ABSTRACT
41 cases with scarring alopecia seen from 1979 to 1983 were analyzed and differentiated. After exclusion of 7 cases with lichen planopilaris, of 5 cases with discoid lupus erythematosus, of 2 cases with scleroderma, and of 1 case with folliculitis decalvans, there remained 26 cases. The clinical histological and direct immunofluorescence (DIF) findings in these patients suggest that pseudopelade of Brocq might be a distinct disease unrelated to other known types of scarring alopecia. The histopathology is characteristic, and shows the following features: little or only moderate lymphocytic infiltrate, absence of significant follicular plugging, and absence or decrease of sebaceous glands. DIF is negative, occasionally only IgM can be found at the basement membrane. The course of the disease is slowly progressive (in spite of little or no visible erythema), becoming eventually stationary after several years and resulting in a more or less severe permanent hair loss.
Subject(s)
Alopecia/pathology , Scalp/pathology , Adolescent , Adult , Aged , Alopecia/immunology , Cicatrix/pathology , Diagnosis, Differential , Female , Humans , Immunoglobulins/analysis , Male , Middle AgedABSTRACT
A 24-year-old female patient was treated for many years for "verrucae vulgares". Signs of porokeratosis were found by microscopy. Her medical history, the distribution of the hyperkeratotic-verruciform lesions and the characteristic histology features permitted the diagnosis to be made of porokeratosis plantaris, palmaris et disseminata.
Subject(s)
Keratoderma, Palmoplantar/pathology , Adult , Biopsy , Diagnosis, Differential , Female , Humans , Keratoderma, Palmoplantar/genetics , Skin/pathologyABSTRACT
A patient is reported who had a monosymptomatic, cutaneous form of histiocytosis X. The reactivity of cutaneous histiocytosis-X cells with monoclonal anti-T-6 antibody is discussed as a new diagnostic procedure.
Subject(s)
Histiocytosis, Langerhans-Cell/diagnosis , Aged , Cytoplasmic Granules/ultrastructure , Diagnosis, Differential , Histiocytes/ultrastructure , Histiocytosis, Langerhans-Cell/pathology , Humans , Immunoenzyme Techniques , Langerhans Cells/ultrastructure , Leukocytes/ultrastructure , Male , Microscopy, ElectronABSTRACT
A case of squamous cell carcinoma is presented that developed within a tense, fibrotic scar caused by chronic discoid lupus erythematosus. The carcinoma appeared in a woman of 60 years of age who has had chronic discoid lupus erythematosus on the scalp for 30 years. According to the literature, the frequency of this type of malignant transformation is estimated to be within the same range as the incidence of squamous cell carcinomas arising within tense, fibrotic scars, that is ranging between 0.1% and 2.6%. Therefore, no additional carcinoma-promoting factors of different origin specific for chronic discoid lupus erythematosus could be found.
