Microbiological substantiation of the effectiveness of quercitin and its combination with ethylmethylhydroxypyridine succinate in the complex treatment of odontogenic phlegmon and maxillofacial abscesses.

Odontogenic infections can become life-threatening. The aim of the study was to determine the effectiveness of quercitin and its combination with ethylmethylhydroxypyridine succinate in the complex treatment of odontogenic infections by assessing the microbial population of the infection site. Materials and methods: The cross-sectional study included 75 patients. Purulent exudate was collected from the infection site. The number of colony-forming units was counted using the standard plate method. Results: The microbiological examination of purulent exudate obtained from the patients revealed the general prevalence of Gram-positive cocci. On the seventh day of treatment, the total number of microorganisms in the purulent exudate of patients in group I, whose treatment included a combination of the standard protocol with quercitin, significantly decreased compared to the first day of the same group. The results of treatment of patients in group II, which included the standard protocol in combination with quercitin and 2-ethyl-6-methyl-3-hydroxypyridine succinate, demonstrate a significant decrease in the total number of bacteria in the infection focus on the fifth day of treatment compared to this indicator of the group at the beginning of the study. Conclusions: When quercitin was used as part of complex treatment, the total treatment period was reduced by 1.4 days. However, the combined use of quercitin and ethylmethylhydroxypyridine succinate against the background of standard treatment of patients with odontogenic infection contributed to a reduction in hospital stay by 2 days.

Perspectives for applying the additional study methods for diagnostics optimization of postoperative hypertrophic scars of the head and neck.

OBJECTIVE: Introduction: The issue of improving the quality of diagnosis, prevention and treatment of patients with pathological scarring of the head and neck is being actively developed throughout the world. The aim of the research is to improve diagnostics of hypertrophic scars of the head and neck through the establishment of structural features of scar-modified tissues using RGB-system and ultrasound examination. PATIENTS AND METHODS: Materials and methods: In this study, 60 patients with hypertrophic scars of the head and neck were examined. Under our supervision, there were patients in whom the type of scar was previously confirmed clinically and morphologically. RESULTS: Results: Based on the optical analysis of the obtained images, it can be concluded that hypertrophic scars are well visualized and are different from intact skin. We created a standardized table of numerical values for distribution of color components in the RGB system. Analyzing the data as for the numerical differences in terms of echogenicity of hypertrophic scars, we found that the echogenicity changes in the area of medial and lateral edges of the scar had significant differences. CONCLUSION: Conclusions: A comprehensive examination of patients with hypertrophic scarring of the head and neck, which implies the mandatory use of RGB-visualization and ultrasound examination, enables us to differentiate the type of scar tissue. The described comprehensive approach to examination of patients with scarring will provide the optimal choice of methods for treatment.