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Chem Commun (Camb) ; 51(34): 7379-81, 2015 Apr 30.
Article in English | MEDLINE | ID: mdl-25825211

ABSTRACT

We show that nucleotides which are modified with a G-quadruplex-derived DNAzyme are substrates for DNA polymerases. Based on this finding we developed a naked-eye detection system that allows the detection of single nucleotide variations in DNA.


Subject(s)
DNA, Catalytic/chemistry , DNA, Catalytic/metabolism , DNA-Directed DNA Polymerase/metabolism , G-Quadruplexes , Nucleotides/metabolism , Benzothiazoles/chemistry , Biocatalysis , Biosensing Techniques , Models, Molecular , Oxidation-Reduction , Polymorphism, Single Nucleotide , Sulfonic Acids/chemistry
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