ABSTRACT
In this review, the authors consider endothelial dysfunction as a key pathophysiologic event of chronic vascular encephalopathy. Possible mechanisms of endothelial dysfunction in chronic vascular encephalopathy, especially associated with cerebral small vessel disease, neuroanatomy and pathophysiology of cerebral vascular endothelium are considered. Laboratory and instrumental methods for the diagnosis of endothelial dysfunction and potential approaches to its correction are described.
Subject(s)
Brain Diseases , Cerebrovascular Circulation , Endothelium, Vascular , Brain Diseases/physiopathology , Endothelium, Vascular/physiopathology , HumansABSTRACT
The article considers new approaches to diagnosis, treatment and rehabilitation of patients with arterial hypertension (AH) applied to the Ministry of Defence contingent. For the medical service of the Armed Forces the problem is relevant because of the significant labor losses, high level of dismission, morbidity and mortality of this disease. In the assessment of the patients limitation of life should be considered a variant AH, the stage, availability and seventy of the organ damage, severity and reversibility of complications, the incidence and severity of hypertensive crises, the effectiveness of treatment, comorbidity, education, occupation, the presence of contra-types and conditions of military service or labor. Military medical expertise of soldiers with AH uses the classification of degrees of arterial hypertension of 2010 and a three-stage-classification hypertonic disease created by the World Health Organization, 1996.
