ABSTRACT
In the course of photodynamic treatment with supernatants of Laminaria japonica and Fucus sp the former was found to significantly inhibit the growth of experimental tumor M-1.
Subject(s)
Fucus , Laminaria , Photochemotherapy/methods , Sarcoma, Experimental/drug therapy , Animals , Male , Rats , Rats, WistarABSTRACT
The study was concerned with the effects of brown seaweeds on hemostasis and sarcoma M-1 growth in rats. Laminaria japonica and focus were shown to exert anticoagulant action to inhibit carcinogenesis. They may be used for adjuvant therapy of tumors.
Subject(s)
Fucus , Hemostasis/drug effects , Laminaria , Plant Extracts/pharmacology , Sarcoma, Experimental/drug therapy , Animals , Female , Plant Extracts/therapeutic use , Rats , Rats, Wistar , Sarcoma, Experimental/physiopathologyABSTRACT
Noninbred rat experiments with M-1 tumor have found that combination of fenylin with photodynamic therapy produced a 1.5-fold slowing down in the growth of the tumor compared to the control animals on day 15 and 21 after the treatment.
Subject(s)
Anticoagulants/therapeutic use , Neoplasms/drug therapy , Phenindione/therapeutic use , Photochemotherapy/methods , Animals , Anticoagulants/pharmacology , Cell Line, Tumor , Hemostasis/drug effects , Phenindione/pharmacology , Rats , Xenograft Model Antitumor AssaysABSTRACT
In experiments on mice F1 total exposed to gamma-irradiation at the 5.0 Gy, showed that a intraperitoneal injection neogen at the dose 10 micrograms/kg oue time at the day and night during the 8 days after irradiation results in recovery of the number blood platelets and time issue of blood from standard wound to normal level on the week by compare with irradiated control animals.
Subject(s)
Adjuvants, Immunologic/therapeutic use , Radiation Injuries, Experimental/drug therapy , Thrombopoiesis , Adjuvants, Immunologic/administration & dosage , Animals , Cobalt Radioisotopes , Data Interpretation, Statistical , Injections, Intraperitoneal , Mice , Mice, Inbred C57BL , Mice, Inbred CBA , Platelet Count , Radiation Dosage , Radiation Injuries, Experimental/blood , Radiation Injuries, Experimental/immunology , Radiation Injuries, Experimental/physiopathology , Thrombopoiesis/drug effects , Thrombopoiesis/radiation effects , Thrombopoietin/physiology , Time FactorsABSTRACT
The experiments on Wistar rats and mice (C57B16)F1 exposed to gamma irradiation at the doses of 4,5 to 7,5 Gy, alone and in combination with a III-B skin burn of 10-30% skin surface, showed that a combined injury results in a higher death rate. On a background of the bone marrow hemocytogenesis depression, a syndrome of disseminated intravascular blood coagulation and the irradiation-induced hemorrhagic syndrome develop. It was shown that the bone marrow depression and hemostasis disorders play an important role in the thanatogenesis of a combined radiation and thermal injury. The problems of diagnosis and therapy are discussed.
Subject(s)
Burns/blood , Hemostasis/radiation effects , Radiation Injuries, Experimental/blood , Skin/injuries , Acute Disease , Animals , Blood Coagulation Tests , Burns/mortality , Female , Gamma Rays , Male , Mice , Mice, Inbred C57BL , Mice, Inbred CBA , Radiation Injuries, Experimental/complications , Radiation Injuries, Experimental/mortality , Rats , Rats, Wistar , Time FactorsABSTRACT
The effect of berberin sulfate (single and chronic administration during 30 days in doses of 0.14-80 mg/kg) on the functional state of hemostasis system was studied on gamma-irradiated (dose 5.0 Gy) and intact Wistar rats and mice (CBA x C57BL)F1. Administration of the drug increases the number of thrombocytes, decreases the activity of factor XIII and promote blood coagulation.
