Vitiligo Possibly Triggered by COVID-19 Vaccination.

Several cutaneous manifestations following COVID-19 vaccination have been cited in the literature since the beginning of the pandemic. Two case reports regarding the development of vitiligo after receiving the COVID-19 vaccine. Herein, we present a case report of a patient who developed new-onset vitiligo two weeks after receiving her COVID-19 vaccine. Although the pathogenesis is unclear, it may be related to the inflammatory cells involved in both the pathogenesis of vitiligo and the mechanism by which the COVID-19 vaccine stimulates the immune system. This case report highlights the need for further investigation into the link between COVID-19 and the development of vitiligo.

Erythrodermic Psoriasis Exacerbated by Bupropion.

Erythroderma is a rare, potentially life-threatening presentation of psoriasis that can be triggered by medication reactions. Bupropion is indicated for major depressive disorder (Wellbutrin®, GlaxoSmithKline, Research Triangle Park, NC), smoking cessation (Zyban®, GlaxoSmithKline, Research Triangle Park, NC), and weight loss (when in formulation with naltrexone ER; Contrave®, Orixegen Therapeutics, La Jolla, CA). Bupropion can exacerbate psoriasis, however, this is an under-recognized side effect of the medication, particularly in the United States. We report a case of bupropion-induced erythrodermic psoriasis in a 62-year-old female who was prescribed the medication for depression. Due to the common comorbidities of depression, obesity, and tobacco abuse in psoriatic patients, all for which treatment with bupropion is indicated, it is important for physicians to be aware of the potential for a life-threatening medication reaction in this patient population.

Neutrophilic dermatosis of the dorsal hands in an elderly man.

recently diagnosed with stage II lung adenocarcinoma, who presented to the clinic with a 14-day history of painful macules that progressed to bullae on the dorsal surface of his hands; decreased range of motion was noted. Examination revealed bilateral small, tender violaceous vesicopustules admixed with larger tense hemorrhagic pus-filled bullae on the dorsal aspect of his hands. Biopsy demonstrated changes consistent with neutrophilic dermatosis of the dorsal hands. The patient had been diagnosed with ulcerative colitis in the 1970s, although the condition was asymptomatic at the time of presentation. Treatment with prednisone 60 mg daily resulted in significant improvement by the next day. This regimen was continued for two weeks and was followed by a 6-week steroid taper. After a review of the approximate 75 cases currently reported, we also discuss the recurrence rate of NDDH of approximately 10%.

A case of self-healing juvenile cutaneous mucinosis.

IMPORTANCE: Self-healing juvenile cutaneous mucinosis is a very rare, self-limiting disease characterized by the abrupt onset of asymptomatic papules and nodules located primarily on the face and periarticular regions of a juvenile patient. There have been less than 20 cases reported since it was first described in 1973. OBSERVATIONS: Most cases have been reported in children 15 years and younger. Herein we present a case affecting a 17-year-old. To our knowledge, this the oldest reported patient with this condition in the USA. CONCLUSIONS AND RELEVANCE: Despite the rarity of this disease, it is important to keep SHJCM on the differential in pediatric patients presenting with proliferating papules and nodules. Knowledge of this entity may prevent unnecessary diagnostic testing and aggressive treatment in the pediatric population with this self-limited disease.