1.
J Med Chem
; 22(9): 1074-9, 1979 Sep.
Article
in English
| MEDLINE
| ID: mdl-490552
ABSTRACT
The synthesis and antiinflammatory activity of 2-amino-3-benzoylphenylacetic acid are described. This compound was postulated to be an active metabolite of 7-benzoylindoline in order to explain the unexpected antiinflammatory activity of the latter compound. Metabolism studies on 14C-labeled 7-benzoylindoline did not confirm this hypothesis. Nevertheless, 2-amino-3-benzoylphenylacetic acid, its ethyl ester, and the sodium salt show potent antiinflammatory activity in pharmacological models.
Subject(s)
Anti-Inflammatory Agents/chemical synthesis , Phenylacetates/chemical synthesis , Animals , Arthritis, Experimental/drug therapy , Benzophenones/chemical synthesis , Benzophenones/metabolism , Benzophenones/pharmacology , Benzophenones/therapeutic use , Biotransformation , Female , In Vitro Techniques , Male , Phenylacetates/metabolism , Phenylacetates/pharmacology , Phenylacetates/therapeutic use , Pleural Effusion/drug therapy , Rats
2.
J Med Chem
; 17(5): 544-7, 1974 May.
Article
in English
| MEDLINE
| ID: mdl-4830260
