[Anti-arrhythmic action of N-(aminoalkylene) derivatives of indoline-2,3-diones and 1,2-benzene-dicarboxiamides]. / Indolin-2,3-dionu ir 1,2-benzendikarboksimidu N-aminoalkilintu dariniu sinteze ir antiaritminis poveikis.

The aim of study was to modify the structure of indoline-2,3-diones and 1,2-benzenedicarboximides using the pharmacophores of new generation antiarrhythmics and to assess the impact of their structure upon the acute toxicity and antiarrhythmic action. The quaternary derivatives of N-aminoalkylindoline-2,3-diones and N-aminoalkyl-1,2-benzenedicarboximides were synthesized. The acute toxicity of compounds for white mice was tested. Using the calcium chloride- and aconitine-induced arrhythmia models in rats the antiarrhythmic action of derivatives was assessed. It was shown, that the antiarrhythmic action of N-aminoalkyl-1,2-benzenedicarboximides increases by lengthening of alkylene chain from one methylene group to two or by the presence of methanesulfonamide group in benzene ring. These structural changes, especially the presence of methanesulfonamido group, cause the decrease of acute toxicity. Among the N-aminoalkylindoline-2,3-diones the most antiarrhythmic action and minimal toxicity demonstrates the compound containing the bromo-substituted benzene ring.