[Tissue factor and it's inhibitor in patients up to 50 years of age with ischemic stroke]. / Czynnik tkankowy i jego inhibitor u chorych do 50 roku zycia z niedokrwiennym udarem mózgu.

Stroke is the third leading cause of death and an important cause of longterm disability. Up to 10% of stroke patients is younger than 45 years old. In the present study we measured and compared TF and TFPI concentrations in 50 ischemic stroke patients up to the age of fifty and in 30 control subjects matched for age. TF concentration was significantly higher in ischemic stroke patients, TFPI concentration did not differ compared to controls. No relationship was established between TF and TFPI in relation to clinical subtypes of stroke, sex, smoking, plasma cholesterol level, hypertension, previous stroke.

[Effect of total cholesterol level on platelet aggregation in patients with migraine]. / Wplyw stezenia cholesterolu calkowitego na agregacje plytek krwi u chorych na migrene.

In 34 women with simple migraine the total cholesterol concentration in the serum and the platelet aggregation index according to Wu and Hoak were determined. The blood cholesterol levels differed in them. Two groups of patients were isolated: group I with cholesterol level above the upper normal range and group II with cholesterol within this range. The mean concentration of this lipid differed significantly between these groups (p less than 0.001). The platelet aggregation index in group I was significantly lower than in the group with normal cholesterol level (p less than 0.05). During migraine attack a further fall was observed in the platelet aggregation index in the group with high cholesterol level (p less than 0.01). The authors suppose that cholesterol concentration may be one of the factors determining differences in platelet behaviour in migraine patients.

[Platelet aggregation in patients with migraine during the pain attack and in the pain-free period]. / Agregacja pllytek krwi u chorych na migrene w czasie napadu bólu i w okresie bezbólowym.

In 31 women with a history of migraine platelet aggregation was studied between migrainous attacks, and in 14 of them during an attack of migraine. The method of Born and Cross was used. The rates of the first and second phases of aggregation were calculated and the quantitative index of aggregation curve according to Cavallero was calculated. Adrenaline in concentrations of 2 and 4 micron M was used as the aggregating factor. No differences were found in the mean rates of the first phase of aggregation between the patients and the controls. The rate of the second phase in the time between migraine attacks was significantly higher in patients with migraine (p less than 0.001) than in healthy subjects. During migraine attack the mean rate of the second phase decreased significantly (p less than 0.02 and p less than 0.001). These changes of the rate of the second phase may be explained as due to disturbances in the release of the aggregating substances from platelets and accumulation of platelet-activating substances.