Subject(s)
Cromolyn Sodium/therapeutic use , Fenoterol/therapeutic use , Lung Diseases, Obstructive/drug therapy , Product Surveillance, Postmarketing , Aerosols , Cromolyn Sodium/administration & dosage , Cromolyn Sodium/adverse effects , Drug Combinations , Fenoterol/administration & dosage , Fenoterol/adverse effects , Humans , Lung Diseases, Obstructive/physiopathologyABSTRACT
In the treatment of chronic obstructive airway diseases, the inhalative application of medicaments with a bronchodilatory effect is given preference throughout the world. In addition to inhalation solutions and powder capsules, so-called metered-dose aerosols have formed an established part of the treatment plan for approximately 30 years now. With the piezoelectric inhalation device, a fully portable ultrasonic atomiser that is small enough to fit within the pocket, has been developed for the first time. In this device, the piezoelectric effect is utilised to produced, pressure-free, microfine aerosols. Within it, an accurately metered volume containing the therapeutic dose is applied to an atomising element oscillating in the ultrasonic range. The particle spectrum generated with the piezo-system corresponds, in terms of size, to that of metered aerosol devices, and the mean particle diameter is approximately 2.1 microns. The atomisation process takes approximately one second.
Subject(s)
Fenoterol/administration & dosage , Lung Diseases, Obstructive/drug therapy , Respiratory Therapy/instrumentation , Aerosols , Double-Blind Method , Humans , Lung Volume Measurements , Randomized Controlled Trials as TopicABSTRACT
For eight days 8 healthy volunteers were treated with a formula diet and additional 1680 purine base per day. Beginning with day 5, doqualast was administered orally in a dosage of 200 mg t.i.d. Serum uric acid level was lowered by doqualast from 7.84 +/- 0.9 mg/dl to 5.09 +/- 0.8 mg/dl (p less than 0.01). Uric acid clearance increased from 7.6 +/- 2.5 ml/min to 11.5 +/- 2.4 ml/min (p less than 0.05). Excretion of uric acid in urine increased from 622 +/- 231 mg/d to 890 +/- 233 mg/d at the end of therapy. Total cholesterol in serum was lowered from 222 +/- 70 mg/dl to 159 +/- 48 mg/dl (p less than 0.05). The new uric acid lowering drug doqualast was well tolerated clinically. No adverse effects on biochemistry parameters were observed.