ABSTRACT
A computer simulation has been used to calculate the effects of J coupling on the amplitudes of echoes produced by CPMG sequences. The program computes the evolution of the density matrix for different pulse intervals and can predict the signals obtainable from spin systems of any size and complexity. Results from the simulation confirm the prediction that a decrease in the effects of J coupling is largely responsible for the bright fat signal seen in fast spin echo imaging at high pulse rates. The effects of J coupling on CPMG echotrains are examined for A3B2 and A3B2C2 spin systems over a wide range of J coupling and chemical shift values and pulse spacings. The effects of J coupling on the point spread function obtained with fast spin echo imaging are also discussed.
Subject(s)
Computer Simulation , Magnetic Resonance Spectroscopy , Models, Chemical , Algorithms , Alkenes/chemistry , Artifacts , Electron Spin Resonance Spectroscopy , Forecasting , Humans , Image Processing, Computer-Assisted/methods , Magnetic Resonance Spectroscopy/methodsABSTRACT
The DIET (or dual interval echo train) sequence, a modification of the fast spin echo (FSE) sequence that selectively reduces signal from fat in MR images, has been investigated. The DIET sequence uses an initial echo spacing longer than that of a conventional FSE sequence, thus allowing J coupling-induced dephasing to take effect. The sequence is evaluated theoretically, and its effectiveness on a hydrocarbon (1-pentene) is demonstrated numerically using density matrix calculations. The sequence is also evaluated experimentally using in vitro solutions and in vivo imaging. The efficacy of the sequence is compared for different lipid chemical structures, field strengths, and pulse sequence parameters.
Subject(s)
Adipose Tissue/anatomy & histology , Echo-Planar Imaging/methods , Signal Processing, Computer-Assisted , Algorithms , Humans , Hydrocarbons/analysis , Lipids/analysis , Magnetic Resonance Spectroscopy , Mathematics , Numerical Analysis, Computer-Assisted , Phantoms, ImagingABSTRACT
The ability of the asymmetric spin-echo (ASE) pulse sequence to provide different degrees of spin-echo (SE)-type and gradient-echo (GE)-type contrast when imaging media containing magnetic inhomogeneities is investigated. The dependence of the ASE signal on the size of magnetic field perturbers is examined using theory, computer simulations, and experiment. A theoretical prediction of the ASE signal is obtained using the Anderson-Weiss mean field theory, the results of which are qualitatively supported by computer simulations and experimental studies. It is shown that the ASE sequence can be used to tune the range of perturber sizes that provide the largest contributions to susceptibility contrast effects.
