ABSTRACT
The use of two silicon carbide plates is reported for the preparation of three libraries of organic molecules using microwave heating. In addition, a preliminary study has been carried out, showing that one of the plates can also be used in a proteomics setting. Both the 24-position and 48-position plates heated evenly when irradiated with microwave energy. The 48-position plate was used to prepare a library of N-aryl functionalized beta-amino esters via an aza-Michael reaction between anilines and Michael acceptors. The 24-position plate was used to prepare a library of biaryls via a Suzuki coupling methodology and a library of 1,4-dihydropyridines via a Hantzsch synthesis. The 48-position plate was also used to perform the proteolytic digestion of insulin chain B by trypsin.
Subject(s)
Carbon Compounds, Inorganic/chemistry , Combinatorial Chemistry Techniques/instrumentation , Silicon Compounds/chemistry , Small Molecule Libraries/chemical synthesis , Amines/chemical synthesis , Amines/chemistry , Animals , Cattle , Dihydropyridines/chemical synthesis , Dihydropyridines/chemistry , Equipment Design , Esters/chemical synthesis , Esters/chemistry , Hydrocarbons, Aromatic/chemical synthesis , Hydrocarbons, Aromatic/chemistry , Insulin/metabolism , Microwaves , Proteomics/instrumentation , Small Molecule Libraries/chemistry , Temperature , Trypsin/metabolismABSTRACT
The lipase-catalysed transesterification reaction of methyl acetoacetate in toluene as a solvent has been studied using carefully controlled conditions. Results suggest that microwave heating does not have a noticeable effect on reaction rate or product conversion.
