1.
Spectrochim Acta A Mol Biomol Spectrosc
; 81(1): 666-71, 2011 Oct 15.
Article
in English
| MEDLINE
| ID: mdl-21778103
ABSTRACT
A series of chalcone derivatives (1-4) were studied. The interaction between these ligands and calf thymus DNA was studied with UV-vis spectrophotometry, fluorescence and circular dichroism spectroscopy. The binding constants K were estimated at 0.5-4.6×10(5) M(-1). All these measurements indicated that the compounds behave as effective DNA-intercalating agents. Electrophoretic separation proved that ligands inhibited topoisomerase I at a concentration of 60 µM.