1.
Zh Nevrol Psikhiatr Im S S Korsakova
; 112(3 Pt 1): 39-43, 2012.
Article
in Russian
| MEDLINE
| ID: mdl-22677754
ABSTRACT
We conducted a comparative study on the effect of active compounds of pantogam and pantogam active (calcium D(R)-homopantothenate and calcium DL(RS)-homopantothenate) and its L(S)-isomer on the receptors of main brain neuromediators in rats using in vitro radioligand binding analysis. All three compounds interact with binding sites of specific GABA-A and, in particular, GABA-B receptor ligands. Racemate and S-enantiomer, but not its R-form, competed to a moderate degree for D2-receptor binding sites. In all cases, degrees of interaction with receptors were ranged as follows: S-isomer>racemate>R-isomer. These qualitative and quantitative differences are assumed to contribute to pharmacological activity of both drugs.
Subject(s)
Brain/drug effects , Pantothenic Acid/analogs & derivatives , Receptors, Dopamine D2/metabolism , Receptors, GABA-A/metabolism , Receptors, GABA-B/metabolism , gamma-Aminobutyric Acid/analogs & derivatives , Animals , Brain/metabolism , Pantothenic Acid/chemistry , Pantothenic Acid/pharmacokinetics , Pantothenic Acid/pharmacology , Radioligand Assay , Rats , Stereoisomerism , gamma-Aminobutyric Acid/chemistry , gamma-Aminobutyric Acid/pharmacokinetics , gamma-Aminobutyric Acid/pharmacology
2.
Biokhimiia
; 31(5): 881-6, 1966.
Article
in Russian
| MEDLINE
| ID: mdl-6001324