Conservative bladder management in advanced multiple sclerosis.

Anticholinergics and intermittent catheterization are the cornerstones of bladder management in early multiple sclerosis (MS). In advanced MS however, bladder management is based more on tradition than on evidence. Nurses seem to deal with catheter problems and chronic incontinence. Despite the abundant use of indwelling catheters, there is a lack for guidelines on catheter-induced problems. The psychosexual and social impact of bladder problems in advanced MS is often neglected. The international multidisciplinary special interest group on sexual, urological and bowel dysfunction in MS (SUBDIMS) as a special interest group of the Rehabilitation in Multiple Sclerosis (RIMS) was confronted with a high variability in practice and a lack of guidelines. A literature review was prepared during three multidisciplinary expert meetings. This review will be the basis of further initiatives to improve the urological treatment of patients with advanced MS.

[C0Q10 in the prevention and treatment of primary osteoporosis. Preliminary data]. / Il C0Q10 nella prevenzione e nella terapia dell'osteoporosi primitiva. Dati preliminari.

Preliminary data are reported of an as yet uncompleted clinical study aimed at evaluating the therapeutic efficacy of C0Q10 for primary osteoporosis. In spite of the small number of subjects treated (only 5) the results obtained are evidence of the efficacy of this agent which had never before been used in the therapy of osteoporosis. The possible mechanisms of action C0Q10 are discussed in the light of an original interpretation of the etiopathogenesis of this very complex bone disease. Details of the study will be reported once the trial has been completed.

[Early clinical diagnosis of osteoporosis using auscultatory percussion. Therapeutic monitoring]. / Diagnosi clinica precoce dell'osteoporosi con la percussione ascoltata. Monitoraggio terapeutico.

The authors describe the auscultatory percussion method, easy to perform and reliable in early bed-side diagnosis of osteoporosis, even if asymptomatic. In addition, the great importance of early diagnosis in preventing fractures complicating osteoporosis is underlined. The results obtained with prompt administration of current therapy in 25 cases, diagnosed with the aid of auscultatory percussion, are reported. Finally, practical use of this method for both therapeutic monitoring and individual prescription of drugs, is emphasized.

[Coffin-Lowry syndrome. Description of 2 cases associated with cardiovascular anomalies]. / La sindrome di Coffin-Lowry. Descrizioni di due casi con associazione di anomalie cardiovascolari.

In this work the authors describe two cases of Coffin-Lowry syndrome, diagnosed in two brothers of different age and with a different degree of evolution of the illness. The brothers present the mitral prolapse association. The clinic and instrumental examination have been executed. The various pathogenetic hypothesis have been discussed and the authors propose the most recent that considers the fibroblast incapable to produce the substances of connective matrix. This hypothesis explain also the evolution and the progression of the lesion at the interested organs (skin, joints, bones, heart). The illness is genetic, with a X-linked, semidominant transmission.

[Holotelencephaly: description of a case]. / Olotelencefalia: descrizione di un caso.

This study describe a case of SNC malformation that belongs to the prosencephalization defects. Particularly, the degree of cerebral anomalies and the gravity of facial abnormalities place the case in the group of Holotelencephalies. We have considered the ethiopathogenetic connections that can cause such embryonic damage, the clinical characteristics, the evolution and the prognosis, by the light of the dates provided by literature. Our patient is a six month-old female put under observation since her birth.