effects , Magnetic Field Therapy/methods , Temporal Lobe/physiopathology , Animals , Brain Injuries/etiology , Brain Injuries/pathology , Dose-Response Relationship, Radiation , Epilepsy/chemically induced , Epilepsy/complications , Epilepsy/pathology , Lithium Chloride , Male , Pilocarpine , Rats , Rats, Wistar , Temporal Lobe/pathology
6.
Percept Mot Skills ; 97(3 Pt 2): 1307-14, 2003 Dec.
Article in English | MEDLINE | ID: mdl-15002875

ABSTRACT

The brains of adult rats, exposed prenatally to one of four intensities (between 10 nanoTesla and 1.2 microTesla) of either a frequency-modulated magnetic field or a complex sequenced field designed to affect brain development, were examined histologically. Although from each intensity some rats that had been exposed to the complex sequenced magnetic field showed minor anomalies, those exposed to intensities between 30 nT and 180 nT exhibited conspicuous anomalous organizations of cells within the hippocampal formation. In other studies, rats that had been exposed during their entire prenatal development to the complex sequenced field displayed significantly more activity in the open field and poorer spatial memory during maze learning. Photomicrographs are shown of one conspicuous morphological anomaly within the right hippocampus of an adult rat exposed prenatally to the complex sequenced magnetic field with intensities between .3 mG and .5 mG (30 nT to 50 nT). The results suggest that complex magnetic fields, whose temporal structures approach the time constants of normal biochemical processes, can permanently alter the development of the brain.


Subject(s)
Hippocampus/abnormalities , Hippocampus/embryology , Magnetics/adverse effects , Animals , Female , Neuroglia/pathology , Pregnancy , Rats
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