Subject(s)
Balneology , Radiation Injuries/blood , Sulfhydryl Compounds/radiation effects , Accidents, Occupational , Child , Evaluation Studies as Topic , Humans , Nuclear Reactors , Power Plants , Radiation Injuries/epidemiology , Radiation Injuries/rehabilitation , Risk Factors , Sulfhydryl Compounds/blood , Ukraine/epidemiologyABSTRACT
Two new pesticide preparations of cyclophos and alvison, a number of their components, two alvison metabolites have been studied to reveal their cytogenetic activity. According to the investigation in vivo the mutagenic effect of cyclophos manifests itself only with toxic doses. Professional contacts with the pesticide don't induce chromosome mutation in human peripheral lymphocytes. The alvison preparations generate chromosome mutations in somatic cells of people and animals. The components and metabolites of alvison have shown no visible genetic activity during in vivo and in vitro experiments.
Subject(s)
Chromosome Aberrations/genetics , Herbicides/toxicity , Insecticides/toxicity , Mutagens , Polyphosphates/toxicity , Sulfones/toxicity , Animals , Herbicides/metabolism , Humans , Insecticides/metabolism , Mice , Occupational Exposure , Polyphosphates/metabolism , Sulfones/metabolismABSTRACT
Investigation of a cytogenetic activity of the insecticide carbofuran and its three main metabolites formed in the mammals' organisms and in the environmental objects showed that the initial substance and two intermediate products of its biotransformation (3-hydroxycarbofuran and 3-keto-carbofuran) induced a clastogenic effect in the culture of human peripheral lymphocytes in vitro. The end metabolite (3-keto-7-phenol) had no mutagenic effect in vitro. The data obtained give evidence for disappearance of the carbofuran mutagenicity in the course of its biotransformation in mammals.
