[The methodology of complex social hygienic investigation of various groups of population and families (In memoriam of professor O. V. Grinina)].

The article expounds main principal positions of professor O. V. Grinina scientific educational methodological school of social hygienic investigations of health of population and family. The methodological analysis of scientific works of professor O. V. Grinina and her disciples was implemented to demonstrate key positions and results of studies constituting scientific school of program methodological basics of complex social hygienic studies of population health, health care and conditions of life of families. The purpose of publication is to characterize indications of the school of complex social hygienic investigations of priority population groups and families. These issues are covered by thematic fundamental works substantiating patterns of formation and estimation of health of families, program methodological issues of complex medical social studies of family and its individual members, availability of large group за disciples developing priority issues of investigation of population health at the level of family and organization of medical care based on the principles of per family observations, general (family) medical practice. The results are demonstrated and patterns are established containing in implemented complex social hygienic per family studies of various population groups, women, children and families in 1970s-1990s. The methodological significance of valid family-focused technologies in new social economic conditions of development of society and health care and principles of curative preventive activities in conditions of mandatory medical insurance are demonstrated. The professor O. V. Grinina substantiated and developed program of medical social characteristic of family. its sections and methodology of long-term continuous monitoring of family. She also determined characteristics of health of family as a group patient, principles of work of out-patient physicians with families directly at the polyclinic district.

[Latent autoimmune diabetes of adults (LADA): The informative value of autoantibodies]. / Latentnyi autoimmunnyi diabet vzroslykh: informativnost' autoantitel.

AIM: To investigate the prevalence of autoantibodies (autoAbs) associated with the development of type 1 diabetes mellitus (T1DM) in latent autoimmune diabetes of adults (LADA) in the Russian Federation. SUBJECTS AND METHODS: A total of 96 patients (46 women and 50 men) with LADA were examined. All the patients underwent an immunological examination including the determination of autoAbs, such as glutamic acid decarboxylase autoAbs (GADA), islet antigen-2 auto-Abs (IA-2A), islet cell cytoplasmic auto-Abs (ICA), zinc transporter 8 auto-Abs (ZnT8A), and insulin auto-Abs (IAA). RESULTS: GADAs were found in 61.5% of the examinees. ICAs were detected in 24%, IA-2As were observed in 57.3%. AutoAbs were more frequently observed in combination than alone. IAAs were least commonly seen in 8.3% and only in combinations. ZnT8As were found in 52.1% of the examinees and they were present alone in 5.2%. CONCLUSION: The antibodies that are most frequently observed in LADA are GADAs, IA-2As and ZnT8As. It is insufficient to identify only GADAs, as the latter are found in only 61.5% of the patients. IA-2As and ZnT8As, which are present in 57.3% and 52.1% of the patients, respectively, should also be used in the diagnosis of LADA. ICAs are much less commonly seen and along with IAAs may be additional markers for LADA.

[Health and the sociomedical needs of the young family]. / Zdorov'e i mediko-sotsial'nye potrebnosti molodoi sem'i.

Results of a comprehensive socio-hygienic examination of a young family with a baby aged under one are analyzed. The authors disclose the notion of the reproductive function and health of a woman in connection with childbirth, upbringing of children, and meeting the basic requirements of an infant under one in medical care and in creation of an environment needed by such an infant. The authors present an assessment of the readiness of a young family to childbirth and upbringing of children, analyze the role of a mother in the formation of the health status of her children and of a family as a whole, and classify the families by their readiness to childbirth and to upbringing of children a relationship between the behaviour of a young mother and her child's health and quality of care of a child in a family is analyzed. The authors come to a conclusion that medicosocial requirements of a young family are governed by familial structure, health of af couple, baby's health, behaviour of a young family, and the communal conditions.

[The role of family in providing harmonious development of children]. / Rol' sem'i v obespechenii garmonichnogo razvitiia detei.

The study results on young families with children aged 0-5 are presented. The first group included 345 families having children with perinatal risk factors. The second group comprised 900 young families which had no violations in children's care but couldn't provide the necessary level of their upbringing and medical care. The disease frequency and distribution of children by health groups in the studied families were analyzed. It was shown that not only risk factors but also behavioral ones had significant impact on the health status of the children aged 0-5.