ABSTRACT
Clinical criteria for the diagnosis of Alzheimer's disease include insidious onset and progressive impairment of memory and other cognitive functions. There are no motor, sensory, or coordination deficits early in the disease. The diagnosis cannot be determined by laboratory tests. These tests are important primarily in identifying other possible causes of dementia that must be excluded before the diagnosis of Alzheimer's disease may be made with confidence. Neuropsychological tests provide confirmatory evidence of the diagnosis of dementia and help to assess the course and response to therapy. The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information become available.
Subject(s)
Alzheimer Disease/diagnosis , Alzheimer Disease/diagnostic imaging , Alzheimer Disease/psychology , Humans , Psychological Tests , Tomography, Emission-Computed , Tomography, X-Ray Computed , United States , United States Dept. of Health and Human ServicesSubject(s)
Cell Aggregation , Multiple Sclerosis/immunology , Antigens , Cell Membrane/immunology , Cell Membrane/physiology , Erythrocytes/physiology , Humans , Lipoproteins/physiology , Lymphocytes/physiology , Monocytes/physiology , Multiple Sclerosis/diagnosis , Multiple Sclerosis/metabolism , Multiple Sclerosis/physiopathology , Myelin Basic Protein/physiology , T-Lymphocytes/immunology , T-Lymphocytes/physiologyABSTRACT
Experimental cerebral aneurysms were induced in rats in which the left carotid artery was ligated. The rats were rendered hypertensive by the Goldblatt procedure, and fed a diet containing beta-aminopropionitrile. These intracranial aneurysms have significant gross and microscopic similarities to human berry aneurysms. The procedures and microscopic observations indicate that this experimental model could be useful for studying the development, pathophysiology, and therapy of saccular aneurysms.