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Synthetic dihydropacidamycin antibiotics: a modified spectrum of activity for the pacidamycin class.
Bioorg Med Chem Lett
; 13(19): 3305-9, 2003 Oct 06.
Article
in English
| MEDLINE
| ID: mdl-12951115
ABSTRACT
Dihydropacidamycins having an antibacterial spectrum modified from that of the natural product pacidamycins and mureidomycins have been synthesized. Synthetic dihydropacidamycins with noteworthy antibacterial activity against wild-type and resistant Escherichia coli have been identified (MIC=4-8 microg/mL). Some dihydropacidamycins are shown to have activity against multi-resistant clinical strains of Mycobacterium tuberculosis. Compounds of this class are inhibitors of the cell wall biosynthetic enzyme, MraY.