Dipolar order in an amphidynamic crystalline metal-organic framework through reorienting linkers.

Amphidynamic crystals, which possess crystallinity and support dynamic behaviours, are very well suited to the exploration of emergent phenomena that result from the coupling on the dynamic moieties. Here, dipolar rotors have been embedded in a crystalline metal-organic framework. The material consists of Zn(II) nodes and two types of ditopic bicyclo[2.2.2]octane-based linkers-one that coordinates to the Zn clusters through two 1,4-aza moieties, and a difluoro-functionalized derivative (the dipolar rotor) that coordinates through linked 1,4-dicarboxylate groups instead. Upon cooling, these linkers collectively order as a result of correlated dipole-dipole interactions. Variable-temperature, frequency-dependent dielectric measurements revealed a transition temperature Tc = 100 K, when a rapidly rotating, dipole-disordered, paraelectric phase transformed into an ordered, antiferroelectric one in which the dipole moments of the rotating linkers largely cancelled each other. Monte Carlo simulations on a two-dimensional rotary lattice showed a ground state with an Ising symmetry and the effects of dipole-lattice and dipole-dipole interactions.

Associations of behavior-based measurements and clinical disease in preweaned, group-housed dairy calves.

Producers report bovine respiratory disease and neonatal calf diarrhea as the 2 most common diseases in preweaned calves, both of which can affect calf performance and welfare. Housing calves in groups during the preweaning period has increased in popularity and has the potential to improve calf welfare, but only if producers can detect and treat disease efficiently. A health-screening tool is needed that allows producers to identify suspect animals but minimize the time spent examining healthy animals. The objective of this study was to determine if disease in preweaned, group-housed dairy calves was associated with behavioral measures of illness. This cross-sectional study included the evaluation of preweaned, group-housed calves (n=206) on 4 farms in Wisconsin, United States. Farm visits included the scoring of key behaviors (abnormal posture when lying or standing, isolation from the group, lethargy, and 2 approach tests that tested the willingness of calves to approach a stationary person) that were hypothesized to be components of sickness behavior. Following the behavior scoring, calves underwent an individual health assessment for bovine respiratory disease, neonatal calf diarrhea, and umbilical infections. Each behavior category was scored as normal (0 points) or abnormal (1 point), and then categories were summed to obtain a total behavior score for each calf. Behavior scores ranged from 0 (normal) to 5 (severely abnormal). A total behavior score of 3 or greater was considered positive for disease. The outcome of a positive or negative test on the behavior score were analyzed using PROC LOGISTIC (SAS Institute Inc., Cary, NC) and the model controlled for calf age and farm. Bovine respiratory disease was significantly associated with a behavior score of 3 or greater. The use of a behavior score shows promise as a screening tool for disease in preweaned calves.

Associations between health status and the probability of approaching a novel object or stationary human in preweaned group-housed dairy calves.

Neonatal calf diarrhea (NCD) and bovine respiratory disease (BRD) are the 2 most prevalent diseases affecting the welfare and productivity of preweaned dairy calves in the United States. Early detection of these diseases improves both the probability of recovery and animal welfare. Group housing of preweaned calves is increasing in popularity and disease detection in a socially competitive environment can be challenging. One method of detecting disease is through the observation of key behaviors that occur during illness. Novel object and stationary human approach tests can be used to measure exploratory behavior, which is decreased during the expression of sickness behavior. The objectives of this study were (1) to determine associations between 4 categories of health status and the probability of calves approaching a novel object or stationary human, and (2) to determine the associations between rectal temperature and the probability of calves approaching. Holstein heifer calves (n = 75) in group housing were tested weekly for the first 6 wk of life for their willingness to approach a novel object (OBJ) or stationary human (SH). After the approach tests, calves were evaluated by research staff using a standardized health-scoring system. Treatment records were obtained from the farm to determine detection of BRD, NCD, and umbilical infections. Associations between probability of approach and BRD status were analyzed using a linear mixed model with a logit-transform (PROC GLIMMIX), controlling for calf as a random effect. All models controlled for week, pen, pen order, and test order. Calves with clinical signs of BRD on test day were 0.5 [95% confidence interval (CI) = 0.3-0.9] and 0.5 (95% CI = 0.3-0.9) times as likely to approach the OBJ and SH compared with healthy calves, respectively. Calves with a fever (rectal temperature ≥ 39.4°C) were 0.4 (95% CI = 0.2-0.8) and 0.4 (95% CI = 0.1-0.7) times as likely to approach the OBJ and SH compared with calves without fever, respectively. Calves that were recovering from NCD on test day, but were not showing clinical signs of NCD, were 0.4 (95% CI = 0.2-0.9) times as likely to approach SH, compared with healthy calves. These results suggest that approach tests may be useful for the identification of calves with clinical signs of BRD and calves with a fever in group housing.

The effect of respiratory disease and a preventative antibiotic treatment on growth, survival, age at first calving, and milk production of dairy heifers.

Bovine respiratory disease complex (BRD) is a common disease in weaned dairy calves that incurs economic and welfare costs. This study was an extension of a randomized clinical trial in which a single injection of tulathromycin (TUL) or oxytetracycline (TET) was administered at first movement to group housing for the prevention of BRD in the 60 d following antimicrobial treatment (BRD60). Calves treated with TUL were 0.5 times [95% confidence interval (CI): 0.4 to 0.7] as likely to be treated for BRD60 as calves treated with TET. The objectives of the current study were to evaluate the long-term effects of BRD and antibiotic treatment on growth of heifers until breeding age, age at first calving, incidence of dystocia, milk production, and mortality before first calving and mortality before 120 d in milk. At entry to the breeding barn (382 d of age), calves that experienced BRD60 weighed 16.0±2.3 kg less than calves that did not. Survival to first calving was recorded for 98% (1,343/1,392) of the heifers on this trial. For TET and TUL heifers with BRD60, 63% (94/150) and 73% (64/88) survived to first lactation, respectively. For TET and TUL calves without BRD60, 84% (436/517) and 84% (494/588) survived to first lactation, respectively. The median age at first calving for heifers with and without BRD60 was 714 (95% CI: 705-723) and 702 (95% CI: 699-705) days, respectively. Heifers with BRD60 were 1.5 (95% CI: 1.1-2.2) times more likely to have a calving ease score ≥2 at their first calving compared with heifers without BRD60. The administration of TUL at movement to group housing may have a role in the prevention of BRD and in mitigating some of the long-term effects of this disease.

The effect of treatment with long-acting antibiotic at postweaning movement on respiratory disease and on growth in commercial dairy calves.

Bovine respiratory disease (BRD) is a major concern when raising replacement heifers because of the high incidence and long-term effects of this disease, such as decreased growth and increased time to first calving. The objective of this study was to determine the effect of tulathromycin (TUL) treatment at postweaning movement on the incidence of BRD in dairy replacement heifers. A total of 1,395 heifers were enrolled between November 2006 and June 2007 at a commercial heifer-raising facility. Calves were randomly assigned either to treatment with TUL or to a positive control group treated with oxytetracycline (TET). Calves treated with TUL were 0.5 times (95% CI: 0.4 to 0.7) less likely to be treated for BRD in the 60 d following enrollment than calves treated with TET. For calves that had no history of BRD in the pre-enrollment period, TET calves weighed 4.9+/-0.5kg less than TUL calves after 6 wk in group housing. If calves were treated for BRD in the pre-enrollment period, there was no treatment effect on growth. Calves with clinical BRD in the 60 d following movement weighed 7.9+/-0.6kg less than calves without BRD after 6 wk in group housing. Treatment with TUL at the time of movement to group housing had a beneficial effect on the health and performance through the prevention of BRD in dairy calves with no prior history of the disease. Moreover, BRD after movement to group housing after weaning had a significant effect on the growth of dairy calves.

Expectancy-value constructs and expectancy violation as predictors of exercise adherence in previously sedentary women.

This prospective study examined effects of expectancy of exercise benefits, value of benefits, expectancy violation, and self-efficacy (SE) on exercise behavior and study dropout in sedentary women (n=86). SE predicted exercise for study completers but did not predict study dropout. After 6 and 12 weeks, participants evidenced expectancy violations, particularly for fitness and weight. Initial value, expectancy, and Expectancy X Value did not predict exercise for study completers, but dropouts had higher initial positive expectancies than did completers. Expectancy violations produced in Weeks 1-6 did not predict exercise in Weeks 7-12 in study completers, but dropouts in Weeks 7-12 had higher expectancy violations for weight in Weeks 1-6 than did completers. Follow-up revealed that study dropouts stopped exercising. Identifying individuals with high initial expectancies and expectancy violations may improve health behavior intervention and research.

Physician-assisted dying: review of issues and roles for health psychologists.

The authors review the recent empirical and theoretical literature on physician-assisted dying (PAD) since implementation of the Oregon Death With Dignity Act (ODDA) in 1997. The authors provide a brief overview of end-of-life practices; consider ethical and practical issues regarding PAD; outline governments' acts and health care organizations' current codified principles regarding PAD, including the American Psychological Association's goal to increase the visibility of psychology in end-of-life issues; examine recent data pertinent to ODDA implementation and psychologists' attitudes regarding PAD; and outline potential roles for health psychologists responding to requests for PAD and implementing PAD (where it is legal). Health psychologists can assume at least 4 roles regarding PAD: (a) policy advocates, (b) educators, (c) practitioners, and (d) researchers.

Form or function? Part 1. Subjective cosmetic and functional correlates of quality of life in women treated with breast-conserving surgical procedures and radiotherapy.

BACKGROUND: Quality of life (QOL) after a diagnosis of cancer varies considerably across individuals. Treatment-related factors that predict QOL for women who are diagnosed with breast carcinoma require further specification. This study was designed to develop a measure of perceived aesthetic (e.g., breast shape) and functional status (e.g., pain, mobility) after breast-conserving surgical treatment (BCT) and radiotherapy, to examine the relations of these indicators with patient QOL, and to determine whether these relations varied as a function of diagnosis duration. METHODS: Women (n = 185 patients) who underwent BCT and radiotherapy for Stage 0-II disease for whom the diagnosis duration ranged from 3 months to 18 years completed assessments of background information, perceived cosmetic and functional treatment outcomes, and QOL. Medical data also were obtained from medical charts. RESULTS: The Breast Cancer Treatment Outcome Scale (BCTOS) produced a coherent factor structure and three internally consistent subscales (i.e., cosmetic status, functional status, and breast specific pain) that demonstrated predictive validity. With patient age, diagnosis duration, and other BCTOS subscales controlled, greater breast specific pain predicted greater depressive symptoms (P < 0.01) and lower QOL related to mental health (P < 0.05) and physical health (P < 0.05). Cosmetic status predicted QOL related to physical health (P < 0.05). The relations of breast specific pain with QOL indicators varied somewhat as a function of diagnosis duration. CONCLUSIONS: Although considerable research on treatment-relevant outcomes has addressed appearance-related concerns, functional parameters have not been explored fully. Findings suggest that functional consequences of treatment, and particularly breast specific pain, also are significant influences on patient QOL.

Form or function? Part 2. Objective cosmetic and functional correlates of quality of life in women treated with breast-conserving surgical procedures and radiotherapy.

BACKGROUND: Treatment-related factors that influence quality of life (QOL) for women who are diagnosed with breast carcinoma require study. This study was designed to examine the convergent validity of objective and subjective indices of cosmetic and functional status after patients undergo breast-conserving treatment (BCT) and to test the relations of the objective indicators with QOL. METHODS: Women (n = 54 patients) who had received BCT and radiotherapy for Stage 0-II disease for whom the diagnosis duration ranged from 9 months to 18 years completed assessments of background information, perceived cosmetic and functional outcomes, and QOL. They also were administered a clinical breast examination, including objective ratings of arm edema and breast cosmesis. The patients were a subsample from the study reported by the authors in an accompanying article that is presented in this issue. RESULTS: The findings revealed positive cosmetic and functional treatment outcomes, such that 82% of patients had no or minimal arm edema, and 70% of patients evidenced good or excellent cosmetic results. Convergent validity was demonstrated for the objective and subjective assessments of cosmetic and functional treatment outcomes. In addition, women who had more arm edema reported poorer QOL with regard to depressive symptoms (P < 0.05) and fear of disease recurrence (P < 0.05). CONCLUSIONS: The findings from this study and those reported in the accompanying article reveal that functional treatment outcomes, such as arm edema and breast specific pain, are important correlates of QOL even many years after patients undergo BCT and radiotherapy. Both subjective and objective indicators of treatment outcomes are useful predictors of QOL.

Stress and reproduction: introduction to the special section.

This special section on stress and reproduction is devoted to an emerging frontier in interdisciplinary research that merits the attention of health psychologists. The majority of the studies concern the role of stress and emotion on birth outcomes such as low birth weight, fetal growth and preterm delivery, or mechanisms underlying these findings. The implications of this research extend from maternal and infant health to life-span development and adult health and mortality.

Emotionally expressive coping predicts psychological and physical adjustment to breast cancer.

This study tested the hypothesis that coping through emotional approach, which involves actively processing and expressing emotions, enhances adjustment and health status for breast cancer patients. Patients (n = 92) completed measures within 20 weeks following medical treatment and 3 months later. Women who, at study entry, coped through expressing emotions surrounding cancer had fewer medical appointments for cancer-related morbidities, enhanced physical health and vigor, and decreased distress during the next 3 months compared with those low in emotional expression, with age, other coping strategy scores, and initial levels on dependent variables (except medical visits) controlled statistically. Expressive coping also was related to improved quality of life for those who perceived their social contexts as highly receptive. Coping through emotional processing was related to one index of greater distress over time. Analyses including dispositional hope suggested that expressive coping may serve as a successful vehicle for goal pursuit.

Coping through emotional approach: scale construction and validation.

Four studies demonstrate the psychometric adequacy and validity of scales designed to assess coping through emotional approach. In separate undergraduate samples, exploratory and confirmatory factor analyses of dispositional (Study 1) and situational (Study 3) coping item sets yielded 2 distinct emotional approach coping factors: emotional processing (i.e., active attempts to acknowledge and understand emotions) and emotional expression. The 2 scales yielded high internal consistency and test-retest reliability, as well as convergent and discriminant validity. A study (Study 2) of young adults and their parents established the scales' interjudge reliabilities. Longitudinal (Study 3) and experimental (Study 4) research supported the predictive validity of the emotional approach coping scales with regard to adjustment to stressful encounters. Findings highlight the utility of functionalist theories of emotion as applied to coping theory.

Fostering ethical willingness: integrating emotional and contextual awareness with rational analysis.

Ethical dilemmas are inherently challenging. By definition, clinicians decide between conflicting principles of welfare and naturally confront competing pulls and inclinations. This investigation of students' responses to an ethical scenario highlights how emotions and concerns can interfere with willingness to implement ethical knowledge. Clear-cut rules are the exception in psychotherapy, and clinicians must judge ethical issues on the basis of the unique context of each case. As such, subjectivity and emotional involvement are essential tools for determining ethical action, but they must be integrated with rational analysis. Strategies for attending to influential emotions and contextual factors in order to mobilize ethical commitment are described.

Treatment decision making and adjustment to breast cancer: a longitudinal study.

This study monitored women (N = 76) with breast cancer from diagnosis through 1 year, and tested constructs from subjective expected utility theory with regard to their ability to predict patients' choice of surgical treatment as well as psychological distress and well-being over time. Women's positive expectancies for the consequences of treatment generally were maintained in favorable perceptions of outcome in several realms (i.e., physician agreement, likelihood of cancer cure or recurrence, self-evaluation, likelihood of additional treatment, partner support for option, attractiveness to partner). Assessed before the surgical decision-making appointment, women's expectancies for consequences of the treatment options, along with age, correctly classified 94% of the sample with regard to election of mastectomy versus breast-conserving procedures. Calculated from the point of decision making to 3 months later, expectancy disconfirmations and value discrepancies concerning particular treatment consequences predicted psychological adjustment 3 months and 1 year after diagnosis.

Efficacy of emotion-focused and problem-focused group therapies for women with fertility problems.

Competing positions exist in the literature regarding whether problem-focused or emotion-focused coping is more useful when one confronts a chronic health-related problem. In this study, 29 infertile women, who on average had been attempting conception for almost 4 years, were assigned to six sessions of training in problem- or emotion-focused coping or to a no-treatment control condition. Problem-focused training produced improvements in general distress and infertility-specific well-being at treatment termination. However, emotion-focused training resulted in greater improvement at a 1-months, follow-up. Emotion-focused participants reported less depression and more infertility-specific well-being at 1 month than did controls. At 18 months, problem-focused group members were more likely to have a child than were other participants. Results argue for the efficacy of both emotion-directed and problem-focused interventions in women's adjustment to infertility.

Coping through emotional approach: problems of conceptualization and confounding.

Two studies supported hypotheses that (a) published scales tapping coping through processing and expressing emotion are confounded with psychopathology; (b) previously demonstrated relations between emotional approach coping (EAC) and maladjustment are partially spurious; and (c) EAC, when tapped by items uncontaminated by distress, is beneficial under specific conditions. In Study 1, 194 psychologists rated a majority of published items, but no author-constructed EAC item, as indicative of pathology. Study 2 assessed relations of confounded and unconfounded EAC scales to 171 young adults' adjustment during stressful events. Confounded items evidenced weaker discriminant validity with distress measures than did unconfounded items, and they were weaker predictors of later maladjustment when initial adjustment was controlled than when it was not. Unconfounded EAC predicted improved adjustment for women and poorer adjustment for men over time.

Evaluation of relapse prevention and reinforcement interventions to promote exercise adherence in sedentary females.

An experimental design was employed to assess the effectiveness of a relapse prevention program, a reinforcement program, and an exercise-only control group in increasing exercise program adherence and short-term maintenance in 120 previously sedentary female university employees. The subjects participated in an 18-week exercise program composed of stretching, calisthenics, and aerobic dance. Attendance during the first half of the program was significantly higher for subjects in the relapse prevention group than for those in the control group. A nonsignificant trend in this direction emerged during the second half of the program and at 2-month follow-up. For all treatment groups, attrition (attendance at less than two thirds of the exercise sessions) was substantial, averaging 72% at the end of the 18-week program. These findings indicate that relapse prevention and reinforcement programs may not assist previously sedentary females in long-term adherence to an exercise program.

Coping with a breast cancer diagnosis: a prospective study.

Employing the stress and coping theory of Lazarus and Folkman, this study followed 117 women age 40 or over regarding personality, cognitive appraisal, coping, and mood variables before breast biopsy, after diagnosis, and, for those who had cancer, after surgery. Upon biopsy, 36 received a cancer diagnosis, and 81 received a benign diagnosis. The 2 groups did not differ on appraisals, coping, or affect before diagnosis. With prebiopsy affect controlled, cancer patients reported more negative affect postbiopsy than did benign patients. Postsurgery, cancer patients expressed less vigor and more fatigue than benign patients, but the groups did not differ on other negative emotions. Prebiopsy, psychosocial predictors accounted for 54% and 29% of the variance in negative and positive emotion, respectively. Prebiopsy variables also predicted postbiopsy and postsurgery mood; cognitive avoidance coping was a particularly important predictor of high distress and low vigor.

Preparation of children for emergency medical care: a primary prevention approach.

Increased emergency room use and the resulting rise in pediatric visits have prompted interest in psychological aspects of pediatric emergency care. This study evaluated the efficacy of a multicomponent hospital program designed to prepare children for emergency room visits. In Phase 1, 148 kindergarteners completed measures of medical fears and knowledge at pretreatment, posttreatment, and a 4-week follow-up. Program attenders had significantly fewer medical fears and higher medical knowledge at posttest and follow-up than control children. The program was more effective for black than white children. In Phase 2, 51 high-fear children from Phase 1 were selected randomly to attend a medical examination in an emergency room. No effects for program emerged on the observational distress measures or physiological arousal. Phase 2 children showed significantly increased medical knowledge at follow-up compared to children who did not receive the medical exam.

Influence of personality attributes and daily moods on bulimic eating patterns.

Relationships among personality attributes, mood states, and eating patterns were examined in a nonclinical sample of females with bulimic symptomatology and binge eaters. Thirteen subjects in each group completed trait measures of depression, anxiety, hostility, and locus of control. Subsequently, they self-monitored affect and eating patterns over a 20-day period. Greater state depression, anxiety, and hostility all were associated significantly with subsequent daily binge eating, and with purging for bulimic subjects. The association of binge occurrence with state anxiety and hostility was significantly greater for bulimics than for binge eaters. Locus of control and trait hostility were important in influencing reactivity of binge eating to daily moods. As trait hostility and externality increased, reactivity of binges to negative mood states also increased.