[Pathogenetic role of prostanoids in disorders of sodium reabsorption during development of acute renal insufficiency]. / Patohenetychne znachennia prostanoïdiv u porushenni reabsorbtsiï ioniv natriiu za umov rozvytku hostroï nyrkovoï nedostatnosti.

The experiments were carried out on 36 male rats with an acute renal insufficiency--sublimate-induced nephropathy. An increased amount of both tromboxan A2, and prostaglandine F2a has been shown to play a pathogenic role in the disorders of the main energy-dependent process in kidney--reabsorbtion of sodium ions. The negative correlative relation between the concentration of sodium ions in plasma and an increased amount of prostaglandine E2 in a kidney papilla can be explained by the hyperfunction of the interstitial cells of a kidney papilla and with a natriuretic effect of prostaglandine E2 at the level of collective tubules.