[Hexamidine content of the blood plasma and cerebrospinal fluid in patients with epilepsy]. / O soderzhanii geksamidina v plazme krovi i likvore u bol'nykh épilepsiei.

In 74 patients with different attack rates and patterns mean levels of hexamidine in the blood plasma and cerebrospinal fluid were 15.9 micrograms/ml and 7.86 micrograms/ml, respectively, the former almost twice as high as the latter. Both were found to correlate with the drug daily doses and other anticonvulsants administration.

[Concentration of benzonal in the blood of epileptic patients at different daily doses and with other anticonvulsants]. / Kontsentratsiia benzonala v krovi bol'nykh épilepsiei pri raznykh sutochnykh dozakh i prieme drugikh antikonvul'santov.

A study involving 36 epileptic patients and 8 control subjects was devoted to the optimization of antiepileptic drug therapy with the help of determining the blood levels of anticonvulsants (benzonal, phenobarbital). The daily dose of an anticonvulsant directly correlated with its blood levels. Blood levels of benzonal increased upon the additional administration to patients of hexamidine or hexamidine and diphenylhydantoin mixtures. A reduction in the daily dose of benzonal by 2/3 was attended by a 50% decline in its blood levels.

[Blood testosterone levels in nonpsychotic psychopath-like behavior disorders among adolescents with accelerated or delayed physical development]. / O soderzhanii testosterona v krovi pri nepsikhoticheskikh psikhopatopodobnykh narusheniiakh povedeniia u podrostkov s akseleratsiei i retardatsiei fizicheskogo razvitiia.

The authors examined 128 male adolescents admitted to a psychiatric hospital for the psychopathlike syndrome free of psychotic manifestations which was associated with the abnormal rate of sexual development. A correlation was established between the maturation rate, plasma testosterone levels and clinical features of behavioural abnormalities. Retarded puberty was related to decreased testosterone concentrations throughout the pubertal period. In cases of accelerated development the testosterone content was increased at the age of 14-15 years, i.e. in the period of the most intensive maturation; later on, in the process of reaching puberty, the hormone level approaches the age specific rate. The clinical picture of behavioural disorders in the presence of retarded or accelerated development depends on whether the symptoms caused by abnormal rates of maturation were combined with the symptoms of cerebral insufficiency. Adolescents with accelerated development unattended by cerebral insufficiency manifestations were characterized by marked aggression and an increase in desires. Depending on the degree of activity, asthenic nature, leadership capacities and the level of intellect, they are divided into two clinical variants: epileptoid and conformational-epileptoid types of accentuations. Cerebral insufficiency was reflected in the form of lowered intellect, explosiveness and impaired desires in the clinical picture of both accelerated and retarded pubertal development.

[Effect of chemical destruction of hypothalamic monoaminergic terminals on function of the adrenal cortex, thyroid gland and enterochromaffin system]. / Vliianie khimicheskogo razrusheniia monoaminergicheskikh terminalei gipotalamusa na funktsiiu kory nadpochechnikov, shchitovidnoi zhelezy i énterokhromaffinnoi sistemy.

In experiments on rats the influence of noradrenergic, dopaminergic terminal destruction after 6-hydroxydopamine intraventricular injection and of serotoninergic terminal damage following 5,6-hydroxytryptamine administration on the adrenal cortex, thyroid and enterochromaffin body function was studied under basal conditions and during cold stress. As a result of noradrenergic terminal destruction basal- and cold stress-induced functional activity of the adrenal cortex and enterochromaffin body augmented. After serotoninergic terminal damage stress-induced intensification of the functional activity of the endocrine glands mentioned was blocked. The thyroid gland function changed under the hypothalamic noradrenergic and serotoninergic terminal destruction. In the first case a cold-induced rise in the gland functional activity was blocked and in the second one a stress-provoked growth of the thyroid gland activity was rather more than in the control.

[Role of hypothalamic monoaminergic structures in regulating sympatho-adrenal system function]. / Rol' monoaminergicheskikh struktur gipotalamusa v reguliatsii funktsii simpatiko-adrenalovoi sistemy.

The effect of pharmacological destruction of hypothalamic monoaminergic terminals on the basal and cold stress-induced secretion of neurohormones of the sympathoadrenal system (SAS) in rats was studied. The data obtained on biochemical and histochemical analysis of the hypothalamus (dopamine, noradrenaline and serotonin level, the picture of catecholaminergic terminal fluorescence) were compared with adrenaline and noradrenaline content in blood. It is assumed that function of the SAS is inhibited by hypothalamic noradrenaline and stimulated by dopamine and serotonin under cold stress.

[Effect of destruction of the median eminence on thermoregulation]. / Vliianie razrusheniia medial'noi éminentsii na termoreguliatsiiu

In male rats of 180-240 g weight, alterations of general thermoregulation and of functional activity of the suprarenal cortex, thyroid gland, and enterochromaffine system were studied after electrolytic lesion of the hypothalamic mesial eminence. In thermoneutral conditions, functions of the suprarenal cortex and thyroid gland remained unchanged while activity of the enterochromaffine system was reduced. Cooling decreased abruptly the reaction of thermoregulation and the functional activity of the endocrine glands. The data suggest the neurosecretory granules of the hypothalamic mesial eminence to participate in regulation of the organism temperature homeostasis in rats.