ABSTRACT
With regard to acute toxicity, the cubosols are attributed to the non-cumulative compounds of low toxicity. Acute inhalation exposure threshold for cubosol "Bright green" is over 140 mg/m3. Subacute poisonings developed following intragastric administrations in concentrations 1 g/kg for 30 days, and were characterized by polymorphism of the signs. Revealed were delayed body mass increment in the laboratory animals, changes in peripheral blood and hepatorenal morphology and function.
Subject(s)
Air Pollutants, Occupational/toxicity , Benz(a)Anthracenes/toxicity , Coloring Agents/toxicity , Organic Chemicals , Air Pollutants, Occupational/poisoning , Animals , Benz(a)Anthracenes/poisoning , Coloring Agents/poisoning , Lethal Dose 50 , Maximum Allowable Concentration , Mice , Poisoning/etiology , Poisoning/physiopathology , Rabbits , Rats , Time FactorsABSTRACT
Mutagenic activity of inhaled dispersed orange 2K nitrodye (DON 2K) and Reax' disperser was evaluated. Chronically inhaled DON 2K (with disperser) in concentration 28.6 mg/m3 is a genetic danger for an individual and population, being also a selective by injurious++ to the red blood cells. Chronically inhaled Reax' disperser (25.7 and 5.8 mg/m3) shows low mutagenic activity in somatic tissue. Thus, the mutagenic effect of DON 2K with disperser (composition is constant) is explained by nitrodye and not a disperser.