Subject(s)
Doxycycline/adverse effects , Intestinal Diseases/diagnosis , Intestinal Mucosa/drug effects , Ulcer/diagnosis , Adult , Biopsy , Female , Gastroscopy , Humans , Intestinal Diseases/chemically induced , Intestinal Diseases/pathology , Intestinal Mucosa/diagnostic imaging , Intestinal Mucosa/pathology , Ulcer/chemically induced , Ulcer/pathologyABSTRACT
Inflammatory pseudotumour is a rare form of a liver mass. We report the case of a 28-year-old man presenting with obstructive jaundice, in whom an inflammatory pseudotumour arose with the resolution of a mucus secreting cystic liver lesion. The initial features suggested an intrahepatic cystadenoma or cystadenocarcinoma, which on its involution left a solid mass. Histopathology showed an inflammatory pseudotumour with no evidence of malignancy. A similar case has been reported recently, with the development of an inflammatory pseudotumour following collapse of a liver cyst seen on imaging. These two cases may shed some light on the origins of these rare liver lesions.
Subject(s)
Biliary Tract Neoplasms/pathology , Cystadenoma/pathology , Granuloma, Plasma Cell/etiology , Liver Diseases/etiology , Adult , Biliary Tract Neoplasms/diagnostic imaging , Cholangiopancreatography, Endoscopic Retrograde , Cystadenoma/diagnostic imaging , Granuloma, Plasma Cell/diagnostic imaging , Granuloma, Plasma Cell/pathology , Humans , Liver Diseases/diagnostic imaging , Liver Diseases/pathology , Magnetic Resonance Imaging , Male , Neoplasm, Residual , Tomography, X-Ray ComputedABSTRACT
PURPOSE: Goblet cell appendiceal carcinoids represent rare tumors that exhibit histologic features of both adenocarcinomas and neuroendocrine tumors. We present the long-term results of a series of 15 patients, focusing on clinical manifestations, diagnosis, and management. METHODS: Eight male and seven female patients (median age, 52.8 years) were included. Final diagnosis was confirmed by histology. Patients were evaluated clinically, biochemically, and radiologically every four months. Median follow-up was 30 months. RESULTS: The majority of patients (7/15) presented with symptoms compatible with acute appendicitis. Right hemicolectomy was performed in all except one, who subsequently developed metastases. Three patients had metastases at previous diagnosis. Plasma chromogranin-A was slightly elevated in two of them, while urinary 5-hydroxy-indol-acetic acid was normal. (111)Indium-labeled octreotide scintigraphy was positive only in two of the four patients with metastases. Ki67 index was greater than 20 percent in all of them, while in only one with local tumor. Combination chemotherapy with either cisplatin plus etoposide or with 5-fluorouracil, cisplatin, and streptozotocin was administered to all patients with metastases resulting in temporary stabilization of disease. Twelve patients are alive, while three died of their disease 9, 13, and 14 months after diagnosis. CONCLUSIONS: The diagnostic value of chromogranin-A, urinary 5-hydroxy-indol-acetic acid, and (111)Indium-labeled octreotide scintigraphy seems to be limited in these tumors. Ki67 index appears to predict tumor behavior. Right hemicolectomy may reduce the risk of developing metastases. Chemotherapy may have efficacy in metastatic disease, however, more data are required to determine this and the optimal regimen.
Subject(s)
Appendiceal Neoplasms/diagnosis , Carcinoid Tumor/diagnosis , Adult , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Appendectomy , Appendiceal Neoplasms/drug therapy , Appendiceal Neoplasms/pathology , Appendiceal Neoplasms/surgery , Biomarkers, Tumor/analysis , Carcinoid Tumor/drug therapy , Carcinoid Tumor/pathology , Carcinoid Tumor/surgery , Cisplatin/administration & dosage , Colectomy , Combined Modality Therapy , Diagnosis, Differential , Etoposide/administration & dosage , Female , Fluorouracil/administration & dosage , Humans , Immunohistochemistry , Ki-67 Antigen/analysis , Male , Middle Aged , Neoplasm Metastasis , Retrospective Studies , Streptozocin/administration & dosageABSTRACT
Grading of the severity of chronic hepatitis and staging of its structural consequences are widely used in clinical trials of therapy and in research. Simple and complex methods are available. Intra- and interobserver variation can be reduced but not eliminated, because grading and staging are essentially subjective. The data are categorical rather than numerical and must be treated accordingly. Morphometry of fibrous tissue offers a different approach to biopsy assessment.
