Subject(s)
Cartilage/pathology , Hamartoma/pathology , Nose Diseases/pathology , Child , Chondrosarcoma/pathology , Diagnosis, Differential , Epistaxis/etiology , Hamartoma/complications , Hamartoma/metabolism , Humans , Immunohistochemistry , Male , Nasal Obstruction/etiology , Nose Diseases/complications , Nose Diseases/metabolism , Rhabdomyosarcoma/pathologyABSTRACT
Malignant histiocytosis is a rare invasive proliferation of neoplastic histiocytes. Cases previously reported as malignant histiocytosis were shown to be lymphomas of T or B lineage, especially anaplastic large-cell lymphomas. A case of malignant histiocytosis is described, in which a patient presenting with symptoms suggestive of pneumonia suddenly deteriorated and died. At autopsy, a large quantity of fresh blood, originating from several ruptured nodules on the enlarged spleen, was seen in the peritoneal cavity. Extensive infiltration by pleomorphic tumour cells and erythrophagocytosis by tumour cells were seen on histological examination of the spleen. Immunohistochemical analysis and staining were carried out. This is the second reported case of malignant histiocytosis presenting with spontaneous splenic rupture.
Subject(s)
Histiocytic Sarcoma/complications , Splenic Rupture/etiology , Fatal Outcome , Female , Histiocytic Sarcoma/pathology , Humans , Liver/pathology , Middle Aged , Neoplasm Invasiveness , Rupture, Spontaneous/etiology , Spleen/pathologyABSTRACT
We report a rare case of granulocytic sarcoma of the breast presenting as an isolated breast lump antedating bone marrow manifestation of acute myelogenous leukaemia.
Subject(s)
Breast Neoplasms/diagnosis , Leukemia, Myeloid, Acute/complications , Sarcoma, Myeloid/diagnosis , Aged , Breast Neoplasms/complications , Breast Neoplasms/diagnostic imaging , Breast Neoplasms/pathology , Diagnosis, Differential , Female , Humans , Radiography , Sarcoma, Myeloid/complications , Sarcoma, Myeloid/diagnostic imaging , Sarcoma, Myeloid/pathologyABSTRACT
Malathion shows promise as a substitute for chlorinated-hydrocarbon insecticides in the control of malaria whenever the latter are unsuitable because of Anopheles resistance or other reasons. A field trial of malathion was carried out in 1963-64, covering an area of about 500 km(2) with a population of about 26 000, in Masaka District, southern Uganda. All houses and animal shelters were sprayed with malathion at 2 g/m(2) at roughly 4-month intervals. The average combined densities of the females of the two main malaria vectors, Anopheles funestus and An. gambiae, fell from an average of 66 per shelter per day in a pre-trial survey in 1960-61 to 0.0011 at the end of 1964 in the sprayed area; no significant changes were noted in unsprayed comparison areas. The transmission of the infection in humans was apparently interrupted when allowance was made for imported cases.The presence of unsprayed surfaces in houses which had recently been built or altered interfered somewhat with complete coverage. Case detection was reliable and achieved excellent coverage.No toxic effects of malathion in humans were noted, while the effect on mosquitos was considerable even in the absence of direct contact. This effect of malathion lasted for a considerably shorter period of time in houses roofed with corrugated iron than with thatch; this should be borne in mind in the design of spraying programmes.
