1.
Bioorg Med Chem Lett
; 13(19): 3243-6, 2003 Oct 06.
Article
in English
| MEDLINE
| ID: mdl-12951101
ABSTRACT
A series of novel MMP-13 and TNF-alpha converting enzyme inhibitors based on piperazine 2-hydroxamic acid scaffolds are described. The TACE, MMP-1 and MMP-13 activity of these inhibitors as well as the effect of substitution of the piperazine nitrogen and the P-1' benzyloxy tailpiece is discussed. Moderate in vivo activity is observed with several members of this group.
