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1.
Bone Joint J ; 99-B(10): 1389-1398, 2017 Oct.
Article in English | MEDLINE | ID: mdl-28963162

ABSTRACT

AIMS: This study assessed the association of classes of body mass index in kg/m2 (classified as normal weight 18.5 kg/m2 to 24.9 kg/m2, overweight 25.0 kg/m2 to 29.9 kg/m2, and obese ≥ 30.0 kg/m2) with short-term complications and functional outcomes three to six years post-operatively for closed ankle fractures. PATIENTS AND METHODS: We performed a historical cohort study with chart review of 1011 patients who were treated for ankle fractures by open reduction and internal fixation in two hospitals, with a follow-up postal survey of 959 of the patients using three functional outcome scores. RESULTS: Obese patients had more severe overall complications and higher odds of any complication than the normal weight group, with adjusted odds ratio 1.67 (95% confidence interval (CI) 1.08 to 2.59; p = 0.021) and 1.71 (95% CI 1.10 to 2.65; p = 0.016), respectively. In total 479 patients (54.6%) responded to the questionnaire. Obese patients had worse scores on the Olerud and Molander Ankle Score (p < 0.001), Self-Reported Foot and Ankle Questionnaire (p = 0.003) and Lower Extremity Functional Scale (p = 0.01) than those with normal weight. In contrast, overweight patients did not have worse functional scores than those with normal weight. CONCLUSION: Obese patients had more complications, more severe complications, and worse functional outcomes three to six years after ankle surgery compared with those with normal weight. Cite this article: Bone Joint J 2017;99-B:1389-98.


Subject(s)
Ankle Fractures/surgery , Ankle Joint/physiopathology , Body Mass Index , Bone Screws , Fracture Fixation, Internal/adverse effects , Postoperative Complications/etiology , Recovery of Function , Adolescent , Adult , Aged , Aged, 80 and over , Ankle Fractures/diagnosis , Ankle Fractures/physiopathology , Ankle Joint/diagnostic imaging , Ankle Joint/surgery , Female , Follow-Up Studies , Humans , Male , Middle Aged , Retrospective Studies , Time Factors , Treatment Outcome , Young Adult
2.
Injury ; 48(7): 1662-1669, 2017 Jul.
Article in English | MEDLINE | ID: mdl-28392074

ABSTRACT

AIMS: To evaluate the associations of timing of surgery with postoperative length of stay (LOS), complications, and functional outcomes 3-6 years after open reduction and internal fixation (ORIF) in closed ankle fractures. PATIENTS AND METHODS: Historical cohort study by chart review of 1011 patients for postoperative LOS and complications; 959 individuals were invited to participate in a postal survey with functional outcomes questionnaires. Complications were classified as perioperative, early, or late. The associations with time from trauma to surgery (<8h, 8h to 6days, >6days) were assessed with (1) postoperative LOS using multivariable random-effects negative binomial regression, (2) complications using multivariable binary and multinomial logistic regression, and (3) three different functional outcomes using multivariable linear regression. RESULTS: The mean patient age was 51.4 (range 18-94) years, 556 (55%) were female, and 567 individuals (59%) responded to the questionnaire. There were no statistically significant associations between time to surgery and either postoperative LOS or complications after adjusting for several patient and fracture characteristics. Patients operated on >6days after the trauma had significantly worse scores on the Olerud and Molander Ankle Score (OMAS) (p=0.039) and somewhat worse, but non-significant, scores on the Lower Extremity Functional Scale (LEFS; p=0.573) and the Self-Reported Foot and Ankle Score (SEFAS) scale (p=0.161) than those operated on <8h after trauma. CONCLUSION: In ankle-fracture surgery, there was no apparent association between timing of surgery and postoperative LOS or complications. A delay of surgery for 8h to 6days resulted in similar functional outcomes after 3-6 years suggesting there may be a safe window of time for surgery of up to 6days after trauma that can be used to plan and perform the final ORIF.


Subject(s)
Ankle Fractures/physiopathology , Fracture Fixation, Internal , Fractures, Closed/physiopathology , Postoperative Complications/physiopathology , Time-to-Treatment/statistics & numerical data , Adolescent , Adult , Aged , Aged, 80 and over , Ankle Fractures/rehabilitation , Ankle Fractures/surgery , Female , Follow-Up Studies , Fractures, Closed/rehabilitation , Fractures, Closed/surgery , Health Care Surveys , Humans , Length of Stay/statistics & numerical data , Male , Middle Aged , Norway , Postoperative Period , Recovery of Function , Treatment Outcome , Young Adult
3.
Health Qual Life Outcomes ; 15(1): 51, 2017 Mar 14.
Article in English | MEDLINE | ID: mdl-28292292

ABSTRACT

BACKGROUND: The interpretation of the SF-36 in Norwegian populations largely uses normative data from 1996. This study presents data for the general population from 2002-2003 which has been used for comparative purposes but has not been assessed for measurement properties. METHODS: As part of the Norwegian Level of Living Survey 2002-2003, a postal survey was conducted comprising 9,164 members of the general population aged 16 years and over representative for Norway who received the Norwegian SF-36 version 1.2. The SF-36 was assessed against widely applied criteria including data completeness and assumptions relating to the construction and scoring of multi-item scales. Normative data are given for the eight SF-36 scales and the two summary scales (PCS, MCS) for eight age groups and gender. RESULTS: There were 5,396 (58.9%) respondents. Item levels of missing data ranged from 0.6 to 3.0% with scale scores computable for 97.5 to 99.8% of respondents. All item-total correlations were above 0.4 and were of a similar level with the exceptions of the easiest and most difficult physical function items and two general health items. Cronbach's alpha exceeded 0.8 for all scales. Under 5% of respondents scored at the floor for five scales. Role-physical had the highest floor effect (14.6%) and together with role-emotional had the highest ceiling effects (66.3-76.8%). With three exceptions for the eight age groups, females had lower scores than males across the eight health scales. The two youngest age groups (<30 years) had the highest scores for physical aspects of health; physical function, role-physical, bodily pain and general health. The age groups 40-49 and 60-69 years had the highest scores for role-emotional and mental health respectively. CONCLUSIONS: This SF-36 data meet necessary criteria for applications of normative data. The data is more recent, has more respondents including older people than the original Norwegian normative data from 1996, and can help the interpretation of SF-36 scores in applications that include clinical and health services research.


Subject(s)
Health Status Indicators , Health Status , Quality of Life , Surveys and Questionnaires/standards , Adult , Aged , Female , Humans , Male , Mental Health , Middle Aged , Norway , Psychometrics , Research Design , Young Adult
4.
Injury ; 47(8): 1783-8, 2016 Aug.
Article in English | MEDLINE | ID: mdl-27262772

ABSTRACT

BACKGROUND: Implant removal in ankle fractures treated by open reduction and fixation is often based on diffuse complaints. This study determined the incidence of implant removal and identified risk factors for two principal causes for removal: complaints and surgical site infection (SSI). METHODS: Retrospective cohort study involving 997 patients operated on 2009-2011 with follow-up through to 2013. The incidence of implant removal was analysed using competing risk analysis. Risk factors for implant removal were assessed using cause-specific hazard ratios (HRs) from a Cox regression analysis. RESULTS: The mean age at surgery was 51.6 years, 550 (55%) of the patients were female, and 170 patients (17%) had implant removal: 144 due to complaints and 26 due to infection. Multivariable HRs for implant removal due to complaints were 0.70 for male sex (p=0.047), 0.79 for each 10-year increase in age (p<0.001), 0.70 for treatment with a syndesmosis screw (p=0.038), and 1.09 for each 15-min increase in operation duration (p=0.007). HRs for hardware removal due to infection were 1.42 for each 10-year increase in age (p=0.006) and 3.15 for current smoking (p=0.005). CONCLUSION: In total 17% of patients had implant removal after open reduction and fixation; the majority because of subjective complaints. The risk factors for implant removal were different for removal due to complaints than for those removed due to infection. This information may be used to inform patients about the risk and risk factors for future implant removal.


Subject(s)
Ankle Fractures/surgery , Device Removal/methods , Fracture Fixation, Internal/instrumentation , Joint Instability/surgery , Pain, Postoperative/epidemiology , Surgical Wound Infection/epidemiology , Ankle Fractures/physiopathology , Bone Plates/adverse effects , Bone Screws/adverse effects , Female , Fracture Fixation, Internal/adverse effects , Humans , Incidence , Joint Instability/physiopathology , Male , Middle Aged , Norway/epidemiology , Pain, Postoperative/surgery , Retrospective Studies , Risk Assessment , Risk Factors , Surgical Wound Infection/surgery , Treatment Outcome
5.
Scand J Urol ; 50(3): 220-7, 2016 Jun.
Article in English | MEDLINE | ID: mdl-26901820

ABSTRACT

Objective Finasteride 5 mg is a drug used to treat prostate hyperplasia. Little is known about its pattern of usage. This cross-national analysis of individual-level data from Denmark, Finland, Norway and Sweden was undertaken to appraise its usage and describe cross-national differences. Materials and methods Individual-level data from nationwide prescription registers in Denmark (1995-2009), Finland (1997-2010), Norway (2004-2009) and Sweden (July 2005-2011) were used to examine cross-national finasteride utilization patterns in the adult male population (≥15 years). The study presents period prevalences, incidence rates, waiting time distributions and Lorenz curves. Results During the study period, 295,620 men had at least one prescription redemption of finasteride 5 mg, and there were approximately 3 million dispensing events of finasteride prescriptions in the four Nordic countries. Different patterns of finasteride use were observed among the four Nordic countries. The period prevalence was markedly higher in Finland and Sweden than in Denmark and Norway. In 2009, period prevalences were 18.2/1000 males in Finland and 12.0/1000 males in Sweden compared to 6.7/1000 males in Norway and 4.9/1000 males in Denmark. Incidence rates of finasteride use for Finland, Norway and Sweden were about three times that for Denmark in 2008-2009. Long-term use of finasteride was found in all four Nordic countries with a high ratio between prevalent and incident users. Conclusion Despite resemblances regarding political systems and healthcare services in the Nordic countries, differences in finasteride utilization were found across Denmark, Finland, Norway and Sweden.


Subject(s)
5-alpha Reductase Inhibitors/therapeutic use , Finasteride/therapeutic use , Practice Patterns, Physicians' , Prostatic Hyperplasia/drug therapy , Aged , Drug Utilization/statistics & numerical data , Humans , Male , Scandinavian and Nordic Countries
6.
Eur J Clin Microbiol Infect Dis ; 34(9): 1833-7, 2015 Sep.
Article in English | MEDLINE | ID: mdl-26076750

ABSTRACT

Staphylococcus aureus (S. aureus) is the most common cause of bone and joint infections. However, limited information is available on the distribution of S. aureus geno- and phenotypes causing orthopaedic infections. The aim of this study was to identify the dominating types causing infections in orthopaedic patients, investigate if the characteristics of these types changed over time and examine if different types were more often associated with surgical site infection (SSI) than primary infection (non-SSI). All clinical S. aureus isolates collected from orthopaedic patients from 2000 through 2011 at Akershus University Hospital, Norway, were characterised by S. aureus protein A (spa) typing and tested for antibiotic resistance. A total of 548 patients with orthopaedic S. aureus infections were included, of which 326 (59 %) had SSI and 222 (41 %) had non-SSI. The median age was 62 years [range 2-97 years] and 54 % were male. Among the 242 unique spa types, t084 was the most common (7 %). Penicillin resistance was identified in 75 % of the isolates, whereas the resistances to the other antibiotics tested were <5 %. Three isolates (0.5 %) were resistant to methicillin. There was no significant difference in the distribution of geno- and phenotypes over time and there was no difference in types between SSI and non-SSI. In this large collection of S. aureus from orthopaedic patients, the S. aureus infections, regardless of origin, were heterogeneous, mainly resistant to penicillin, stable over time and consisted of similar types as previously found in both carrier and other patient populations.


Subject(s)
Bone Diseases, Infectious/microbiology , Joint Diseases/microbiology , Staphylococcal Infections/drug therapy , Staphylococcus aureus/isolation & purification , Surgical Wound Infection/microbiology , Adolescent , Adult , Aged , Aged, 80 and over , Anti-Bacterial Agents/therapeutic use , Bacterial Typing Techniques , Bone Diseases, Infectious/drug therapy , Child , Child, Preschool , Cohort Studies , Cross Infection/microbiology , Drug Resistance, Bacterial , Female , Humans , Joint Diseases/drug therapy , Male , Microbial Sensitivity Tests , Middle Aged , Orthopedic Procedures/adverse effects , Prospective Studies , Staphylococcal Infections/microbiology , Staphylococcal Protein A/genetics , Staphylococcus aureus/classification , Staphylococcus aureus/drug effects , Surgical Wound Infection/drug therapy , Young Adult
7.
Acta Anaesthesiol Scand ; 58(3): 329-36, 2014 Mar.
Article in English | MEDLINE | ID: mdl-24405518

ABSTRACT

BACKGROUND: To withhold and withdraw treatment are important and difficult decisions made in the intensive care unit (ICU). The aim of this study was to investigate the incidence of withholding or withdrawing treatment, characteristics of the patients, and how these decision processes were handled and documented in a general ICU from 2007 to 2009 in a university hospital in Norway. METHODS: Patient characteristics and outcomes of treatment were prospectively registered. We retrospectively reviewed the medical records for information on limitations in treatment. RESULTS: In total, 1287 patients were admitted to the ICU. The ICU mortality was 208 (16%), and the hospital mortality was 341 (26%). In total, 301 patients (23%) had treatment withheld or withdrawn. Medical and unscheduled surgical patients with limitations in treatment had higher Simplified Acute Physiology Score II (P < 0.001) and were older (P < 0.001) than those without limitations in treatment. The most common main reason for withdrawing treatment was poor prognosis. According to the medical records, the patient was involved in the decision-making regarding withdrawal of treatment in only 2% of the cases, and the patient's relatives were involved in the decision-making in 77% of the cases. In 12% of the cases, type of treatment withdrawn was not documented. CONCLUSION: Withholding or withdrawing treatment in the ICU was common. Medical and unscheduled surgical patients with limitations in treatment were older and more severely ill than patients without limitations. There is a potential for better documentation of the processes regarding withholding or withdrawing life-sustaining intensive care treatment.


Subject(s)
Critical Care/ethics , Intensive Care Units/ethics , Life Support Care/ethics , Resuscitation Orders/ethics , Withholding Treatment/ethics , Adult , Aged , Aged, 80 and over , Documentation , Female , Hospital Mortality , Hospitals, University , Humans , Male , Middle Aged , Norway , Referral and Consultation , Retrospective Studies , Treatment Outcome
8.
Acta Neurol Scand ; 124(6): 429-33, 2011 Dec.
Article in English | MEDLINE | ID: mdl-22017635

ABSTRACT

BACKGROUND: Few studies have assessed the influence of the organization of stroke care on long-term survival. AIMS OF THE STUDY: To compare survival over 12 years after stroke between subjects treated in an acute stroke unit (SU) and those treated in general medical wards (GMW). METHODS: In total, 550 subjects ≥60 years of age with acute stroke were prospectively allocated according to date of birth (day of the month) to treatment in a SU with relatively short length of stay or GMWs. We assessed survival through a link to the register of Statistics Norway. Groups were compared using Kaplan-Meier analysis on an intention-to-treat basis. RESULTS: Of the 550 eligible subjects, 271 were allocated to a SU and 279 to GMWs. There still was no difference in mortality over 12 years between the groups (P = 0.15, log-rank test) CONCLUSIONS: An acute SU offering early treatment and rehabilitation did not offer better long-term mortality after stroke in patients ≥60 years old than initial treatment in GMWs.


Subject(s)
Hospital Units/statistics & numerical data , Stroke/mortality , Stroke/therapy , Aged , Cohort Studies , Female , Humans , Kaplan-Meier Estimate , Male , Norway
9.
Am J Transplant ; 11(6): 1315-9, 2011 Jun.
Article in English | MEDLINE | ID: mdl-21486387

ABSTRACT

Reports on quality of life of kidney donors include small populations with variable response rates. The aim was to evaluate quality of life in kidney donors in a large cross-sectional study. Through the Norwegian Renal Registry we contacted all 1984 kidney donors in the period 1963-2007 with a response rate of 76%. All received the Short-Form-36 (SF-36) survey form and a questionnaire specifically designed for kidney donors. SF-36 scores for a subgroup (n = 1414) of kidney donors were not inferior to a general population sample, adjusted for age, gender and education. When asked to reconsider, a majority stated that they still would have consented to donate. Risk factors for having doubts were graft loss in the recipient (OR 3.1, p < 0.001), medical problems after donation (OR 3.7, p < 0.001), unrelated donor (OR 2.2, p = 0.01) and less than 12 years since donation (OR 1.8, p = 0.04). Older age at donation was associated with lower risk (OR 0.98, p = 0.03). Compared with other donors, those expressing doubts had inferior SF-36 scores. Norwegian kidney donors are mostly first-degree relatives. They are fully reimbursed and offered life-long follow-up. All inhabitants are provided universal healthcare. This should be considered when extrapolating these results to other countries.


Subject(s)
Kidney Transplantation , Living Donors , Quality of Life , Adult , Cross-Sectional Studies , Female , Humans , Male , Middle Aged , Norway , Registries
10.
Int J Tuberc Lung Dis ; 13(3): 400-6, 2009 Mar.
Article in English | MEDLINE | ID: mdl-19275804

ABSTRACT

OBJECTIVE: To assess the agreement of a self-completed diary to monitor respiratory symptoms in children aged 6-12 years with parental symptom reports and fluctuations in lung function. DESIGN: We created a text- and symbol-based questionnaire for daily completion by children at school. Using a screening questionnaire completed by the parents, we selected 101 children with lower respiratory symptoms in the last year or doctor-diagnosed asthma to complete the diary. We assessed the agreement with a parent-completed daily symptom diary and measurements of peak expiratory flow (PEF) over 5 weeks, estimating % agreement and the kappa statistic (kappa) for pairwise comparisons. RESULTS: Simple agreement between PEF variability, parent-reported and child-reported symptoms was moderate to high. Using kappa, agreement between children's and parents' reports of respiratory symptoms was only fair to moderate, and agreement with lung function measurements was poor for both parent- and child-reported symptoms. CONCLUSION: Agreement between children's and parents' reports on day-to-day respiratory symptoms was fair to moderate. The children's symptom diary agreed poorly with lung function measurements, but was neither worse nor better than the parent-completed diary.


Subject(s)
Medical Records , Respiratory Sounds/physiopathology , Child , Female , Health Status , Humans , Male , Observer Variation , Parents , Peak Expiratory Flow Rate , Respiratory Function Tests , Surveys and Questionnaires
11.
Acta Anaesthesiol Scand ; 52(9): 1265-72, 2008 Oct.
Article in English | MEDLINE | ID: mdl-18823467

ABSTRACT

BACKGROUND: Amino-terminal fragments of type-A and type-B natriuretic peptide prohormones (NT-proBNP, NT-proANP) are powerful prognostic markers in patients with cardiac disease, and NT-proBNP has been demonstrated to predict outcome in severe sepsis and septic shock. We assessed the prognostic value of NT-proBNP and NT-proANP in a consecutive series of mechanically ventilated intensive care patients and compared their prognostic merit. METHODS: Seventy unselected patients admitted to the intensive care unit (ICU) were included in the study 48 h after start of controlled mechanical ventilation. Venous blood was obtained on inclusion and assayed for NT-proBNP and NT-pro ANP. Univariate and multivariate logistic regression analysis was used to assess the association of NT-proBNP and NT-proANP levels with 30-day mortality. Established risk factors and possible confounders were used as covariates. Discrimination of different prognostic models was assessed calculating the area under the receiver-operating characteristics curve (ROC-AUC). RESULTS: NT-proBNP and NT-proANP levels were higher in non-survivors (n=25) than in 30-day survivors (n=45). Log NT-proBNP [odds ratio (OR) 2.34, 95% CI 1.17-4.66], and log NT-proANP (OR 2.44, 95% CI 1.12-5.30) were independently predictive of increased mortality. A prior diagnosis of chronic obstructive lung disease was predictive of decreased mortality (OR 0.29, 95% CI 0.08-1.00). The relative prognostic values, evaluated by the ROC-AUCs of NT-proBNP (AUC 0.74, 95% CI 0.61-0.86) and NT-proANP (AUC 0.73, 95% CI 0.61-0.86), were nearly identical. CONCLUSIONS: High NT-proANP and NT-proBNP levels associated with decreased short-term survival in unselected, mechanically ventilated ICU patients. NT-proANP performed equally well as a prognostic indicator as NT-proBNP, and may represent a clinically useful alternative to NT-proBNP.


Subject(s)
Atrial Natriuretic Factor/blood , Natriuretic Peptide, Brain/blood , Peptide Fragments/blood , Biomarkers , Calibration , Critical Illness/mortality , Female , Humans , Male , Middle Aged , Prognosis
12.
J Plast Reconstr Aesthet Surg ; 61(10): 1188-94, 2008 Oct.
Article in English | MEDLINE | ID: mdl-17604241

ABSTRACT

In a cross-sectional postal survey, we compared patient-reported outcomes in patients undergoing breast reconstruction with the deep inferior epigastric perforator (DIEP) flap or an expandable breast implant (EBI). We included 34 consecutive patients who had breast reconstruction with DIEP flap and 30 patients with EBI. Outcomes were assessed using the Short Form 36 (SF-36) quality of life questionnaire, two study-specific patient satisfaction questionnaires and a visual analogue scale (VAS) on cosmetic result. There were no significant differences in SF-36 subscale scores between the two groups. On the study-specific questionnaire, more patients in the DIEP group were satisfied with the appearance of their breast (P<0.0005) and reported an improved social relationship (P=0.02), and fewer patients were sad about their body image (P=0.01) after reconstruction than in the EBI group. On the other study-specific items, satisfaction was similar in the two groups. On all five VAS items, DIEP patients reported better cosmetic results than EBI patients. We conclude that patient satisfaction and cosmetic outcome were better after breast reconstruction with the DIEP flap compared with EBI, while there was no difference in health-related quality of life.


Subject(s)
Breast Implantation/methods , Breast Implants , Mammaplasty , Patient Satisfaction , Quality of Life , Surgical Flaps , Cross-Sectional Studies , Female , Humans , Mammaplasty/methods , Mammaplasty/psychology , Middle Aged
13.
J Neurol ; 254(10): 1376-83, 2007 Oct.
Article in English | MEDLINE | ID: mdl-17934885

ABSTRACT

CONTEXT: Numerous models have been presented for the prognosis in acute stroke; however they have been criticized for being difficult to use, and few have been validated in independent samples. OBJECTIVES: To develop simple risk score models for 1-year mortality in acute stroke in patients > 60 years old and validate the models. DESIGN: From a cohort of 2321 consecutive patients > 60 years of age with acute stroke in one hospital, we randomly selected 800 patients for chart review. Among 737 patients with validated acute stroke, we randomly split the sample into (1) a derivation (60%; n = 442) and (2) a validation sample (40%; n=295). We used logistic regression to develop three models with 2-4 covariates and a corresponding risk score from the derivation sample. The models were validated using area under the receiver operating curves. RESULTS: Three risk score models for 1-year mortality after stroke were developed using combinations of age, Canadian Neurological Scale score (CNSscore) (< or = 3.5 = 0, >3.5 = 1), Charlson comorbidity index and stroke type (ischemic = 0, hemorrhagic = 1). Both 2-variable (Age - 60 + (30*CNSscore)), 3-variable (Age - 60 + (30*CNSscore) + 4*Charlson)) and 4-variable (Age - 60 + (25*CNSscore) + (5*Charlson) + (18*Stroke type)) models reliably predicted the outcome with an area under the receiver operating curve ranging 0.71 to 0.72. CONCLUSIONS: Simple models incorporating two to four covariates reliably predicted 1-year mortality. Such models can be used to stratify prognosis in clinical practice, research or intervention trials.


Subject(s)
Proportional Hazards Models , Risk Factors , Stroke/mortality , Survival Analysis , Aged , Aged, 80 and over , Cohort Studies , Data Interpretation, Statistical , Female , Humans , Male , Middle Aged , Predictive Value of Tests , Random Allocation , Reproducibility of Results , Retrospective Studies , Severity of Illness Index , Stroke/epidemiology
14.
Osteoarthritis Cartilage ; 15(7): 837-43, 2007 Jul.
Article in English | MEDLINE | ID: mdl-17344069

ABSTRACT

OBJECTIVE: Little has been reported on changes in health status in patients with osteoarthritis (OA) while waiting for hip or knee replacement surgery. In this study we assessed (1) changes in self-reported pain, stiffness and physical function in patients with OA of the hip or knee, from the decision to undergo surgery to 14 days prior to surgery, and (2) the determinants of these changes. METHODS: Among 353 baseline respondents, 170 waited >30 days for surgery, completed the Western Ontario and McMaster Universities Arthritis Index (WOMAC) before surgery and were included in the analysis of changes; 120 with OA of the hip and 50 of the knee. We analyzed changes in WOMAC scores using the paired t test and determinants of the changes using multiple linear regression. RESULTS: Patients with OA of the hip did not change on any WOMAC scale before surgery. Knee patients deteriorated with time on the WOMAC stiffness and total scales, but not on the pain or physical function subscales. In both patient categories, higher baseline WOMAC scores were associated with smaller changes on all subscales and the total score, and female sex was associated with deterioration on the pain subscale. CONCLUSIONS: Patients with OA of the hip reported no change in pain, stiffness or physical function while waiting for joint replacement surgery, whereas patients with OA of the knee deteriorated on the stiffness and total scales of the WOMAC. This suggests a difference in patient selection, referral pattern or disease development between the patient categories.


Subject(s)
Arthroplasty, Replacement/methods , Osteoarthritis/physiopathology , Pain Measurement , Aged , Disease Progression , Female , Health Status Indicators , Humans , Male , Middle Aged
15.
J Intern Med ; 260(4): 332-42, 2006 Oct.
Article in English | MEDLINE | ID: mdl-16961670

ABSTRACT

OBJECTIVES: It is well known that pulmonary function is associated with all-cause and cardiovascular (CV) death. Less is known about the association between respiratory symptoms and mortality and whether such an association is independent of physical fitness. In this study, we assessed the association of breathlessness and productive cough with CV and all-cause mortality over 26 years. DESIGN: Prospective occupational cohort study. SETTING AND SUBJECTS: In 1972-75, 1999 apparently healthy men aged 40-59 years were recruited to the study from five companies in Oslo, Norway. At study entry clinical, physiological and biochemical parameters including respiratory symptoms, spirometry, and an objective assessment of physical fitness were measured in all subjects, of whom 1,623 had acceptable spirometry. The data was analysed using Cox proportional hazards analysis, adjusting for age, lung function, physical fitness, and other possible confounders, with mortality until 2000. RESULTS: After 26 years (range 25-27), 615 men (38%) had died, of whom 308 (50%) from CV deaths. In multivariable proportional hazards models, 'having phlegm winter mornings' [hazard ratio (HR) 1.30, P = 0.01], 'breathlessness when hurrying/walking uphill' (HR 1.43, P = 0.005) and combinations of the two symptoms remained significant predictors of all-cause mortality. None of six respiratory symptoms were significant predictors of CV mortality in multivariable models. CONCLUSIONS: Phlegm, breathlessness and combinations of them were associated with all-cause mortality, even after adjusting for physical fitness, known CV and other risk factors such as smoking, and lung function. The finding of an association also after adjustment for physical fitness is new. In contrast, none of the six respiratory symptoms individually or in combination were associated with CV mortality in multivariable analysis.


Subject(s)
Cardiovascular Diseases/mortality , Respiration Disorders/mortality , Adult , Cardiovascular Diseases/physiopathology , Cause of Death , Cough/mortality , Cough/physiopathology , Dyspnea/mortality , Dyspnea/physiopathology , Exercise/physiology , Humans , Male , Middle Aged , Norway/epidemiology , Occupational Diseases/mortality , Occupational Diseases/physiopathology , Physical Fitness/physiology , Prospective Studies , Respiration Disorders/physiopathology , Respiratory Function Tests/methods , Risk Factors , Smoking/mortality
16.
Acta Neurol Scand ; 112(1): 13-8, 2005 Jul.
Article in English | MEDLINE | ID: mdl-15932350

ABSTRACT

OBJECTIVES: To assess predictors of headache in patients who had sustained a head injury 22 years earlier. MATERIALS AND METHODS: A questionnaire about headache was sent to 361 subjects hospitalized for head injury in 1974-1975. RESULTS: A total of 249 patients (69%) responded to the questionnaire. The prevalence of headache >14 days a month last year was 11%. In multivariate logistic regression analysis female sex (OR = 3.4, 95% CI 1.2-9.6), severe headache 3 months after the head injury (OR = 10.6, 95% CI 2.6-43.5) and psychiatric disease (OR = 2.9, 95% CI 1.1-7.7) predicted chronic headache. There was no significant association between chronic headache and post-traumatic amnesia or other trauma-related variables. CONCLUSION: Female sex and headache 3 months after the head injury were the strongest predictors of long-term headache, while there was little association between long-term headache and trauma variables.


Subject(s)
Craniocerebral Trauma/epidemiology , Headache Disorders/epidemiology , Adult , Amnesia/epidemiology , Causality , Chronic Disease/epidemiology , Cohort Studies , Comorbidity , Female , Humans , Male , Middle Aged , Multivariate Analysis , Norway , Prevalence , Sex Factors , Surveys and Questionnaires , Time
17.
Complement Ther Med ; 13(1): 4-10, 2005 Mar.
Article in English | MEDLINE | ID: mdl-15907672

ABSTRACT

OBJECTIVES: To compare traditional Chinese acupuncture, minimal acupuncture at non-acupoints and conventional treatment for chronic sinusitis. DESIGN: A three-armed single blind randomised controlled study. SETTING: In an outpatient specialist clinic, we recruited 65 patients with symptoms of sinusitis >3 months and signs of sinusitis on computed tomography (CT). INTERVENTIONS: We randomised patients to one of three study arms: (1) 2-4 weeks of medication with antibiotics, corticosteroids, 0.9% sodium chloride solution, and local decongestants (n=21), (2) 10 treatments with traditional Chinese acupuncture (n=25), or (3) 10 treatments with minimal acupuncture at non-acupoints (n=19). OUTCOME MEASURES: Change in sinus soft tissue swelling on CT, symptoms of sinusitis, and health-related quality of life (HRQoL), using the two component summary scales of the Short Form 36 and a rating scale. RESULTS: In the conventional treatment group, sinus soft tissue swelling was reduced over 4 weeks (p=0.04), and HRQoL improved over 12 weeks (p=0.01-0.05). Pairwise comparisons of changes in total symptom score between the groups showed signs of a difference between conventional medication and sham over 4 weeks (p=0.06). CONCLUSION: Sinus soft tissue swelling was reduced in the conventional treatment group over 4 weeks, and HRQoL improved over 12 weeks. Only a non-significant difference in symptom score change over 4 and 12 weeks was shown between conventional medication and traditional Chinese acupuncture.


Subject(s)
Acupuncture/methods , Adrenal Cortex Hormones/therapeutic use , Anti-Bacterial Agents/therapeutic use , Sinusitis/therapy , Adult , Chronic Disease , Female , Humans , Male , Pain Measurement , Quality of Life , Sinusitis/drug therapy , Sinusitis/physiopathology , Treatment Outcome
18.
Eur Respir J ; 25(4): 618-25, 2005 Apr.
Article in English | MEDLINE | ID: mdl-15802334

ABSTRACT

Lung function has been associated with mortality after adjusting for other risk factors; however, few studies have adjusted for physical fitness and reported separate analyses according to smoking status. In 1972-1975, spirometry, clinical and physiological parameters were recorded in 1,623 apparently healthy males aged 40-59 yrs. After 26 yrs of follow-up, the current authors investigated the association between baseline lung function and mortality, adjusting for smoking, physical fitness and other potential factors. By 2000, 615 individuals (38%) had died, with 308 (50%) of these deaths from cardiovascular (CV) causes. Forced expiratory volume in one second was a predictor of all-cause mortality (risk ratio (RR) 1.10 per reduction of 10%) after adjusting for smoking, physical fitness, age, systolic blood pressure, body mass index and serum cholesterol. The corresponding multivariate RR was 1.07 for CV causes and 1.34 for respiratory death. In conclusion, in stratified analyses among current and former smokers, forced expiratory volume in one second % predicted was a strong independent predictor of all-cause mortality and respiratory death among current smokers. Forced expiratory volume in one second % predicted was not associated with mortality among never-smokers.


Subject(s)
Lung/physiopathology , Smoking/adverse effects , Adult , Cardiovascular Diseases/etiology , Cardiovascular Diseases/mortality , Follow-Up Studies , Humans , Male , Middle Aged , Smoking/mortality , Time Factors
19.
Clin Radiol ; 59(11): 1018-24, 2004 Nov.
Article in English | MEDLINE | ID: mdl-15488851

ABSTRACT

AIMS: To assess the quality of the imaging procedure requests and radiologists' reports using an auditing tool, and to assess the agreement between different observers of the quality parameters. MATERIALS AND METHODS: In an audit using a standardized scoring system, three observers reviewed request forms for 296 consecutive radiological examinations, and two observers reviewed a random sample of 150 of the corresponding radiologists' reports. We present descriptive statistics from the audit and pairwise inter-observer agreement, using the proportion agreement and kappa statistics. RESULTS: The proportion of acceptable item scores (0 or +1) was above 70% for all items except the requesting physician's bleep or extension number, legibility of the physician's name, or details about previous investigations. For pairs of observers, the inter-observer agreement was generally high, however, the corresponding kappa values were consistently low with only 14 of 90 ratings >0.60 and 6 >0.80 on the requests/reports. For the quality of the clinical information, the appropriateness of the request, and the requested priority/timing of the investigation items, the mean percentage agreement ranged 67-76, and the corresponding kappa values ranged 0.08-0.24. CONCLUSION: The inter-observer reliability of scores on the different items showed a high degree of agreement, although the kappa values were low, which is a well-known paradox. Current routines for requesting radiology examinations appeared satisfactory, although several problem areas were identified.


Subject(s)
Medical Records/standards , Radiology/standards , Humans , Medical Audit , Norway , Observer Variation
20.
Acta Neurol Scand ; 109(4): 244-9, 2004 Apr.
Article in English | MEDLINE | ID: mdl-15016005

ABSTRACT

OBJECTIVES: To assess predictors of outcome of temporal lobectomy for intractable epilepsy. MATERIAL AND METHODS: In 63 adult patients operated with anterior temporal lobectomy during 198892, we used logistic regression analysis to assess predictors of being seizure-free (Engel's class I) 2 years after surgery. As potential predictors, we included the following variables: gender, age at operation, age at onset of seizures, epilepsy duration, etiology, generalized vs not generalized seizures, seizure frequency, intelligence quotient, ictal electroencephalography, magnetic resonance imaging (MRI), single-photon emission computed tomography (SPECT), side of resection, and extent of the resection. RESULTS: About 44% of the surgery patients were seizure-free (Engel's class I) 2 years after surgery. In multivariate analysis (n = 55), MRI pathology defined as atrophy in the temporal lobe, angioma, tumor or mesial temporal sclerosis (odds ratio, OR 7.4, 95%CI: 1.7-32.9) and extent of the hippocampal resection (increase of 1 cm) (OR 2.2, 95%CI: 1.1-4.6) predicted being seizure-free. CONCLUSION: Focal pathology in preoperative MRI and the extent of the hippocampal resection were the only significant predictors of being seizure-free after 2 years.


Subject(s)
Anterior Temporal Lobectomy , Epilepsies, Partial/surgery , Epilepsy, Generalized/surgery , Adolescent , Adult , Disease-Free Survival , Epilepsies, Partial/pathology , Epilepsies, Partial/physiopathology , Epilepsy, Generalized/pathology , Epilepsy, Generalized/physiopathology , Female , Follow-Up Studies , Humans , Male , Middle Aged , Predictive Value of Tests , Temporal Lobe/pathology , Temporal Lobe/physiopathology , Temporal Lobe/surgery , Treatment Outcome
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