Cisto dentígero: diagnóstico e tratamento / Cisto dentígero: diagnosis and treatment / Cisto dentígero: diagnóstico y tratamiento

O cisto dentígero é um cisto odontogênico que é classificado como de desenvolvimento. Normalmente, está relacionado à coroa de um dente incluso, sendo um dos cistos odontogênicos mais frequentes nos ossos gnáticos. Na maioria das vezes é diagnosticado em pacientes entre a segunda e a terceira década de vida, com grande ocorrência em terceiros molares inferiores e caninos superiores. Clinicamente, apresenta evolução lenta, assintomática e pode causar discreta deformidade facial, deslocamento de dentes e alterações de estruturas na região. Radiograficamente, os cistos dentígeros são descritos como lesões radiolúcidas bem delimitadas e uniloculares. Na maioria dos casos, são observados em exames de rotina ou durante a pesquisa da causa da não erupção de um dente permanente. Apesar da singularidade clínica de cada caso, o prognóstico dessa lesão é favorável. O tratamento para o cisto dentígero pode ser a marsupialização em casos de lesões grandes, enucleação com exodontia do dente incluso ou preservação do elemento dental. Este trabalho visa apresentar um caso clínico de cisto dentígero em região posterior de mandíbula, abordando aspectos clínicos, imaginológicos, histopatológicos e terapêuticos, com a finalidade de familiarizar o cirurgião dentista com tal lesão(AU)

The dentigerous cyst is an odontogenic cyst that is classified as developmental cyst. It is usually related to the crown of an included tooth, being one of the most frequent odontogenic cysts in the gnatic bones. Most of the time it is diagnosed in patients between the second and third decade of life, with great occurrence in third molars and upper canines. Clinically, it presents slow evolution, asymptomatic and can cause discreet facial deformity, tooth dislocation and alterations of structures in the region. Radiographically, dentigerous cysts are described as well delimited and unilocular radiolucent lesions. Normally, they are seen in routine examinations or during the investigation of the cause of non-eruption of a permanent tooth. Despite the clinical singularity of each case, the prognosis of this lesion is favorable. The treatment for dentigerous cyst may be marsupialization in cases of large lesions, enucleation with exodontia of the included tooth or preservation of the dental element. This paper aims to present a case report of a dentigerous cyst in the mandible, posterior region, addressing clinical, imaging, histopathological and therapeutic aspects, in order to familiarize the dentist surgeon with such lesion(AU)

El quiste dentígero es un quiste odontogénico que se clasifica como de desarrollo. Normalmente, esta relacionada con la corona de un diente incluido, siendo uno de los quistes odontogénicos más frecuentes en los huesos gnáticos. La mayoría de las veces se diagnostica en pacientes entre la segunda y la tercera década de vida, con gran ocurrencia en terceros molares inferiores y caninos superiores. Clínicamente, presenta evolución lenta, asintomática y puede causar discreta deformidad facial, desplazamiento de dientes y cambios de estructuras en la región. Los cistos dentígeros se describen como lesiones radiolúcidas bien delimitadas y uniloculares. Normalmente, se observan en exámenes de rutina o durante la investigación de la causa de la no erupción de un diente permanente. A pesar de la singularidad clínica de cada caso, el pronóstico de esta lesión es favorable. El tratamiento para el quiste dentígero puede ser la marsupialización en casos de lesiones grandes, enucleación con exodoncia del diente incluido o preservación del elemento dental. Este trabajo pretende presentar un relato de caso clínico de quiste dentígero en mandíbula, región posterior, abordando aspectos clínicos, imaginológicos, histopatológicos y terapéuticos, con la finalidad de familiarizar al cirujano dentista con tal lesión(AU)

Uncommon Occurrence of Lip Squamous Cell Carcinoma in a Pediatric Patient.

Although head and neck squamous cell carcinoma represents one of the most common cancers among adults, it is rare in pediatric patients. The purpose of this report is to discuss the case of a 15-year-old male patient referred by his dentist due to a three-month old ulcer in his lower lip. The patient denied tobacco smoking and drinking alcohol, and confirmed that he performed manual labor in a brick yard, being exposed daily to the sun without protection. Clinical examination revealed an exophytic rounded ulcer in the right lower lip, measuring 1.5 cm, with a flaky bed. An incisional biopsy was performed, and histopathologic analysis confirmed the diagnosis of squamous cell carcinoma. The treatment of choice was surgical excision. Malignancy should be included in the differential diagnosis of chronic oral ulcers in children and adolescents. Moreover, chronic sun exposure might be associated with occurrence of lip squamous cell carcinoma.

Correlation between METAVIR scores and Raman spectroscopy in liver lesions induced by hepatitis C virus: a preliminary study.

The viral hepatitis C is one of the most important causes of chronic hepatic illness worldwide, affecting around 3 % of the world population. Raman spectroscopy has been employed to distinguish normal from hepatic lesions through differences in the spectral features related to the METAVIR score system. This preliminary study evaluated 11 patients with diagnoses of chronic hepatitis C who underwent hepatic biopsies; the biopsies were submitted to near-infrared Raman spectroscopy using a dispersive spectrometer (830-nm wavelength, 300-mW laser power, and 20-s exposure time). The METAVIR was further scored, and the spectra were submitted to principal component analysis (PCA). The results show a good correlation between the Raman spectroscopy features and the stage of hepatic inflammation and fibrosis. PCA showed that samples with a higher degree of fibrosis presented a higher amount of protein features (collagen), whereas samples with a higher degree of inflammation presented higher features of hemoglobin, in accordance to the expected evolution of chronic hepatitis. Quinone was found to be an important biomarker in early hepatic lesions with a spectral feature at 1595 cm(-1). This study demonstrates that Raman spectroscopy may become an important tool for diagnosing liver disease.

Alterações renais em diabetes mellitus do tipo 2 descrição da histologia em estudo de necrópsia / Renal disease in type 2 diabetes mellitus a renal histological description in autopsies

Introdução: As alterações histológicas renais encontráveis no paciente com Diabetes Mellitus do tipo 2 (DM2) ainda não estão bem estabelecidas, comoo foram aquelas do diabetes tipo l. Acreditamos que esse fato se deve, em parte, à indicação de biópsia renal em DM2 que se restringe aos casos commanifestações clínicas atípicas, como proteinúria nefrótica, função renal comprometida sem retinopatia ou rápida progressão para insuficiência renal.Objetivos: Descrever as alterações da histologia renal presentes em pacientes diabéticos tipo 2 submetidos à necrópsia após óbito por qualquer causa.Métodos: Análise histológica renal pela microscopia comum de 61 rins de humanos diabéticos necropsiados num período de dez anos (janeiro de 1994 ajaneiro de 2004), no Hospital Universitário em Londrina-PR. Resultados: Dos 61 casos analisados, a glomeruloesclerose diabética clássica, comproliferação nodular, se fez presente em tão somente 49,2%, encontrando-se doença glomerular superimposta à glomeruloesclerose diabética em 6,6%,alterações crônicas com predomínio vascular em 13,1% e outra doença glomerular isolada em 31,1%. Discussão: À semelhança de nossos resultados,em três outros estudos também nos rins obtidos por necrópsias em DM2 houve predomínio da nefroesclerose diabética, por vezes associada a outraspatologias renais. Em nosso material de estudo, 44,2% dos casos apresentavam lesão não diabética composta por outra glomerulopatia em 31,1% enefroesclerose hipertensiva em 13,1%. Conclusões: A análise histológica de rins de pacientes com DM2, obtida por necrópsia, encontra-se emconsonância com os dados da literatura mundial. A biópsia renal em diabéticos com nefropatia certamente permitirá reconhecer, nesse contexto, patologiaseventualmente curáveis.

Background: The structural lesions associated with the signs and symptoms of renal disease in type 2 diabetes mellitus are not as well defined as thoseof type 1; the literature refers to findings other than the typical glomerulosclerosis, but the true prevalence of lesions remains to be established. In general,there is a restrictive biopsy policy in the diabetic patient, indicated only in the presence of heavy proteinuria or renal dysfunction with the absence of retinalchanges. Methods: in the department of pathology of our University Hospital we examined by light microscopy the renal tissue of 61 diabetic type 2 patientswho died from different causes to assess the presence and type of renal changes. Results: 30/61 (49.2%) of the patients had classical diabeticglomerulosclerosis; concomitant diabetic lesion and glomerulonephritis was present in 6.6%;isolated glomerulonephritis in 31.1% and predominant vasculardamage in 1.,1%. Discussion: In our study as well as in three other published studies regarding renal autopsy findings of type 2 diabetic patients, almosthalf of the cases presented a non- classic diabetic glomerular lesion and was represented by hypertensive nephrosclerosis or a potentially curableglomerulonephritis. Conclusions: Our findings with respect to the autopsied diabetic type 2 renal histology are in accordance with the medical literature.Prospectively unrestricted kidney biopsy of type 2 diabetic patients should be stimulated to establish the causes of the renal dysfunction and find treatablelesions, thus enabling us to prevent deterioration is some cases.