ABSTRACT
OBJECTIVES: The objective of this study is to report on the performance of the MRI-guided VABB in our center and to look at the long-term outcome of biopsies with benign histology over a period of 19 years. METHODS: In a single-center retrospective review study, data of 600 VABB procedures performed between September 1999 and March 2017 were evaluated. We collected patient demographics, histopathological diagnosis at MRI-VABB, and basic lesion characteristics (size, location). Data from the Belgian Cancer Registry was cross-referenced with our database to find out which patients with benign MRI-VABB results developed a malignant lesion over time. RESULTS: These 600 VABB procedures were performed in 558 women with a mean patient age of 51.8 years (range 18-82 years). Our technical success rate was 99.3%. We found 27.67% B5 lesions, 9.82% B3 lesions, and 0.17% B4 lesions. Of 362 benign MRI-guided VABBs, follow-up data was available for a mean follow-up period of 7.6 years (0.8-18.3). Only one (0.3%) biopsy was a false negative lesion after MRI-guided VABB during follow-up. Short-term FU-MRI provided no increase in detection rate. CONCLUSION: The accuracy of MRI-guided VABB is high with a very low false negative rate of 0.3% on long-term follow-up. The value of short-term FU-MRI for every case after MRI-guided VABB may be questioned. KEY POINTS: ⢠MRI-guided vacuum-assisted breast biopsies yield a large portion of clinically relevant lesions (9.82% B3, 0.17% B4, and 27.67% B5 lesions). ⢠The false negative biopsy rate of MRI-guided VABB in this study with a mean follow-up time of 7.6 years was only 0.3%. ⢠Performing a short-term follow-up MRI after a benign MRI-guided VABB concordant to the MRI appearance may be questioned.
Subject(s)
Breast Neoplasms , Image-Guided Biopsy , Adolescent , Adult , Aged , Aged, 80 and over , Biopsy , Breast/diagnostic imaging , Breast Neoplasms/diagnostic imaging , Female , Humans , Magnetic Resonance Imaging , Middle Aged , Retrospective Studies , Vacuum , Young AdultSubject(s)
Hepatitis/diagnosis , Q Fever/diagnosis , Skin Ulcer/diagnosis , Anti-Bacterial Agents/therapeutic use , Doxycycline/therapeutic use , Hepatitis/drug therapy , Hepatitis/pathology , Humans , Liver/pathology , Male , Middle Aged , Q Fever/drug therapy , Skin/pathology , Skin Ulcer/drug therapy , Skin Ulcer/pathologyABSTRACT
This is the second well documented case of paraneoplastic Cushing's syndrome arising from a small cell carcinoma of the endometrium described in English literature. This tumour has an aggressive biological behaviour and early detection provides the only opportunity for long-term survival. In that regard recognition of associated paraneo- plastic features might be helpful.
