1.
Antimicrob Agents Chemother
; 61(7)2017 07.
Article
in English
| MEDLINE
| ID: mdl-28607019
ABSTRACT
Recent findings have identified Klebsiella pneumoniae strains that are pan-ß-lactam susceptible (PBL-S) but piperacillin-tazobactam resistant (TZP-R) in vitro We assessed the efficacy of a humanized exposure of piperacillin-tazobactam (TZP) against 12 TZP-R/PBL-S K. pneumoniae isolates in an immunocompromised murine lung infection model. Discordance between the in vitro resistance profile and the in vivo efficacy of human-simulated TZP exposures against this phenotypic profile was observed. Additional studies are required to define the clinical implications of these TZP-R/PBL-S strains.
Subject(s)
Anti-Bacterial Agents/pharmacology , Penicillanic Acid/analogs & derivatives , Humans , Klebsiella pneumoniae/drug effects , Klebsiella pneumoniae/genetics , Microbial Sensitivity Tests , Penicillanic Acid/pharmacology , Piperacillin/pharmacology , Piperacillin, Tazobactam Drug Combination , beta-Lactamases/genetics , beta-Lactamases/metabolism
2.
Clin Microbiol Infect
; 23(8): 581-582, 2017 Aug.
Article
in English
| MEDLINE
| ID: mdl-28254605