[Circulating immune complexes and immunoglobulins A, M and G in the mother-fetus system in normal pregnancy and gestosis]. / Tsirkuliruiushchie immunnye kompleksy i immunoglobuliny A, M, G v sisteme mat'-plod pri fiziologicheskoi beremennosti i gestoze.

Circulating immune complexes (CIC) and immunoglobulins A, M, and G were measured in the maternal peripheral blood, mixed umbilical blood, and amniotic fluid in women with normal pregnancy and gestosis. CIC concentrations in the examined fluids did not surpass the levels typical of healthy donors. Maternal blood CIC levels were higher in gestosis than in normal pregnancy, and CIC levels in the umbilical blood and amniotic fluid were always lower than in maternal blood serum. IgG levels were found the most shifted. These data evidence changes of the humoral immunity in normal pregnancy, this being, probably, one of the mechanisms providing its favorable course.

[Immunological properties of the amniotic fluid in physiological pregnancy and gestoses]. / Immunologicheskie svoistva okoloplodnoi zhidkosti pri fiziologicheskoi beremennosti i gestozakh.

Immunologic analysis of the amniotic fluid included measurements of immunoglobulins A and M, circulating immune complexes, rheumatoid and antinuclear factors, immunophoresis and electrophoresis, and tests for the presence of donor lymphocytes, Changed immunologic parameters of the amniotic fluid indicate a complicated course of pregnancy, development of gestosis among other things. Basing on their findings, the authors suggest that gestosis involve dysfunction of the adaptive mechanisms, that may result from disordered interactions of the immunity system components.

[Analysis of plasma levels of dehydroepiandrosterone and 17-hydroxyprogesterone in physiologic and pathologic pregnancy and labor]. / Dinamicheskoe opredelenie kontsentratsii degidroépiandrosterona i 17-oksiprogesterona v plazme krovi pri fiziologicheskom i patologicheskom techenii beremennosti i rodov.

Plasma levels of dehydroepiandrosterone (DEA) and 17-hydroxyprogesterone (17-HP) were studied in 43 pregnant females 11 with normal pregnancy and labor and 32 at high risk of obstetric complications (primary powerless labor, prematurity, postmaturity, rapid parturition). Hormonal investigation was performed in each particular female in the time-course of her pregnancy and labor as well as in the mixed blood plasma from the umbilical cord. Concentrations of hormones observed in the females with normal pregnancies and labors differed from those in the patients whose pregnancy was complicated as well as their labor. It has been concluded that the results of DEA and 17-HP variation assessment in the blood plasma are essential additional indicators of adrenal performance both in mother and fetus.

[Mortality after cesarean section]. / Letal'nost' posle operatsii kesareva secheniia.

PIP: The results of cluster analysis of maternal mortality after cesarean section in the USSR are reported. The statistical data were collected for the 1980-1986 period for USSR in total and for various regions. Region A included Baltic republics and Byelorussia; region B included Russia, Ukraine, Armenia and Moldavia; region C included Uzbekistan, Kazakhstan, Kirgizia, Azerbaijan, and Georgia; and region D included Tadzhikistan and Turkmenia. In the USSR, cesarean section was performed in 1.6-3.1% of all pregnancies (2.4-4.6%, 1.8-3.7%, 0.9-1.9%, and 0.8- 1.5% in regions A, B, C and D, respectively). Mortality rate after cesarean section was 0.4-0.2% for the USSR (0.09-0.08%, 0.35-0.10%, 0.80-0.40%, and 1.60-0.50% for regions A, B, C and D, respectively). Indications for cesarean section included abruptio placentae (34.2%), late toxemia (22.9%), cicatrix in the uterus (8.7%), narrow pelvis (8.7%), anomaly of labor activity (8%), extragenital pathology (5.8%), placenta previa (5.1%), fetal distress (3.6%), and others (3%). Emergency cesarean section was performed in 90% of the patients (only 18% underwent emergency cesarean section within 1 hour after the diagnosis). The most frequent cause of death after cesarean section was hemorrhage (36.2%). The 2nd leading cause of death was late toxemia (17.5/%). Other causes of death included cerebral hemorrhage (8.1%), brain edema (9.8%), complications of anesthesia (9.5%), extragenital diseases (7.7%), and hypotonia of the uterus (5.6%).^ieng