[Familial hemiplegic migraine]. / Semeinaya gemiplegicheskaya migren'.

Hemiplegic migraine (HM) is a rare subtype of migraine with aura which prevalence is about 0.01%. The characteristic features include motor symptoms (hemiparesis) along with the signs of migraine with typical aura (visual, sensory and/or speech disturbances). The diagnosis of familial hemiplegic migraine (FHM) is established when at least 1 or more relatives of the 1st or 2nd degree in the family have the attacks of HM. This report describes a family in which two members (father and daughter) develop attacks of severe headache with nausea and, sometimes, vomiting, accompanied by visual disturbances, speech impairment, followed by unilateral numbness and weakness of extremities. The diagnosis of FHM was established. The report includes the review of literature and the discussion of some aspects of differential diagnosis.

[Etiopathogenesis of obstructive sleep apnoea and its consequences in the children]. / Étiopatogenez obstruktivnogo apnoé sna i ego posledstvii u detei.

The article presents the modern view of etiology of the obstructive sleep apnoea/hypopnoea syndrome (OAHSS) in the children taking into consideration the ontogenetic stage and the principal mechanisms of its formation including the short-term and long-term consequences of sleep apnoea with special reference to the pathogenetic commonness of OAHSS with endothelial dysfunction, metabolic syndrome, cardiac disorders, and systemic chronic inflammation. The role of ENT diseases in the children with obstructive sleep apnoea is discussed. The results of genetic studies of the processes influencing the formation of the risk of development of sleep apnoea/hypopnoea syndrome and its outcomes in the children are discussed.

[Clinical efficacy of cytoflavin in the combined treatment of patients during acute phase of ischemic stroke].

This study investigated efficiency of cytoflavin in combined treatment of acute hemisphere or stem stroke. It included 35 patients aged 40-70 years with the newly diagnosed mild and moderate stroke. The main group comprised 29 patients treated with cytoflavin (10 ml twice daily by i/v drop infusion for 10 days) in addition to basal therapy. Controls (n=15) were given basal therapy alone. All patients were examined on days 1 and 15 for the evaluation of their neurological status, neuropsychological testing, assessment of cognitive function (from the ability to remember 10 words), everyday activities, and quality of life (based on the QOL scale). Evaluation of the neurological status by the NIHSS scale on day 15 after the onset of therapy revealed its positive dynamics. Indicators of functional normalization in groups 1 and 2 were significantly different. Analysis of social and functional activities on day 15 demonstrated a higher Bartel index in patients given cytoflavin. Moreover these patients showed significant improvement of short- and long-term memory as well as the highest health index. The MMSE test did not reveal significant difference between the two groups on day 15 (p > 0.05). It is concluded that cytoflavin therapy significantly improved the health status of the patients. It proved efficacious as regards correction of motor and non-motor symptoms in patients having acute ischemic stroke.

[Clinical features of migraine and parameters of trigeminal somatosensory evoked potentials in patients with different levels of thyroid-stimulating hormone].

UNLABELLED: Levels of thyroid-stimulating hormone (TSH), trigeminal somatosensory evoked potentials (TSEPs) and quality of life (QoL) were studied in 50 migraine patients and 10 healthy subjects. The latency of P1 as well as the asymmetry of P1 latency and N1P1 amplitude were enlarged in migraine patients. Lower levels of TSH were correlated with more pronounced asymmetries in TSEPs. QoL in migraine was inversely correlated with TSH levels, pain intensity, MIDAS score, passive strategies preference, levels of anxiety and depression. IN CONCLUSION: TSH levels may modulate the function of trigeminal system in migraine.

[The alterations of lipid spectrum in patients with migraine]. / Izmeneniia lipidnogo spektra u bol'nykh migren'iu.

The paper presents lipid spectrum in 40 patients aged 19-50 years with migraine. Migraine is one of the possible causes of stroke development at young age. There were found significant atherogenic changes of blood serum lipid spectrum, which didn't depend on clinical peculiarities of the disease, but became more pronounced as far as the level of the situational anxiety (according to Spilberger's questionnaire) increased. It is suggested that the changes in lipid spectrum may be some components in complex alterations of the functions of structures of limbic-reticular complex and humoral-endocrine homeostasis which are both genetically determined and acquired. These changes are quite important in pathogenesis of migraine and may be considered as the risk-factors of the development of cerebral stroke at young age.