ABSTRACT
We report a case of prostatic cancer in which transformation from adenocarcinoma into small cell carcinoma was demonstrated both by histology and immunohistochemistry. This phenomenon supports the hypothesis that small cell carcinoma of the prostate originates from multipotential prostatic epithelial cells.
Subject(s)
Adenocarcinoma/pathology , Carcinoma, Small Cell/pathology , Cell Transformation, Neoplastic/pathology , Prostate-Specific Antigen/blood , Prostatic Neoplasms/pathology , Adenocarcinoma/diagnosis , Adenocarcinoma/therapy , Biopsy, Needle , Carcinoma, Small Cell/diagnosis , Carcinoma, Small Cell/therapy , Combined Modality Therapy , Epithelium/pathology , Fatal Outcome , Humans , Male , Middle Aged , Prostate/pathology , Prostatic Neoplasms/diagnosis , Prostatic Neoplasms/therapyABSTRACT
We report the case of a patient who, 9 months after initiation of enalapril and hydrochlorothiazide combination treatment for hypertension, developed angio-oedema with near fatal outcome. Our patient was successfully intubated using a flexible bronchofiberoscope. This case demonstrates that patients given an angiotensin-converting enzyme (ACE) inhibitor may develop serious facial and laryngeal swelling even several months after the initiation of treatment. The occurrence of even mild swelling should lead to prompt cessation of the drug. Patients with incipient ACE inhibitor-related angio-oedema should, without any delay, be referred to hospital for emergency treatment.
