Venlafaxine induced acute myocardial infarction with normal coronary arteries.

We describe the case of a 51-year-old female with no risk factors for coronary artery disease who had an episode of a non-ST-elevation myocardial infarction in association with an overdose of Venlafaxine. Cardiac catheterization revealed normal coronary arteries. Because no other obvious exacerbating factors for ischemia were observed, we assume that this drug may have contributed to the development of an acute ischemic event because of its pharmacologic properties.

Molar Refractivity and Connectivity Index Correlations for Henry's Law Virial Coefficients of Odorous Sulfur Compounds on Carbon and for Gas-Chromatographic Retention Indices.

Gas-solid chromatography was used to obtain values of the second gas-solid virial coefficient, B(2s), in the temperature range from 392 to 511 K for 10 volatile, malodorous organic sulfur compounds; ethanethiol, 1-propanethiol, methyl sulfide, 2-propanethiol, 1-methyl-1-propanethiol, 2-methyl-1-propanethiol, 2-methyl-2-propanethiol, ethyl sulfide, ethyl methyl sulfide, and tert-butyl methyl sulfide. Carbopack C (Supelco Inc.), a graphitized carbon black powder, was used as the adsorbent. Beginning with a theoretical equation for the second gas-solid virial coefficient, it was shown how a quantitative structure-retention relation (QSRR) could be developed to correlate ln B(2s) and hence chromatographic retention times with calculated molar refractivity and connectivity index values for the thiols and thioethers. It was found that both the gas-solid interaction energies and the ln B(2s) values could be correlated with calculated adsorbate molar refractivity (r(2)=0.951) and (r(2)=0.961), respectively. Connectivity index and molar refractivity together provide a r(2)=0.989 correlation of the ten ln B(2s) values at 403 K. A set of 373 organic compounds with retention indices taken from the literature was used to further test our approach. The 373 molecules were divided into 10 structural subgroups and molar refractivities and connectivity indices were calculated and used to correlate their retention index values. An overall correlation of r(2)=0.982 for the retention indices of the 373 molecules was found. Copyright 2001 Academic Press.