ABSTRACT
The influence of newly synthesized compound--thiazoline ammonium 4-chlorophenyl-2-hydroxy-4-oxo-2-butenoate (FS-169), which has a direct anticoagulant--on the indices of coagulation activity has been studied in rabbit blood plasma with the aid of an APG4-02-P coagulometer. It is established that FS-169 reliably extends the partial thromboplastin time by 122.2% (p < 0.001) and the prothrombin time by 49.1% (p = 0.001), increases the prothrombin index by 30.9% (p = 0.001), and decreases the prothrombin ratio and international normalized ratio by 40.0% (p = 0.001). At the same time FS-169 does not influence the thrombin time FS-169.
Subject(s)
Acetates/pharmacology , Anticoagulants/pharmacology , Benzene Derivatives/pharmacology , Blood Coagulation/drug effects , Prothrombin Time , Vinyl Compounds/pharmacology , Animals , RabbitsABSTRACT
The contribution of multiple scattering to a spaceborne lidar return from clear molecular atmosphere obscured by transparent upper-level crystal clouds is assessed by the use of the variance-reduction Monte Carlo technique. High anisotropy of scattering in the forward direction by polydispersions of ice crystals is the basis of a significant effect of multiple scattering for small values of the lidar receiver field of view. Because of scattering by large nonspherical crystal particles, the lidar signal backscattered from the molecular atmosphere under the cloud increases significantly compared with the single-scattering return. The ratio of the multiple-to-single-scattering contributions from the clear atmosphere hidden by the clouds is greater than from the crystal clouds themselves, and it is proportional to the values of cloud optical thickness.
