[Membrane lipids of brush border of the rat small intestine as affected by ionizing radiation]. / Lipidy membran shchitkovoï obliamivky tonkoho kishechnyka pislia vplyvu na shchuriv ionizuiuchoï radiatsiï.

It was established that single total X-ray irradiation in the doses of 0.1; 0.4; 1.0; 2.0; 3.0 and 6.0 Gy 24 hours after irradiation results in reliable changes in membrane lipids composition of brush border of enterocytes in doses over 1.0 Gy. By this changes under increase of dosage of irradiation it were marked differences in comparison with control in lipid-protein, total phospholipids-protein, cholesterol-protein and cholesterol-total phospholipids rations. In lipid composition major changes are connected with increase of lysophosphatidylcholine and lysophosphatidylethanolamine concentrations, decrease of sphingomyelin content and increase of that of phosphatidylethanolamine. Content of cholesterol and free fatty acids decreased reliably under irradiation in doses over 1.0 Gy as well. Data obtained proves that structural-functional properties of brush border membranes of enterocytes of small intestine are altered under irradiation in doses ranging from 1.0 to 6.0 Gy. Lower doses (0.1; 0.4) cause only trend of changes named above.

[The isolation and determination of different narcotic and drug substances after the acid hydrolysis of biological material. (1)]. / Izolirovanie i opredelenie razlichnykh narkoticheskikh i lekarstvennykh veshchestv posle kislotnogo gidroliza biologicheskogo materiala (soobshchenie 1).

A modified method for isolation of toxicologically significant substances after acid hydrolysis of biological material is proposed. Drugs and narcotics of different groups were identified, which are not disintegrated after acid hydrolysis of biological material and are isolated in high amounts.

[The comparative characteristics of the transmembrane ionic currents and the caffeine-induced responses of the smooth-muscle cells in the normal jejunum and under ionizing radiation exposure]. / Sravnitel'naia kharakteristika transmembrannykh ionnykh tokov i kofeinindutsirovannykh otvetov gladkomyshechnykh kletok toshchei kishki v norme i pri vozdeistvii ioniziruiushchei raidatsii.

A comparative investigation of transmembrane ion currents and caffeine-induced responses of single smooth muscle cells isolated from the circular layer of rat small intestine was carried out by the method of "patch-clamp". No reliable difference in potential-dependent and amplitude-kinetic characteristics of transmembrane ion currents in cells of intact and irradiated with dose of 3 Gy rats was revealed. In cells of irradiated animals external application of caffeine (4 mM) was not accompanied by strong quick-inactivated transient Ca(2+)-dependent potassium current as in control. The results obtained suggest that single whole-body X-ray irradiation with dose of 3 Gy does not lead in 5 days to any reliable alteration of potential-controlled channels of rat small intestine smooth muscle cell plasma membranes causing at the same time the disturbance of Ca-binding function of intracellular pools.

[Effects of irradiation on fatty acid structure of membrane lipids of the sarcoplasmic reticulum]. / Deistvie rentgenovskogo izlucheniia na zhirno-kislotnyi sostav lipidov membran sarkoplazmaticheskogo retikuluma.

It has been shown that single local X-irradiation (0.21 C/kg) of the rabbit hind limb in the early period of acute radiation injury (1 and 14 h) causes a decrease in saturation of sarcoplasmic reticulum membrane lipids. It is mainly connected with a decreased saturation of the total fraction of phosphatidyl serine, phosphatidyl inositol and phosphatidyl choline. The above changes can increase permeability of the sarcoplasmic reticulum membranes for Ca(2+)-ion after X-irradiation.

[Surgical treatment of bilateral retinal detachment in aphakia and the efficacy of prophylactic measures]. / Khirurgicheskoe lechenie dvustoronnei otsloiki setchatki pri afakii i éffektivnost' profilakticheskikh meropriiatii.

Analysis of the immediate and late results of surgery for bilateral detachment of the retina in aphakia performed on 58 eyes of 44 patients has shown that the retina stays adhered to the pigmented epithelium after surgery in 63.79% of patients but later is again detached in half the patients, and the share of good late results is but 37.95%. The authors consider the efficacy of prophylactic measures, cryoretinopexy and silicon band circlage, carried out in three groups of patients. Group 1 (320 eyes) consisted of patients in whom cryopexy was performed on myopic eyes before cataract extraction; 1.9% of patients developed detachment of retina, this being 3.5 times less than in the reference group (6.7%). Group 2 (61 eyes) patients were subjected to cryopexy on the second eye if the retina was detached on the first eye; 5.56% of patients developed detachment of retina. Prophylactic circlage was carried out in Group 3 (17 eyes); none of the patients developed detachment of the retina over the follow-up period of 5 years. In the reference group, consisting of similar patients, 16 (21.05%) of the 76 patients developed detachment of retina on the second eye in periods of 2 months to 5 years after surgery. These results demonstrate the usefulness of prophylactic measures in cases with the risk factors.

[The content of phospholipids and free fatty acids in the sarcoplasmic reticulum membranes in the early stage of an x-ray radiation lesion]. / Soderzhanie fosfolipidov i svobodnykh zhirnykh kislot v membrannakh sarkoplazmaticheskogo retikuluma na rannem étape porazheniia rentgenovskim izlucheniem.

One and 24 h following single X-irradiation (0.21 C/kg) of rabbit hind leg the content of free fatty acids and phospholipid lysoforms increased in the sarcoplasmic reticulum (SR) membrane of skeletal muscles. The results obtained are important in estimating the mechanisms of action of ionizing radiation on the structural and functional properties of SR.

[The toxicologic characteristics of a new SAKAP-based benzyl benzoate ointment]. / Toksikologicheskaia kharakteristika novoi mazi benzilbenzoata na osnove SAKAP.

The formula of a new stable 20% benzylbenzoate emulsion is presented, so are the results of studies on its toxicity, local irritating and sensitizing effects in guinea pigs. For comparison, the same characteristics of currently used 20% water-soap benzylbenzoate emulsion and of the new ointment base, SAKAP (acryl copolymer), have been examined. Both the ointment and its base have proved to be safe.

[Electrogenic activity of Ca2+-ATPase fragments of the sarcoplasmatic reticulum during the early stages of radiation injury]. / Elektrogennaia aktivnost' Ca2+-ATPazy fragmentov sarkoplazmaticheskogoretikuluma na rannem étape ostrogo luchevogo porazheniia.

It is established that local X-ray irradiation of the rabbit hind limb produces a decrease in Ca2+, Mg2+-ATP-dependent formation of electric potentials difference on the membrane of the sarcoplasmic reticulum (SR). These results agree with the observed decrease in the Ca2+-ATPase activity of SR membranes and increase in their electric conduction after irradiation.

[Ionic permeability of sarcoplasmic reticulum membranes damaged by x-rays]. / Ionnaia pronitsaemost' membran sarkoplazmaticheskogo retikuluma pri porazhenii rentgenovskim izlucheniem.

As early as 1 and 24 h following single local X-irradiation (0.21 C/kg) of rabbit hindlimbs an increase was noted in the permeability of skeletal muscle sarcoplasmic reticulum membranes for Ca2+, K+ and Na+. The effect was maximum 1 h after irradiation and more pronounced for K+ and Na+ than Ca2+.