[Ischemic heart disease--clinical, biochemical and immunobiological parallels]. / Iskhemichna bolest na surtseto--klinichni, biokhimichni i imunobiologichni paraleli.

In patients with various forms of ischemic heart disease the following indices were examined by radial immunodiffusion: alpha-1-acid glycoprotein, alpha-1-antitrypsin, haptoglobin, alpha-2-glycoprotein, beta-2-glycoprotein, immunoglobulin, C3 and C4 complement fractions. The changes in the serum glycoproteins during the acute phase of myocardial infarction are pointed out. The changes in the immunoglobulins and the complement fractions in patients with ischemic heart disease are discussed. Their determination in patients with stenocardia and past myocardial infarction is of no diagnostic value.

[Antiactin antibodies in patients with acute myocardial infarct and the intermediate syndrome]. / Antiaktinovi antitela pri bolni s ostur infarkt na miokarda i intermedieren sindrom.

The anti-actinic antibodies were determined via counter electrophoresis on cellulose-acetate in 35 clinically healthy subjects and 57 patients with various forms of IHD. Antibodies were established in only three out of the healthy subjects and with low titres (1:2). Positive anti-actinic antibodies were established 82.8% of the patients with IHD. Their origin and importance for the pathogenesis of the disease are discussed.

[Ambulatory treatment of paroxysmal supraventricular arrhythmias with verapamil (isoptin)]. / Ambulatorno lechenie na pristupnite nadkamerni dizritmii s verapamil (izoptin).

Twenty patients, seven of them with paroxysmal supraventricular tachycardia; 8 with paroxysmal auricular flutter; 3 with paroxysmal auricular fibrillation and 2 with paroxysmal atrial tachycardia, with stage II of A-V block, were treated intravenously with isoptin, with an average dose of 0.1 mg/kg body mass. Ten, out of them, restored their sinus rhythm, 7 considerably slowed down the heart rate and 3 failed to respond. Adverse effects were observed only in one patient--transitory hypotension.

[Effect of the use of lidocaine on patients with acute myocardial infarct]. / Efekt ot prilozhenieto na lidokain pri bolni s ostur miokarden infarkt.

In 411 patients with acute myocardial infarction (AMI) the effect of intravenous lidocaineeee administration was studied in a suboptimal dose - under 1,5 mg/min (to 1979) and in the optimal dose - over 1,5 mg/min, minimum 2 mg/min during the first 12 hours, with an average 24 h dose, 3,0 g in the course of 48 hours. The patients were grouped into three prognostic groups, depending on their initial assessment according to the coronaryprognostic index of M. R. Norris (1969). The indices, via which the drug effect was determined; were 13, the more significant ones beind: ventricular arrhythmias, early lethality rate, postinfarction angina pectoris and regression fo lesion-ischemic ST-T alterations. It was established, after the analysis of the data obtained, that the prophylactic and therapeutic use of lidocain, considerably reduced the incidence of ventricular arrhythmias in patients with AMI. Lidocain, in an optimal dose, reduces the incidence, justifying its routine administration. Lidocain effect on ventricular arrhythmias, the early lethality rate and certain complications (postinfarction angina pectoris, early cardiac insufficiency, regression of ST-T alterations) in AMI, depend on the initial prognosis and the stage of the hemodynamic disorders.

[Serotonin in arterial hypertension]. / Serotonin pri bolni s arterialna khipertoniia.

Serotonine was determined in 67 patients, 39 with arterial hypertension and 28--with normal arterial pressure. The patients are grouped into three: first group--males and females with confirmed atherosclerosis without and with systolic hypertension; the second group covers males with atherosclerosis without and with systolic hypertension and the third group --males and females with hypertonic diseases, II stage, the basic disease being complicated by atherosclerosis. The highest serotonine values were found in the patient groups without and with systolic hypertension, hypertonic disease with systolic-diastolic hypertension in males with diagnosed atherosclerosis. Serotonine impressed to be relatively lower in the females with hypertonic disease and atherosclerosis. Some humoral factors in females are presumed to be probable causes for those differences but further studies are still necessary.

[Alpha cholesterol in ischemic heart disease and myocardial infarct]. / Nivata na alfa-kholesterola pri iskhemichna bolest na surtseto s miokarden infarkt.

Alpha-cholesterol is one of the risk factors for the manifestation of myocardial infarction. The authors examined 48 patients with ischemic heart disease, complicated with myocardial infarction, 28 males and 20 females, aged from 40 to 60, treated at the Clinic of Cardiovascular Diseases with Intensive Unit, RIID--Med. Academy. Ninety three control subjects were examined for a comparison--43 males and 50 females, aged from 40 to 60. Lower alpha-cholesterol values were found in the patients with myocardial infarction. Those data coincide with the communications in literature. Alpha-cholesterol reduction could be assessed as an indirect risk factor of a atherosclerosis, ischemic heart disease resp.

[Clinical trial of the Bulgarian digitalis preparation, Digilanide C used intravenously]. / Klinichno izpitvane na bulgarskiia digitalisov preparat Digilanid C za venozno prilozhenie

The Bulgarian digitalis preparation Digilanid C for venous application has a satisc factory effect on the majority of the patients (67 per cent) with light and moderate chronic cardia insufficiency and espically in case of tachycardia in auricular fibrillation. The comparison of the results between the group of 46 patients, treated with Digilanid C and the control group of 20 patients treated with Isolanid (Richter) do not reveal essential differences in the major part of the results obtained.