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1.
Dev Med Child Neurol ; 66(5): 610-622, 2024 May.
Article in English | MEDLINE | ID: mdl-37650571

ABSTRACT

AIM: This study describes the process of updating the cerebral palsy (CP) common data elements (CDEs), specifically identifying tools that capture the impact of chronic pain on children's functioning. METHOD: Through a partnership between the American Academy for Cerebral Palsy and Developmental Medicine and the National Institute of Neurological Disorders and Stroke (NINDS), the CP CDEs were developed as data standards for clinical research in neuroscience. Chronic pain was underrepresented in the NINDS CP CDEs version 1.0. A multi-step methodology was applied by an interdisciplinary professional team. Following an adapted CP chronic pain tools' rating system, and a review of psychometric properties, clinical utility, and compliance with inclusion/exclusion criteria, a set of recommended pain tools was posted online for external public comment in May 2022. RESULTS: Fifteen chronic pain tools met inclusion criteria, representing constructs across all components of the International Classification of Functioning, Disability and Health. INTERPRETATION: This paper describes the first condition-specific pain CDEs for a pediatric population. The proposed set of chronic pain tools complement and enhance the applicability of the existing pediatric CP CDEs. The novel CP CDE pain tools harmonize the assessment of chronic pain, addressing not only intensity of chronic pain, but also the functional impact of experiencing it in everyday activities.


Subject(s)
Biomedical Research , Cerebral Palsy , Chronic Pain , Child , Humans , United States , Common Data Elements , National Institute of Neurological Disorders and Stroke (U.S.) , Chronic Pain/diagnosis , Chronic Pain/therapy , Cerebral Palsy/complications
2.
Front Rehabil Sci ; 3: 811509, 2022.
Article in English | MEDLINE | ID: mdl-36189020

ABSTRACT

Background: Compared to unilateral cerebral palsy (CP), less is known about brain reorganization and plasticity in bilateral CP especially in relation or response to motor training. The few trials that reported brain imaging results alongside functional outcomes include a handful of studies in unilateral CP, and one pilot trial of three children with bilateral CP. This study is the first locomotor training randomized controlled trial (RCT) in bilateral CP to our knowledge reporting brain imaging outcomes. Methods: Objective was to compare MRI brain volumes, resting state connectivity and white matter integrity using DTI in children with bilateral CP with PVL and preterm birth history (<34 weeks), to age-related controls, and from an RCT of intensive 12 week rapid-reciprocal locomotor training using an elliptical or motor-assisted cycle. We hypothesized that connectivity in CP compared to controls would be greater across sensorimotor-related brain regions and that functional (resting state) and structural (fractional anisotropy) connectivity would improve post intervention. We further anticipated that baseline and post-intervention imaging and functional measures would correlate. Results: Images were acquired with a 3T MRI scanner for 16/27 children with CP in the trial, and 18 controls. No conclusive evidence of training-induced neuroplastic effects were seen. However, analysis of shared variance revealed that greater increases in precentral gyrus connectivity with the thalamus and pons may be associated with larger improvements in the trained device speed. Exploratory analyses also revealed interesting potential relationships between brain integrity and multiple functional outcomes in CP, with functional connectivity between the motor cortex and midbrain showing the strongest potential relationship with mobility. Decreased posterior white matter, corpus callosum and thalamic volumes, and FA in the posterior thalamic radiation were the most prominent group differences with corticospinal tract differences notably not found. Conclusions: Results reinforce the involvement of sensory-related brain areas in bilateral CP. Given the wide individual variability in imaging results and clinical responses to training, a greater focus on neural and other mechanisms related to better or worse outcomes is recommended to enhance rehabilitation results on a patient vs. group level.

3.
Nurs Outlook ; 70(4): 616-624, 2022.
Article in English | MEDLINE | ID: mdl-35513900

ABSTRACT

BACKGROUND: DNP Scholarly projects require review for scientific merit and human subject protection. Rapid growth of DNP programs and projects has increased Institutional Review Board (IRB) burden and increased the length of project approval time when most DNP scholarly projects are quality improvement (QI) projects and not deemed Human Subjects Research (HSR). PURPOSE: Develop a process and describe the rationale for creating and implementing a Project Ethical Review Committee (PERC) in the School of Nursing and to evaluate the experience of the first cohort of submissions. PROCESS: Committee was formed using expert consensus approach, in collaboration with IRB. Standards of Procedures and training materials created. OUTCOME MEASURE: 100 projects submitted to committee; 95 deemed QI (95%) and 5 projects considered HSR (5%). First 94 projects were reviewed, and approval letters sent within 8 weeks. DISCUSSION: This paper discusses how PERC ensures rigorous and ethical review process for standardization, timeliness, and efficiency.


Subject(s)
Education, Nursing, Graduate , Students, Nursing , Ethical Review , Ethics Committees, Research , Humans , Reference Standards
4.
Front Pain Res (Lausanne) ; 1: 553026, 2020.
Article in English | MEDLINE | ID: mdl-35295692

ABSTRACT

Chronic pain is prevalent in adults with cerebral palsy. We aimed to explore associations between chronic pain and somatosensory, motor, cognitive, etiologic, and environmental factors in adults with cerebral palsy. This cross-sectional study enrolled 17 adult participants with cerebral palsy (mean age 31 years; 8 female; Gross Motor Functional Classification Status levels I-V) able to self-report and 10 neurotypical adult volunteers (mean age 34 years; 9 female). Participants reported pain characteristics, demographics, and affective factors. Physical examination included somatosensory and motor evaluation. Between-group comparisons used a ranksum test, and correlation analyses estimated effect size in terms of shared variance (ρ2). Individuals with cerebral palsy reported greater pain intensity, neuropathic qualities, and nociceptive qualities than control participants. Higher pain intensity was associated with female gender (ρ2 = 16%), anxiety/depression symptoms (ρ2 = 10%), and lower household income (ρ2 = 19%). It was also associated with better communicative ability (ρ2 = 21%), spinothalamic (sharp/temperature) sensory abnormalities (ρ2 = 33%), and a greater degree of prematurity (ρ2 = 17%). This study highlights similarity of chronic pain associations in people with cerebral palsy with patterns seen in other populations with chronic pain. Spinothalamic sensory abnormalities suggest central pain mechanisms.

5.
Dev Med Child Neurol ; 60(10): 976-986, 2018 10.
Article in English | MEDLINE | ID: mdl-29542813

ABSTRACT

To increase the efficiency and effectiveness of clinical research studies, cerebral palsy (CP) specific Common Data Elements (CDEs) were developed through a partnership between the National Institute of Neurological Disorders and Stroke (NINDS) and the American Academy of Cerebral Palsy and Developmental Medicine (AACPDM). International experts reviewed existing NINDS CDEs and tools used in studies of children and young people with CP. CDEs were compiled, subjected to internal review, and posted online for external public comment in September 2016. Guided by the International Classification of Functioning, Disability and Health framework, CDEs were categorized into six domains: (1) participant characteristics; (2) health, growth, and genetics; (3) neuroimaging; (4) neuromotor skills and functional assessments; (5) neurocognitive, social, and emotional assessments; and (6) engagement and quality of life. Version 1.0 of the NINDS/AACPDM CDEs for CP is publicly available on the NINDS CDE and AACPDM websites. Global use of CDEs for CP will standardize data collection, improve data quality, and facilitate comparisons across studies. Ongoing collaboration with international colleagues, industry, and people with CP and their families will provide meaningful feedback and updates as additional evidence is obtained. These CDEs are recommended for NINDS-funded research for CP. WHAT THIS PAPER ADDS: This is the first comprehensive Common Data Elements (CDEs) for children and young people with CP for clinical research. The CDEs for children and young people with CP include common definitions, the standardization of case report forms, and measures. The CDE guides the standardization for data collection and outcome evaluation in all types of studies with children and young people with CP. The CDE ultimately improves data quality and data sharing.


Subject(s)
Biomedical Research/standards , Cerebral Palsy , Common Data Elements/standards , Guidelines as Topic/standards , National Institute of Neurological Disorders and Stroke (U.S.)/standards , Societies, Medical/standards , Humans , United States
6.
Genet Med ; 20(1): 14-23, 2018 01.
Article in English | MEDLINE | ID: mdl-28640243

ABSTRACT

PurposeWith improved medical care, some individuals with holoprosencephaly (HPE) are surviving into adulthood. We investigated the clinical manifestations of adolescents and adults with HPE and explored the underlying molecular causes.MethodsParticipants included 20 subjects 15 years of age and older. Clinical assessments included dysmorphology exams, cognitive testing, swallowing studies, ophthalmic examination, and brain magnetic resonance imaging. Genetic testing included chromosomal microarray, Sanger sequencing for SHH, ZIC2, SIX3, and TGIF, and whole-exome sequencing (WES) of 10 trios.ResultsSemilobar HPE was the most common subtype of HPE, seen in 50% of the participants. Neurodevelopmental disabilities were found to correlate with HPE subtype. Factors associated with long-term survival included HPE subtype not alobar, female gender, and nontypical facial features. Four participants had de novo pathogenic variants in ZIC2. WES analysis of 11 participants did not reveal plausible candidate genes, suggesting complex inheritance in these cases. Indeed, in two probands there was a history of uncontrolled maternal type 1 diabetes.ConclusionIndividuals with various HPE subtypes can survive into adulthood and the neurodevelopmental outcomes are variable. Based on the facial characteristics and molecular evaluations, we suggest that classic genetic causes of HPE may play a smaller role in this cohort.


Subject(s)
Genetic Association Studies , Genetic Predisposition to Disease , Holoprosencephaly/diagnosis , Holoprosencephaly/genetics , Adolescent , Adult , Facies , Female , Genetic Testing , Humans , Magnetic Resonance Imaging , Male , Neuropsychological Tests , Phenotype , Registries , Young Adult
8.
J Pediatr ; 164(5): 1181-1188.e8, 2014 May.
Article in English | MEDLINE | ID: mdl-24607242

ABSTRACT

OBJECTIVE: To characterize the population pharmacokinetics (PK) of oral baclofen and assess impact of patient-specific covariates in children with cerebral palsy (CP) in order to support its clinical use. SUBJECTS DESIGN: Children (2-17 years of age) with CP received a dose of titrated oral baclofen from 2.5 mg 3 times a day to a maximum tolerated dose of up to 20 mg 4 times a day. PK sampling followed titration of 10-12 weeks. Serial R- and S-baclofen plasma concentrations were measured for up to 16 hours in 49 subjects. Population PK modeling was performed using NONMEM 7.1 (ICON PLC; Ellicott City, Maryland). RESULTS: R- and S-baclofen showed identical concentration-time profiles. Both baclofen enantiomers exhibited linear and dose/kg-proportional PK, and no sex differences were observed. Average baclofen terminal half-life was 4.5 hours. A 2-compartment PK model with linear elimination and transit absorption steps adequately described concentration-time profiles of both baclofen enantiomers. The mean population estimate of apparent clearance/F was 0.273 L/h/kg with 33.4% inter-individual variability (IIV), and the apparent volume of distribution (Vss/F) was 1.16 L/kg with 43.9% IIV. Delayed absorption was expressed by a mean transit time of 0.389 hours with 83.7% IIV. Body weight, a possible genetic factor, and age were determinants of apparent clearance in these children. CONCLUSION: The PK of oral baclofen exhibited dose-proportionality and were adequately described by a 2-compartment model. Our population PK findings suggest that baclofen dosage can be based on body weight (2 mg/kg per day) and the current baclofen dose escalation strategy is appropriate in the treatment of children with CP older than 2 years of age.


Subject(s)
Baclofen/pharmacokinetics , Cerebral Palsy/drug therapy , Muscle Relaxants, Central/pharmacokinetics , Absorption , Administration, Oral , Adolescent , Baclofen/blood , Baclofen/therapeutic use , Body Weight , Cerebral Palsy/blood , Child , Child, Preschool , Dose-Response Relationship, Drug , Drug Administration Schedule , Female , Half-Life , Humans , Male , Metabolic Clearance Rate , Models, Statistical , Multivariate Analysis , Muscle Relaxants, Central/blood , Muscle Relaxants, Central/therapeutic use
10.
Neuroimage ; 54(3): 1854-61, 2011 Feb 01.
Article in English | MEDLINE | ID: mdl-20920589

ABSTRACT

We have developed a new method to provide a comprehensive quantitative analysis of brain anatomy in cerebral palsy patients, which makes use of two techniques: diffusion tensor imaging and automated 3D whole brain segmentation based on our brain atlas and a nonlinear normalization technique (large-deformation diffeomorphic metric mapping). This method was applied to 13 patients and normal controls. The reliability of the automated segmentation revealed close agreement with the manual segmentation. We illustrate some potential applications for individual characterization and group comparison. This technique also provides a framework for determining the impact of various neuroanatomic features on brain functions.


Subject(s)
Atlases as Topic , Brain/pathology , Cerebral Palsy/pathology , Magnetic Resonance Imaging/methods , Brain Mapping/methods , Child , Child, Preschool , Data Interpretation, Statistical , Female , Humans , Image Processing, Computer-Assisted , Male , Nonlinear Dynamics , Observer Variation
11.
Neuroimage ; 52(2): 415-28, 2010 Aug 15.
Article in English | MEDLINE | ID: mdl-20420929

ABSTRACT

Quantification of normal brain maturation is a crucial step in understanding developmental abnormalities in brain anatomy and function. The aim of this study was to develop atlas-based tools for time-dependent quantitative image analysis, and to characterize the anatomical changes that occur from 2years of age to adulthood. We used large deformation diffeomorphic metric mapping to register diffusion tensor images of normal participants into the common coordinates and used a pre-segmented atlas to segment the entire brain into 176 structures. Both voxel- and atlas-based analyses reported a structure that showed distinctive changes in terms of its volume and diffusivity measures. In the white matter, fractional anisotropy (FA) linearly increased with age in logarithmic scale, while diffusivity indices, such as apparent diffusion coefficient (ADC), and axial and radial diffusivity, decreased at a different rate in several regions. The average, variability, and the time course of each measured parameter are incorporated into the atlas, which can be used for automated detection of developmental abnormalities. As a demonstration of future application studies, the brainstem anatomy of cerebral palsy patients was evaluated and the altered anatomy was delineated.


Subject(s)
Atlases as Topic , Automation , Brain/anatomy & histology , Brain/growth & development , Diffusion Tensor Imaging/methods , Image Processing, Computer-Assisted/methods , Adolescent , Adult , Anisotropy , Brain/pathology , Child , Child, Preschool , Diagnosis, Computer-Assisted/methods , Diffusion , Female , Humans , Linear Models , Male , Nerve Fibers, Myelinated/pathology , Organ Size , Time Factors , Young Adult
12.
Am J Med Genet C Semin Med Genet ; 154C(1): 183-90, 2010 Feb 15.
Article in English | MEDLINE | ID: mdl-20104615

ABSTRACT

Holoprosencephaly (HPE) is the most common malformation of the embryonic forebrain in humans. Although HPE occurs along a continuous spectrum, it has been categorized into four types from most severe to least severe: alobar, semilobar, lobar, and middle interhemispheric (MIH) variant. Facial malformations are often associated with HPE and usually correlate with the severity of brain malformation. With the most severely affected newborns, there is a high mortality rate in the first month of life, however, with milder forms of HPE, the majority survive beyond infancy. The Carter Centers for Brain Research in Holoprosencephaly and Related Malformations have enrolled 182 living children in a prospective research study. Based on previously published reports using this database, reports from other investigators, as well as our experience and personal observations, the range of developmental, neurological, and medical problems found in children with HPE is described in this article. Virtually all children with HPE have some developmental disability and the severity correlates with the severity of the brain malformation on neuroimaging. Common medical problems include hydrocephalus, seizures, motor impairment, oromotor dysfunction with risk of poor nutrition and aspiration, chronic lung disease, gastroesophageal reflux, constipation, hypothalamic dysfunction with disturbed sleep-wake cycles and temperature dysregulation, as well as endocrine dysfunction. Diabetes insipidus in particular is found in about 70% of children with classic HPE. Recommendations for management of these problems are given based on experiences of the authors and familiarity with the literature.


Subject(s)
Holoprosencephaly/therapy , Caregivers/education , Child , Developmental Disabilities/etiology , Developmental Disabilities/therapy , Diabetes Insipidus/etiology , Diabetes Insipidus/therapy , Holoprosencephaly/complications , Holoprosencephaly/mortality , Humans , Hydrocephalus/etiology , Hydrocephalus/therapy , Life Support Systems , Seizures/etiology , Seizures/therapy
13.
Am J Med Genet C Semin Med Genet ; 154C(1): 197-201, 2010 Feb 15.
Article in English | MEDLINE | ID: mdl-20104617

ABSTRACT

This article describes the experiences and perceived needs of a small cohort of parents of children with holoprosencephaly (HPE). The factors that are important to the lives of children vary across families and stages of development. As children living with HPE grow and change, parents adapt their goals and expectations to reflect their child's now and future state. Relevant literature is integrated within the discussion to support recommendations for care.


Subject(s)
Holoprosencephaly/psychology , Holoprosencephaly/therapy , Parent-Child Relations , Parents , Adult , Child , Emotions/physiology , Health Planning Guidelines , Humans , Perception/physiology , Quality of Life
14.
J Med Genet ; 47(8): 513-24, 2010 Aug.
Article in English | MEDLINE | ID: mdl-19955556

ABSTRACT

BACKGROUND: Holoprosencephaly (HPE), the most common malformation of the human forebrain, may be due to mutations in genes associated with non-syndromic HPE. Mutations in ZIC2, located on chromosome 13q32, are a common cause of non-syndromic, non-chromosomal HPE. OBJECTIVE: To characterise genetic and clinical findings in patients with ZIC2 mutations. METHODS: Through the National Institutes of Health and collaborating centres, DNA from approximately 1200 individuals with HPE spectrum disorders was analysed for sequence variations in ZIC2. Clinical details were examined and all other known cases of mutations in ZIC2 were included through a literature search. RESULTS: By direct sequencing of DNA samples of an unselected group of unrelated patients with HPE in our NIH laboratory, ZIC2 mutations were found in 8.4% (49/582) of probands. A total of 157 individuals from 119 unrelated kindreds are described, including 141 patients with intragenic sequence determined mutations in ZIC2. Only 39/157 patients have previously been clinically described. Unlike HPE due to mutations in other genes, most mutations occur de novo and the distribution of HPE types differs significantly from that of non-ZIC2 related HPE. Evidence is presented for the presence of a novel facial phenotype which includes bitemporal narrowing, upslanting palpebral fissures, a short nose with anteverted nares, a broad and well demarcated philtrum, and large ears. CONCLUSIONS: HPE due to ZIC2 mutations is distinct from that due to mutations in other genes. This may shed light on the mechanisms involved in formation of the forebrain and face and will help direct genetic counselling and diagnostic strategies.


Subject(s)
Holoprosencephaly/genetics , Holoprosencephaly/pathology , Mutation/genetics , Nuclear Proteins/genetics , Transcription Factors/genetics , Female , Genotype , Holoprosencephaly/classification , Holoprosencephaly/epidemiology , Humans , Inheritance Patterns/genetics , Magnetic Resonance Imaging , Male , Phenotype , Prevalence
15.
Dev Med Child Neurol ; 51(9): 697-704, 2009 Sep.
Article in English | MEDLINE | ID: mdl-19416315

ABSTRACT

AIM: Cerebral palsy (CP) is frequently linked to white matter injury in children born preterm. Diffusion tensor imaging (DTI) is a powerful technique providing precise identification of white matter microstructure. We investigated the relationship between DTI-observed thalamocortical (posterior thalamic radiation) injury, motor (corticospinal tract) injury, and sensorimotor function. METHOD: Twenty-eight children born preterm (16 males, 12 females; mean age 5y 10mo, SD 2y 6mo, range 16mo-13y; mean gestational age at birth 28wks, SD 2.7wks, range 23-34wks) were included in this case-control study. Twenty-one children had spastic diplegia, four had spastic quadriplegia, two had hemiplegia, and one had ataxic/hypotonic CP; 15 of the participants walked independently. Normative comparison data were obtained from 35 healthy age-matched children born at term (19 males, 16 females; mean age 5y 9mo, SD 4y 4mo, range 15mo-15y). Two-dimensional DTI color maps were created to evaluate 26 central white matter tracts, which were graded by a neuroradiologist masked to clinical status. Quantitative measures of touch, proprioception, strength (dynamometer), and spasticity (modified Ashworth scale) were obtained from a subset of participants. RESULTS: All 28 participants with CP had periventricular white-matter injury on magnetic resonance imaging. Using DTI color maps, there was more severe injury in the posterior thalamic radiation pathways than in the descending corticospinal tracts. Posterior thalamic radiation injury correlated with reduced contralateral touch threshold, proprioception, and motor severity, whereas corticospinal tract injury did not correlate with motor or sensory outcome measures. INTERPRETATION: These findings extend previous research demonstrating that CP in preterm children reflects disruption of thalamocortical connections as well as descending corticospinal pathways.


Subject(s)
Cerebral Palsy/pathology , Cerebral Palsy/physiopathology , Leukomalacia, Periventricular/pathology , Motor Skills Disorders/pathology , Pyramidal Tracts/pathology , Sensation Disorders/pathology , Adolescent , Case-Control Studies , Cerebral Palsy/complications , Child , Child, Preschool , Cohort Studies , Diffusion Magnetic Resonance Imaging , Female , Humans , Infant , Infant, Newborn , Infant, Premature , Leukomalacia, Periventricular/complications , Leukomalacia, Periventricular/physiopathology , Male , Motor Skills Disorders/etiology , Motor Skills Disorders/physiopathology , Pyramidal Tracts/physiopathology , Sensation Disorders/etiology , Sensation Disorders/physiopathology , Somatosensory Cortex/pathology , Somatosensory Cortex/physiopathology
16.
Pediatr Neurol ; 35(6): 375-81, 2006 Dec.
Article in English | MEDLINE | ID: mdl-17138005

ABSTRACT

Selecting and evaluating appropriate treatments for children with cerebral palsy has been challenging. One difficulty is in the ability to quantify the presence and importance of coexisting motor signs. This study presents quantitative measures developed to assess spasticity and dystonia. Children diagnosed with extrapyramidal or spastic cerebral palsy and matched control children were studied. Spasticity was measured as the slope of the force-velocity relationship from a test where we measured the forces required to passively extend the elbow at different velocities. Dystonia was assessed by measuring "overflow" movements of arm during active movement of the other arm. Measures of dystonia and spasticity did not correlate with one another, but did correlate with their respective clinical measurement tools, the Modified Ashworth scale and the Barry-Albright Dystonia scale. Most children had a combination of both spasticity and dystonia, despite diagnosis. Our measures also related to different aspects of reaching: children with increased dystonia made more curved paths, and children with increased spasticity hit higher peak velocities. These measurements allow us to distinguish between different motor disorders and the degree to which each contributes to reaching performance. Use of quantitative measures should improve selection and evaluation of treatments for childhood motor disorders.


Subject(s)
Cerebral Palsy/complications , Dystonia/diagnosis , Muscle Spasticity/diagnosis , Neurologic Examination/methods , Adolescent , Arm , Basal Ganglia Diseases/diagnosis , Basal Ganglia Diseases/etiology , Basal Ganglia Diseases/physiopathology , Cerebral Palsy/physiopathology , Child , Dystonia/etiology , Dystonia/physiopathology , Female , Humans , Male , Movement , Muscle Spasticity/etiology , Muscle Spasticity/physiopathology , Severity of Illness Index , Volition
17.
Pediatr Neurol ; 35(6): 387-94, 2006 Dec.
Article in English | MEDLINE | ID: mdl-17138007

ABSTRACT

Converging information on medical issues, motor ability, and cognitive outcomes is essential when addressing long-term clinical management in children with holoprosencephaly. This study considered whether adding more informative structural indices to classic holoprosencephaly categories would increase prediction of cognitive outcomes. Forty-two children with holoprosencephaly were examined to determine the association of deep gray nuclei abnormalities with cognitive abilities and the effect of motor skill deficits on cognitive performance. Additionally, a cognitive profile was described using the Carter Neurocognitive Assessment, an experimental diagnostic instrument designed specifically for young children with severe neurodevelopmental dysfunction. Findings indicated that nonseparation of the deep gray nuclei was significantly associated with the cognitive construct of vocal communication, but not with the cognitive constructs of social awareness, visual attention, or auditory comprehension. Importantly, motor skill deficits did not significantly affect performance on the Carter Neurocognitive Assessment. This study is the first investigation to provide a descriptive overview of specific cognitive skills in this group of children. The results also strongly suggest that this feature of the brain's structure does not predict all aspects of neurodevelopmental function. These findings contribute a critical component to the growing body of knowledge regarding the medical and clinical outcomes of children with holoprosencephaly.


Subject(s)
Brain/abnormalities , Cognition Disorders/pathology , Holoprosencephaly/pathology , Adolescent , Age Factors , Child , Child, Preschool , Cognition , Corpus Striatum/abnormalities , Epilepsy/pathology , Female , Humans , Hypothalamus/abnormalities , Infant , Male , Motor Skills Disorders/pathology , Neuropsychological Tests , Predictive Value of Tests , Severity of Illness Index , Sex Factors , Thalamic Nuclei/abnormalities
18.
Brain Dev ; 28(7): 413-9, 2006 Aug.
Article in English | MEDLINE | ID: mdl-16503393

ABSTRACT

The objective of this study is to better understand the relationship between neuroradiologic and clinical characteristics in holoprosencephaly (HPE) using the multivariate analysis called factor analysis. HPE is a brain malformation characterized by incomplete cleavage of the cerebral hemispheres and deep gray structures. We performed evaluations on 89 children with HPE that included their history, developmental assessment, and physical examination. Ten clinical variables included in factor analysis were the grade of spasticity, dystonia, choreoathetosis, hypotonia, mobility, upper extremity/hand function, expressive language, feeding/swallowing difficulty, endocrinopathies, and temperature dysregulation. Five neuroimaging variables graded by pediatric neuroradiologists were the grade of HPE (from least to most severe: lobar, semilobar, and alobar) and the degree of non-separation of caudate, lentiform, thalamic, and hypothalamic nuclei. Factor analysis using principle component extraction and varimax rotation was utilized. Four significant factors were identified: (1) neuroimaging/developmental factor, (2) motor factor, (3) hypothalamic/oromotor factor, and (4) hypotonia factor. These four factors accounted for 65.2% of the variance. In this factor analysis of HPE patients, we were able to reduce the large number of clinical and radiological variables into four factors. These factors and the constructs underlying them provide structure to the data and provide key parameters for future studies involving neurodevelopmental outcomes in HPE.


Subject(s)
Brain , Factor Analysis, Statistical , Holoprosencephaly , Brain/growth & development , Brain/pathology , Child, Preschool , Evaluation Studies as Topic , Female , Follow-Up Studies , Holoprosencephaly/diagnostic imaging , Holoprosencephaly/pathology , Holoprosencephaly/physiopathology , Humans , Magnetic Resonance Imaging/methods , Male , Neurologic Examination/methods , Retrospective Studies , Time Factors , Tomography, X-Ray Computed/methods
19.
Am J Med Genet A ; 128A(2): 114-9, 2004 Jul 15.
Article in English | MEDLINE | ID: mdl-15213999

ABSTRACT

Holoprosencephaly (HPE) is a brain malformation resulting from a primary defect in development of the basal forebrain during early gestation. Prenatal genetic and environmental factors and birth outcomes were described in a population of 104 children with holoprosencephaly referred to three clinical centers from 1998 through 2002. The mean child age was 4 years. Of cases karyotyped, 9% presented with a chromosomal abnormality. This study of living children with holoprosencephaly, the majority of whom are cytogenetically normal, provides new information on the subsample of children with a less severe phenotype. Most children were born at term; about 51% were microcephalic at birth. Consistent with previous research, the association between HPE and maternal history of diabetes merits further investigation. Several findings have important implications for future research. Only 22% of the children in this study sample were diagnosed with holoprosencephaly prenatally. The vast majority of children (72%) were diagnosed with HPE between birth and 1 year of age. Also, 19% of the cases referred to the Carter Centers with HPE were not confirmed on scan review. When possible, future population-based epidemiological studies should emphasize mechanisms that identify children with HPE outside of the newborn period and confirm the diagnosis by review of MRI or high quality CT brain scan.


Subject(s)
Holoprosencephaly/epidemiology , Holoprosencephaly/genetics , Adolescent , Brain/metabolism , Child , Child, Preschool , Chromosome Aberrations , Environment , Female , Gestational Age , Humans , Infant , Infant, Newborn , Karyotyping , Male , Microcephaly/epidemiology , Phenotype , Pregnancy , Pregnancy Outcome , Prenatal Care , Prenatal Diagnosis , Prosencephalon/metabolism , Retrospective Studies , Risk Factors , Time Factors , Ultrasonography, Prenatal
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