ABSTRACT
BACKGROUND: Although evidence suggests relationships between some crude oil components and glycemic dysregulation, no studies have examined oil spill-related chemical exposures in relation to type 2 diabetes mellitus (DM) risk. This study examined the relationship between total hydrocarbon (THC) exposure among workers involved in the 2010 Deepwater Horizon (DWH) oil spill and risk of DM up to 6 years afterward. METHODS: Participants comprised 2660 oil-spill cleanup or response workers in the prospective GuLF Study who completed a clinical exam and had no self-reported DM diagnosis prior to the spill. Maximum THC exposure was estimated with a job-exposure matrix based on interview data and personal measurements taken during cleanup operations. We defined incident DM by self-reported physician diagnosis of DM, antidiabetic medication use, or a measured hemoglobin A1c value ≥ 6.5%. We used log binomial regression to estimate risk ratios (RRs) for DM across ordinal categories of THC exposure. The fully adjusted model controlled for age, sex, race/ethnicity, education, employment status, and health insurance status. We also stratified on clinical body mass index categories. RESULTS: We observed an exposure-response relationship between maximum daily ordinal THC exposure level and incident DM, especially among overweight participants. RRs among overweight participants were 0.99 (95% CI: 0.37, 2.69), 1.46 (95% CI: 0.54, 3.92), and 2.11 (95% CI: 0.78, 5.74) for exposure categories 0.30-0.99 ppm, 1.00-2.99 ppm, and ≥3.00 ppm, respectively (ptrend = 0.03). CONCLUSION: We observed suggestively increasing DM risk with increasing THC exposure level among overweight participants, but not among normal weight or obese participants.
Subject(s)
Diabetes Mellitus, Type 2 , Occupational Exposure , Petroleum Pollution , Water Pollutants, Chemical , Humans , Diabetes Mellitus, Type 2/chemically induced , Diabetes Mellitus, Type 2/epidemiology , Gulf of Mexico , Hydrocarbons/analysis , Overweight , Petroleum Pollution/adverse effects , Prospective Studies , Water Pollutants, Chemical/analysisABSTRACT
Primordial germ cells (PGCs) are the founder cells of the gametes. In mammals, PGCs migrate from the hindgut to the genital ridges, where they coalesce with each other and with somatic cells to form the primary sex cords. We show here that, in both sexes, PGCs express P- and E-cadherins during and after migration, and N-cadherin at post-migratory stages. E-Cadherin is not expressed by PGCs whilst in the hindgut, but is upregulated as they leave. Blocking antibodies against E-, but not P-cadherin cause defective PGC-PGC coalescence, and in some cases, ectopic PGCs.
Subject(s)
Cadherins/physiology , Cell Movement/physiology , Germ Cells/physiology , Animals , Cadherins/biosynthesis , Female , Gonads , Male , Mice , Mice, TransgenicABSTRACT
Simultaneous pancreas-kidney (SPK) transplantation has rarely been performed in the pediatric population. This report describes successful SPK transplantation in a 12-year-old girl and a 14-year-old boy with renal and pancreatic insufficiency secondary to postdiarrheal hemolytic-uremic syndrome. All reported cases of pediatric SPK transplantation are reviewed. SPK transplantation is a feasible option in selected pediatric patients with combined pancreatic and renal insufficiency.
Subject(s)
Hemolytic-Uremic Syndrome/surgery , Kidney Transplantation , Pancreas Transplantation , Adolescent , Child , Diabetes Mellitus, Type 1/complications , Female , Humans , MaleABSTRACT
This paper documents exposure to stainless steel welding fumes at a petrochemical plant. The situation evaluated may be separated into three categories: 1) evaluation of background concentration levels in a maintenance shop (area monitoring), 2) evaluation of personnel exposures during open air welding in a maintenance shop (personal monitoring), 3) evaluation of personnel exposures in confined space welding (personal monitoring). Thirty-five area samples and seventy-six personal samples were collected and analyzed for chromium (VI), total chromium, nickel, iron, copper, and total particulates. The background concentrations in the maintenance shop were found to be far below those felt to be harmful. Personnel exposures found in the maintenance shop during open air welding were also low, especially when compared to current OSHA permissible exposure levels. Contaminant levels found during confined space welding, as in distillation towers, were considered excessive. After several possible solutions to the problem were considered, it was decided to implement a mandatory air-line respirator program for all employees entering confined spaces during stainless steel welding operations.
