SYNCHRONOUS HAIRY CELL LEUKEMIA AND HEPATOCELLULAR CARCINOMA: A CASE REPORT.

Multiple primary malignant tumors are characterized by independent occurrence and development of two or more malignant neoplasms in the same patient. We present an extremely rare case of synchronous double primary malignancies, hairy cell leukemia and hepatocellular carcinoma with lethal outcome. Diagnosis of hepatocellular carcinoma was difficult due to the presence of lymphoproliferative disease, which complicated the visualization of the process using ultrasonography. Carcinomatous emboli of hepatocellular carcinoma in small pulmonary arteries without the formation of metastatic foci have led to clinical manifestations typical of pulmonary embolism, pulmonary hypertension and severe respiratory failure. In lymphoproliferative diseases it is necessary to take into account the possibility of the development of another malignant neoplasm, which can be "buried" by tumor infiltration.

Clinicomorphological observation of refractory hepatoblastoma: a case report.

The clinical case of refractory hepatoblastoma with lethal outcome followed by pathomorphological verification has been analyzed. The true causes of hepatoblastoma development remain unknown. The prognostic factors of the disease require detailed study in complex investigations that would include histological, clinical, laboratory, and immunohistochemical characteristics. However, comparing clinical and histopathological parameters with CD10 expression could have a diagnostic role and may be useful in understanding tumorigenesis and prognostic analysis of a given tumor.

The observation of congenital retroperitoneal large size neuroblastoma.

The article represents current literature data on epidemiological, clinical-morphological features and diagnostic criteria of neuroblastoma. The case of large congenital neuroblastoma with multiple metastases in the newborn child is presented. The histological picture and immunohistochemical profile of the tumor allowed us to consider this type of neuroblastoma as the least differentiated variant (subtype, "neuroblastoma rich in Schwann stroma"), with rapid progression and metastasizing started before the birth of the child.

THE IMPACT OF THE ACRYLIC MONOMER ON THE MORPHOLOGICAL STRUCTURE OF RAT LINGUAL MUCOSA.

The analysis of publications shows that diverse multiple factors can induce changes in taste sensitivity and the main irritants are the chemicals of different types. However, the study of the effect of the components of dental structural materials on the state of lingual mucosa, in particular, taste sensors, has not been fully elucidated to date. The purpose of the paper was the study of the effect of monomer of the "Ftoraks" base acrylic resin on the state of the rats' lingual mucosa within 2-4 weeks after its impact. The previous paper [5] presents the findings of the study on the impact of the monomer of the "Ftoraks" base acrylic resin on the state of the rats' lingual mucosa in the early period (1 to 7 days) and its subsequent regeneration. The studies have found that the greatest changes in the lingual mucosa occur on day 3 and 7 after the application of monomer, and are of erosive-inflammatory origin. Regeneration of the lingual epithelium is delayed. The studies confirm that the monomer of acrylic resin causes a number of pathological changes in the mucous membrane and muscles of the rat tongue, the nature of which varies depending on the duration of its impact. On day 14 in the lingual mucosa the destructive processes are significantly delayed, substituting for the sclerotic processes in the proper plate and atrophic processes, observed, first of all, in the papillae of the tongue. It is appropriate to assume that such changes in the papillae will lead to violation of the taste reception, first of all, in the areas of lateral surfaces of the body of the tongue and in the root area. At the same time, it should be noted that at the end of the experimental period (on day 28 of the contact of the monomer with the lingual mucosa), in the mucous membrane of the tongue, along with atrophic and sclerotic processes, the destructive changes and inflammatory reaction are evident. We hypothesize that this may indicate about partial recovery of taste sensitivity due to the decrease in the number of gustatory buds, taste papillae of different types and the increase in the period of their regeneration.

[A case of primary diffuse large B-cell lymphoma of the brain]. / Nabliudenie pervichnoi diffuznoi B-krupnokletochnoi limfomy golovnogo mozga.

The paper describes a case of primary extranodal diffuse large B-cell lymphoma of the cerebral hemispheres, which was regarded as an inflammatory disease of the brain during life and diagnosed only posthumously in the microscopically examination of the autopsy material by immunohistochemical studies.

Special Grain Boundaries in Ultrafine-Grained Tungsten.

Field ion microscopy and computer simulation were used for the study of an atomic structure high-angle grain boundary in hard-drawn ultrafine-grained tungsten wire. These boundaries with special misorientations are beyond the scope of the coincident site lattice model. It was demonstrated that the special non-coincident grain boundaries are the plane-matching boundaries, and rigid-body displacements of adjacent nanograins are normal to the <110> misorientation axis. The vectors of rigid-body translations of grains are described by broad asymmetric statistical distribution. Mathematical modeling showed that special incommensurate boundaries with one grain oriented along the {211} plane have comparatively high cohesive energies. The grain-boundary dislocations ½<110> were revealed and studied at the line of local mismatch of {110} atomic planes of adjacent grains.

[MORPHOLOGICAL FEATURES OF RAT MUCOUS MEMBRANE OF THE TONGUE EARLY AFFECTED BY ACRYLIC RESIN MONOMER].

Base materials, made on the basis of various derivatives of acrylic and methacrylic acids, have been widely used in prosthetic dentistry. Free monomer, affecting the tissues of prosthetic bed and the whole body, is always found in dentures. Therefore, study of the effect of acrylic resins' monomer on mucous membrane of the tongue is crucial. Rat tongue is very similar to human tongue, and this fact has become the basis for selecting these animals to be involved into the experiment. The paper presents the findings related to the effect of "Ftoraks" base acrylic resin monomer on the state of rat mucous membrane of the tongue and its regeneration. The microscopy has found that the greatest changes in the mucous membrane of the tongue occur on day 3 and 7 day after applying the monomer and are of erosive and inflammatory nature. Regeneration of tongue epithelium slows down.

EXPERIMENTAL-MORPHOLOGICAL SUBSTANTIATION OF EXPEDIENCY TO USE THE SKIN GLUE "DERMABOND" FOR POSTOPERATIVE WOUND CLOSURE.

We aimed to investigate the morphological features of healing of postoperative wounds in the early stages of reparative process in the experiment, depending on the used type of the wound closure. It is proved that the nature and type of the scar depends on the processes that occur in the wound at the early postoperative stage, which in turn greatly affects the form of suture material used. The experiment included 20 male rats, weighing 180-200 g. All rats were anesthetized by a single intraperitoneal injection of sodium thiopental. After the shaving operative field, 2 cm full-thickness incision wound was made on the anterior surface of the abdomen in the longitudinal direction. As suture material for wound closure in the 1st experimental group (10 rats) we used surgical filament "Polyamide 4-0¼. In the 2nd experimental group (10 rats) wounds were closured by using skin glue "Dermabond". According from our experiment, the usage of skin glue creates better conditions for wound healing. Thus, to achieve a more aesthetic scar, we recommend applying skin glue instead of using nodal joints.

[Structure of teeth in mature ovarian teratoma].

MATERIAL AND METHODS: The authors investigated three mature ovarian dermoid cysts that were found to contain atypically developed teeth (one tooth in one cyst; 2 teeth in another cyst, and a set of 8 teeth with jawbone fragments in the third one). Their structure was examined using the epoxy resin plastination technique to obtain plastinated sections. RESULTS: Some of these teratomous teeth have obvious signs of alteration in both dentin and enamel, which may be referred to as fluorosis or macular enamel hypoplasia in one case whereas other sections indicate a caries lesion. CONCLUSION: These facts are contradictory to the concept of the exogenous nature of dental caries, which is accepted in dentistry.

[Enamel structure of atypically formed human teeth].

Using light and scanning electron microscopy thin epoxide processed sections of 12 impacted third molars, one molar developed in odontogenic follicular cyst and one tooth-like teratoma were studied. It was established that the 4 impacted teeth and the tooth developed in odontogenic follicular cyst had obvious signs of enamel damage in the form of erosion in the crown fissures. The features of enamel alteration make it possible to interpret the changes as carious process which apparently has endogenous origin. Tooth-like teratoma extracted from ovarian dermoid cyst looked like canine and incisor "hybrid" coronal portion of which is covered with thin enamel layer, marked by obvious signs of multiple erosive lesions of endogenous nature. But unlike alterations in impacted teeth it resembles either fluorosis or enamel hypoplasia.

A method for making histological preparations equivalent to semithin sections with large examination areas for multipurpose morphological studies.

Effective methods for making semithin sections of large surface area are not currently available. An alternative solution to this problem, without actual histological section preparation, is proposed. This is a modification of a combination of methods for fixing tissues and embedding them in epoxide resin using known technical methods. This method for making preparations for microscopic examination of biological objects with large surface areas has additional valuable potential, as it allows investigations of a variety of complexes of soft and hard (cartilaginous and bony) tissues without prior decalcination.

[Method of producing histological preparations, equivalent to the large-area semithin sections, for multipurpose morphological studies].

The effective methods for producing large-area semithin sections are presently still unavailable. The method is suggested to alternatively solve this problem without the very procedure of histological sectioning. It includes a modified combination of the methods of tissue fixation and embedding in epoxy resin with the known technique of preparing the ground sections. This method of slide preparation for the microscopical study of large area biological objects gives an additional valuable opportunity, since it allows to study heterogeneous complexes consisting of soft and hard (cartilaginous and bone) tissues without their prior decalcination.