ABSTRACT
The administration of testosterone and metandrostenolone to male rats in doses of 10 and 20 mg/kg for 10 days produced a decrease of the thymus mass and a reduction of the thymic serum factor content. A phytoecdisteroid ecdisterone not possessing the androgenic activity fails to influence the thymus mass and the content of the thymic serum factor.
Subject(s)
Anabolic Agents/pharmacology , Thymus Gland/drug effects , Animals , Dose-Response Relationship, Drug , Ecdysterone/pharmacology , Male , Methandrostenolone/pharmacology , Mice , Mice, Inbred C57BL , Organ Size/drug effects , Rats , Testosterone/pharmacology , Thymic Factor, Circulating/analysis , Thymic Factor, Circulating/drug effects , Time FactorsABSTRACT
Proteinuria, hematuria and leukocyturia in chronic alcoholics were mostly pronounced in abstinence, particularly in those with a long-term alcoholism. In proportion to alcohol d s-intoxication treatment, their urinalyses normalized. Being hospitalized in a sober state the patients had insignificantly elevated or practically normal urinalyses. Disulfiramum tests performed both in abstinence or sobriety demonstrated pronounced abnormalities in urinalyses. In the course of disulfuramum treatment in the absence of alcohol tests urinalyses normalized completely. Urinalysis follow-up demonstrated the appearance of renal failure due to hemodynamic disorders that ran the pattern of renal sensitization due to the effect of acetaldehyde production in alcohol tests.
Subject(s)
Alcoholism/urine , Disulfiram/therapeutic use , Proteinuria/urine , Alcoholism/drug therapy , Combined Modality Therapy , Ethanol/adverse effects , Humans , Substance Withdrawal Syndrome/drug therapy , Substance Withdrawal Syndrome/urine , Time Factors , Urine/cytologyABSTRACT
Limbeck and Ribier's method currently used for the measurements of red cell osmotic resistance is not devoid of shortcomings: it is labor-consuming and visual assessment of hemolysis is inaccurate. Deitche's photometric method or its variant described in this paper are more fit for the determination of red cell osmotic resistance.