Peripheral stimulation affects subthreshold Triple Stimulation Technique.

BACKGROUND: Compared to conventional transcranial magnetic stimulation (TMS), the triple stimulation technique (TST) strongly decrease the effects of desynchronization of descending discharges and accompanying phase cancellation that follow TMS and offers a more sensitive method to quantify motor evoked potentials (MEPs). NEW METHOD: Using the TST, we explored as to whether sub-threshold TMS evokes peripheral motor neuron discharges (MNs). We compared the number of MEPs elicited by TMS and by TST in fifteen healthy participants. We used the subthreshold intensity of 80 % resting motor threshold. To control the TST assessment of the corticospinal tract, we included a peripheral stimulation control condition, which consisted of peripheral stimulation alone, in a subgroup of five volunteers. RESULTS: Compared to TMS, TST at sub-threshold intensities did not detect significantly more responses unequivocally attributable to the cortical stimulation. In contrast, the peripheral supra-maximal stimuli produced confounding effects in the TST condition that were, in part, indistinguishable from cortical responses. COMPARISON WITH EXISTING METHODS: At subthreshold TMS intensities, the TST does not detect more discharges of spinal MNs than conventional TMS and, in addition, it is confounded by effects from peripheral stimulation. CONCLUSION: The TST can be useful in assessing the integrity of the MN pool and of the corticospinal tract. However, if used at near threshold intensity, the confounding effects of peripheral stimulation need to be considered; for instance, in paired-pulse stimulation paradigms assessing the cortical physiology.

Event-Related Potentials Measured From In and Around the Ear Electrodes Integrated in a Live Hearing Device for Monitoring Sound Perception.

Future hearing devices could exploit brain signals of the user derived from electroencephalography (EEG) measurements, for example, for fitting the device or steering signal enhancement algorithms. While previous studies have shown that meaningful brain signals can be obtained from ear-centered EEG electrodes, we here present a feasibility study where ear-EEG is integrated with a live hearing device. Seventeen normal-hearing participants were equipped with an individualized in-the-ear hearing device and an ear-EEG system that included 10 electrodes placed around the ear (cEEGrid) and 3 electrodes spread out in the concha. They performed an auditory discrimination experiment, where they had to detect an audible switch in the signal processing settings of the hearing device between repeated presentations of otherwise identical stimuli. We studied two aspects of the ear-EEG data: First, whether the switches in the hearing device settings can be identified in the brain signals, specifically event-related potentials. Second, we evaluated the signal quality for the individual electrode positions. The EEG analysis revealed significant differences between trials with and without a switch in the device settings in the N100 and P300 range of the event-related potential. The comparison of electrode positions showed that the signal quality is better for around-the-ear electrodes than for in-concha electrodes. These results confirm that meaningful brain signals related to the settings of a hearing device can be acquired from ear-EEG during real-time audio processing, particularly if electrodes around the ear are available.

Adapting Hearing Devices to the Individual Ear Acoustics: Database and Target Response Correction Functions for Various Device Styles.

To achieve a natural sound quality when listening through hearing devices, the sound pressure at the eardrum should replicate that of the open ear, modified only by an insertion gain if desired. A target approximating this reference condition can be computed by applying an appropriate correction function to the pressure observed at the device microphone. Such Target Response Correction Functions (TRCF) can be defined based on the directionally dependent relative transfer function between the location of the hearing device microphone and the eardrum of the open ear. However, it is unclear how exactly the TRCF should be derived, and how large the benefit of individual, versus generic, correction is. We present measurements of Head-Related Transfer Functions (HRTF) at the eardrum and at 9 microphone locations of a comprehensive set of 5 hearing device styles, including 91 incidence directions, and recorded in 16 subjects and 2 dummy heads. Based on these HRTFs, individualized and generic TRCF were computed for frontal (referred to as free-field) and diffuse-field sound incidence. Spectral deviations between the computed target and listening with the open ear were evaluated using an auditory model and virtual acoustic scenes. Results indicate that a correction for diffuse-field incidence should be preferred over the free field, and individual correction functions result in notably reduced spectral deviations to open-ear listening, as compared with generic correction functions. These outcomes depend substantially on the specific device style. The HRTF database and derived TRCFs are publicly available.

Non-invasive brain stimulation of motor cortex induces embodiment when integrated with virtual reality feedback.

Previous evidence highlighted the multisensory-motor origin of embodiment - that is, the experience of having a body and of being in control of it - and the possibility of experimentally manipulating it. For instance, an illusory feeling of embodiment towards a fake hand can be triggered by providing synchronous visuo-tactile stimulation to the hand of participants and to a fake hand or by asking participants to move their hand and observe a fake hand moving accordingly (rubber hand illusion). Here, we tested whether it is possible to manipulate embodiment not through stimulation of the participant's hand, but by directly tapping into the brain's hand representation via non-invasive brain stimulation. To this aim, we combined transcranial magnetic stimulation (TMS), to activate the hand corticospinal representation, with virtual reality (VR), to provide matching (as contrasted to non-matching) visual feedback, mimicking involuntary hand movements evoked by TMS. We show that the illusory embodiment occurred when TMS pulses were temporally matched with VR feedback, but not when TMS was administered outside primary motor cortex, (over the vertex) or when stimulating motor cortex at a lower intensity (that did not activate peripheral muscles). Behavioural (questionnaires) and neurophysiological (motor-evoked-potentials, TMS-evoked-movements) measures further indicated that embodiment was not explained by stimulation per se, but depended on the temporal coherence between TMS-induced activation of hand corticospinal representation and the virtual bodily feedback. This reveals that non-invasive brain stimulation may replace the application of external tactile hand cues and motor components related to volition, planning and anticipation.

Binaural model-based dynamic-range compression.

OBJECTIVE: Binaural cues such as interaural level differences (ILDs) are used to organise auditory perception and to segregate sound sources in complex acoustical environments. In bilaterally fitted hearing aids, dynamic-range compression operating independently at each ear potentially alters these ILDs, thus distorting binaural perception and sound source segregation. DESIGN: A binaurally-linked model-based fast-acting dynamic compression algorithm designed to approximate the normal-hearing basilar membrane (BM) input-output function in hearing-impaired listeners is suggested. A multi-center evaluation in comparison with an alternative binaural and two bilateral fittings was performed to assess the effect of binaural synchronisation on (a) speech intelligibility and (b) perceived quality in realistic conditions. STUDY SAMPLE: 30 and 12 hearing impaired (HI) listeners were aided individually with the algorithms for both experimental parts, respectively. RESULTS: A small preference towards the proposed model-based algorithm in the direct quality comparison was found. However, no benefit of binaural-synchronisation regarding speech intelligibility was found, suggesting a dominant role of the better ear in all experimental conditions. CONCLUSION: The suggested binaural synchronisation of compression algorithms showed a limited effect on the tested outcome measures, however, linking could be situationally beneficial to preserve a natural binaural perception of the acoustical environment.

Hearing aid fitting and fine-tuning based on estimated individual traits.

OBJECTIVE: A generalised concept for hearing aid fitting and fine-tuning based on estimated individual traits is presented along first implementations in this report. DESIGN: To estimate the individual traits, a set of auditory model-based performance measures is used to generate promising candidates within the algorithm's parameter space for a subsequent subjective rating. For the subjective assessment, a fast and intuitive multi-stimulus test denoted as combined discrimination and classification (CoDiCl) is presented to capture user preferences for an optimised setting. STUDY SAMPLE: The estimation of individual traits is shown in an exemplary manner for a multidimensional coherence-based noise reduction algorithm. The dimensionality reduction was performed using differently weighted combinations of speech intelligibility index (SII) and perceived similarity measure (PSM). RESULTS: Nine reasonable alternative algorithm setting candidates were extracted from a model-optimised exploration path (MOEP) for a subsequent subjective rating to potentially differentiate between listeners with different attitudes towards noise suppression and introduced distortions (i.e. "noise haters" and "distortion haters"). CONCLUSIONS: By iteratively improving the agreement between subjective and objective assessment, an objective estimation of subjective traits using appropriate weightings of objective measures may become possible. This will potentially help to efficiently fit modern multidimensional hearing aid algorithms to the individual user.

An individualised acoustically transparent earpiece for hearing devices.

OBJECTIVE: An important and often still unresolved problem of hearing devices such as assistive listening devices and hearing aids is limited user acceptance - a primary reason is poor conservation quality of the acoustic environment. Approaching a possible solution to this problem, an earpiece prototype is presented and evaluated. The prototype is individually and automatically calibrated in situ to provide acoustical transparency, i.e., achieving an audio perception alike to the open ear. DESIGN: A comprehensive evaluation was performed, comprising technical measurements on an advanced dummy head and listening tests, in which listeners directly compared sound perception through the prototype and a simulated open ear canal reference. STUDY SAMPLE: Ten normal hearing subjects, including five expert listeners, participated in the listening test. RESULTS: The technical evaluation verified good achievement of acoustical transparency. The psychoacoustic results showed that a reliable distinction between the two conditions presented was not possible for relevant communication sounds. CONCLUSION: The prototype can be described as an initial realisation of an acoustically transparent hearing system, i.e. a device that does not disturb the perception of external sounds. In further developments, the device can be considered as the basis for systems integrating high sound quality, hearing support and other desired modifications.

Modifications of the MUlti stimulus test with Hidden Reference and Anchor (MUSHRA) for use in audiology.

OBJECTIVE: Two modifications of the standardised MUlti Stimulus test with Hidden Reference and Anchor (MUSHRA), namely MUSHRA simple and MUSHRA drag&drop, were implemented and evaluated together with the original test method. The modifications were designed to maximise the accessibility of MUSHRA for elderly and technically non-experienced listeners, who constitute the typical target group in hearing aid evaluation. DESIGN: Three MUSHRA variants were assessed based on subjective and objective measures, e.g. test-retest reliability, discrimination ability, time exposure and overall preference. With each method, participants repeated the task to rate the quality of several hearing aid algorithms four times. STUDY SAMPLE: Fifty listeners grouped into five subject classes were tested, including elderly and technically non-experienced participants with normal and impaired hearing. Normal-hearing, technically experienced students served as controls. RESULTS: Both modifications can be used to obtain compatible rating results. Both were preferred over the classical MUSHRA procedure. Technically experienced listeners performed best with the modification MUSHRA drag&drop. CONCLUSIONS: The comprehensive comparison of the MUSHRA variants demonstrates that the intuitive modification MUSHRA drag&drop can be generally recommended. However, considering e.g. specific evaluation demands, we suggest a differentiated and careful application of listening test methods.

Desynchronization does not contribute to intracortical inhibition and facilitation: a paired-pulse paradigm study combined with TST.

The paired-pulse (PP) transcranial magnetic stimulation (TMS) paradigms allow the exploration of the motor cortex physiology. The triple stimulation technique (TST) improves conventional TMS by reducing effects of desynchronization of motor neuron discharges allowing a precise evaluation of the corticospinal conduction. The objective of our study was to explore PP TMS paradigms combined with the TST to study whether the desynchronization contributes to these phenomena and whether the combined TMS-TST protocol could improve the consistency of responses. We investigated the PP paradigms of short intracortical inhibition (SICI) with 2 ms interstimulus interval (ISI) and of intracortical facilitation (ICF) with 10 ms ISI in 22 healthy subjects applying either conventional TMS alone or combined with the TST protocol. The results of the PP paradigms combined with the TST of SICI and ICF do not differ from those with conventional TMS. However, combining the PP paradigm with the TST reduces their variability. These results speak against a contribution of the desynchronization of motor neuron discharges to the PP paradigms of SICI and ICF. Combining the PP TMS paradigm with the TST may improve their consistency, but the interindividual variability remains such that it precludes their utility for clinical practice.NEW & NOTEWORTHY Combining the triple stimulation technique with the paired-pulse stimulation paradigm improves the consistency of short intracortical inhibition and facilitation and could be useful in research, but the interindividual variability precludes their utility for clinical practice. Our findings do not suggest that desynchronization of descending discharges following transcranial magnetic stimulation contributes to short intracortical inhibition or intracortical facilitation.

Comparing Binaural Pre-processing Strategies I: Instrumental Evaluation.

In a collaborative research project, several monaural and binaural noise reduction algorithms have been comprehensively evaluated. In this article, eight selected noise reduction algorithms were assessed using instrumental measures, with a focus on the instrumental evaluation of speech intelligibility. Four distinct, reverberant scenarios were created to reflect everyday listening situations: a stationary speech-shaped noise, a multitalker babble noise, a single interfering talker, and a realistic cafeteria noise. Three instrumental measures were employed to assess predicted speech intelligibility and predicted sound quality: the intelligibility-weighted signal-to-noise ratio, the short-time objective intelligibility measure, and the perceptual evaluation of speech quality. The results show substantial improvements in predicted speech intelligibility as well as sound quality for the proposed algorithms. The evaluated coherence-based noise reduction algorithm was able to provide improvements in predicted audio signal quality. For the tested single-channel noise reduction algorithm, improvements in intelligibility-weighted signal-to-noise ratio were observed in all but the nonstationary cafeteria ambient noise scenario. Binaural minimum variance distortionless response beamforming algorithms performed particularly well in all noise scenarios.

Comparing Binaural Pre-processing Strategies III: Speech Intelligibility of Normal-Hearing and Hearing-Impaired Listeners.

A comprehensive evaluation of eight signal pre-processing strategies, including directional microphones, coherence filters, single-channel noise reduction, binaural beamformers, and their combinations, was undertaken with normal-hearing (NH) and hearing-impaired (HI) listeners. Speech reception thresholds (SRTs) were measured in three noise scenarios (multitalker babble, cafeteria noise, and single competing talker). Predictions of three common instrumental measures were compared with the general perceptual benefit caused by the algorithms. The individual SRTs measured without pre-processing and individual benefits were objectively estimated using the binaural speech intelligibility model. Ten listeners with NH and 12 HI listeners participated. The participants varied in age and pure-tone threshold levels. Although HI listeners required a better signal-to-noise ratio to obtain 50% intelligibility than listeners with NH, no differences in SRT benefit from the different algorithms were found between the two groups. With the exception of single-channel noise reduction, all algorithms showed an improvement in SRT of between 2.1 dB (in cafeteria noise) and 4.8 dB (in single competing talker condition). Model predictions with binaural speech intelligibility model explained 83% of the measured variance of the individual SRTs in the no pre-processing condition. Regarding the benefit from the algorithms, the instrumental measures were not able to predict the perceptual data in all tested noise conditions. The comparable benefit observed for both groups suggests a possible application of noise reduction schemes for listeners with different hearing status. Although the model can predict the individual SRTs without pre-processing, further development is necessary to predict the benefits obtained from the algorithms at an individual level.

Frequency difference limens at high frequencies: evidence for a transition from a temporal to a place code.

It is commonly believed that difference limens for frequency (DLFs) for pure tones depend on a temporal mechanism (phase locking) for frequencies up to 4-5 kHz and a place mechanism at higher frequencies. The DLFs predicted from a place mechanism, expressed as a proportion of center frequency (Δf/f), should be approximately invariant with frequency at medium to high frequencies. If there is a transition from a temporal to a place mechanism, Δf/f should increase with increasing center frequency until the transition occurs, and then reach a plateau. Published data do not show such an effect. In this study, DLFs were measured for center frequencies from 2 to 14 kHz, using earphones designed to produce a flat response at the eardrum. The level of every tone was varied over a range of ±4 dB, to reduce loudness cues. The value of Δf/f increased progressively from 2 to 8 kHz, but did not change significantly for frequencies from 8 to 14 kHz. The results are consistent with the idea that there is a transition from a temporal to a place mechanism at about 8 kHz, rather than at 4-5 kHz, as is commonly assumed.

The role of time and place cues in the detection of frequency modulation by hearing-impaired listeners.

Frequency modulation detection limens (FMDLs) were measured for five hearing-impaired (HI) subjects for carrier frequencies f(c) = 1000, 4000, and 6000 Hz, using modulation frequencies f(m) = 2 and 10 Hz and levels of 20 dB sensation level and 90 dB SPL. FMDLs were smaller for f(m) = 10 than for f(m) = 2 Hz for the two higher f(c), but not for f(c) = 1000 Hz. FMDLs were also determined with additional random amplitude modulation (AM), to disrupt excitation-pattern cues. The disruptive effect was larger for f(m) = 10 than for f(m) = 2 Hz. The smallest disruption occurred for f(m) = 2 Hz and f(c) = 1000 Hz. AM detection thresholds for normal-hearing and HI subjects were measured for the same f(c) and f(m) values. Performance was better for the HI subjects for both f(m). AM detection was much better for f(m) = 10 than for f(m) = 2 Hz. Additional tests showed that most HI subjects could discriminate temporal fine structure (TFS) at 800 Hz. The results are consistent with the idea that, for f(m) = 2 Hz and f(c) = 1000 Hz, frequency modulation (FM) detection was partly based on the use of TFS information. For higher carrier frequencies and for all carrier frequencies with f(m) = 10 Hz, FM detection was probably based on place cues.

Effects of sequential streaming on auditory masking using psychoacoustics and auditory evoked potentials.

The present study was aimed at investigating the relationship between the mismatch negativity (MMN) and psychoacoustical effects of sequential streaming on comodulation masking release (CMR). The influence of sequential streaming on CMR was investigated using a psychoacoustical alternative forced-choice procedure and electroencephalography (EEG) for the same group of subjects. The psychoacoustical data showed, that adding precursors comprising of only off-signal-frequency maskers abolished the CMR. Complementary EEG data showed an MMN irrespective of the masker envelope correlation across frequency when only the off-signal-frequency masker components were present. The addition of such precursors promotes a separation of the on- and off-frequency masker components into distinct auditory objects preventing the auditory system from using comodulation as an additional cue. A frequency-specific adaptation changing the representation of the flanking bands in the streaming conditions may also contribute to the reduction of CMR in the stream conditions, however, it is unlikely that adaptation is the primary reason for the streaming effect. A neurophysiological correlate of sequential streaming was found in EEG data using MMN, but the magnitude of the MMN was not correlated with the audibility of the signal in CMR experiments. Dipole source analysis indicated different cortical regions involved in processing auditory streaming and modulation detection. In particular, neural sources for processing auditory streaming include cortical regions involved in decision-making.

Suppression and comodulation masking release in normal-hearing and hearing-impaired listeners.

The detectability of a sinusoidal signal embedded in a masker at the signal frequency can be improved by simultaneously presenting additional maskers in off-frequency regions if the additional maskers and the on-frequency masker component have the same temporal envelope. This effect is commonly referred to as comodulation masking release (CMR). Recently, it was hypothesized that peripheral nonlinear processes such as suppression may play a role in CMR over several octaves when the level of the off-frequency masker component is higher than the level of the on-frequency masker component. The aim of the present study was to test this hypothesis by measuring suppression and CMR within the same subjects for various frequency-level combinations of the off-frequency masker component. Experimental data for normal-hearing listeners show a large overlap between the existence regions for suppression and CMR. Hearing-impaired subjects with a sensorineural hearing loss show, on average, negligible suppression and CMR. The data support the hypothesis that part of the CMR in experiments with large spectral distances and large level differences between the masker components is due to the nonlinear processing at the level of the cochlea.

Mechanisms underlying the detection of frequency modulation.

Frequency modulation detection limens (FMDLs) were measured for carrier frequencies (f(c)) of 1000, 4000, and 6000 Hz, using modulation frequencies (f(m)) of 2 and 10 Hz and levels of 20 and 60 dB sensation level (SL), both with and without random amplitude modulation (AM), applied in all intervals of a forced-choice trial. The AM was intended to disrupt excitation-pattern cues. At 60 dB SL, the deleterious effect of the AM was smaller for f(m) = 2 than for f(m) = 10 Hz for f(c) = 1000 and 4000 Hz, respectively, while for f(c) = 6000 Hz the deleterious effect was large and similar for the two values of f(m). This is consistent with the idea that, for f(c) below about 5000 Hz and f(m) = 2 Hz, frequency modulation can be detected via changes in phase locking over time. However, at 20 dB SL, the deleterious effect of the added AM for f(c) = 1000 and 4000 Hz was similar for the two values of f(m), while for f(c) = 6000 Hz, the deleterious effect of the AM was greater for f(m) = 10 than for f(m) = 2 Hz. It is suggested that, at low SLs, the auditory filters become relatively sharp and phase locking weakens, so that excitation-pattern cues influence FMDLs even for low f(c) and low f(m).

Cortical representation of release from auditory masking.

The aim of the present study was to find a functional MRI correlate in human auditory cortex of the psychoacoustical effect of release from masking, using amplitude-modulated noise stimuli. A sinusoidal target signal was embedded in a band-limited white noise, which was either unmodulated or (co)modulated. Psychoacoustical thresholds were measured for the target signals in both types of masking noise, using an adaptive procedure. The mean threshold difference between the unmodulated and the comodulated condition, i.e., the release from masking, was 15 dB. The same listeners then participated in an fMRI experiment, recording activation of auditory cortex in response to tones in the presence of modulated and unmodulated noise maskers at five different signal-to-noise ratios. In general, a spatial dissociation of changes of overall level and signal-to-noise ratio in auditory cortex was found, replicating a previous fMRI study on pure-tone masking. The comparison of the fMRI activation maps for a signal presented in modulated and in unmodulated noise reveals that those regions in the antero-lateral part of Heschl's gyrus previously shown to represent the audibility of a tonal target (rather than overall level) exhibit a stronger activation for the modulated than for the unmodulated conditions. This result is interpreted as a physiological correlate of the psychoacoustical effect of comodulation masking release at the level of the auditory cortex.

Comodulation masking release for regular and irregular modulators.

The present study investigates whether the difference in comodulation masking release (CMR) for different modulator types is due to the different degrees of modulator regularity, as suggested in the literature, or results from different envelope distributions. Thresholds of a sinusoidal signal are measured in the presence of a noise masker which was either broadband or narrow band. A square-wave modulator with different degrees of regularity is used that preserves the envelope distribution. The measured CMR does not decrease as the regularity decreases. This finding argues against the hypothesis that the difference in CMR for different modulator types reported in the literature is due to differences in regularity. The data for the narrow-band conditions which either mimic the auditory frequency selectivity or preserve the modulation spectrum indicate that most of the CMR of the present study is due to within-channel cues. In agreement with this finding, within-channel models using either a peripheral nonlinearity or a modulation filterbank predict a CMR of a similar size. In contrast to the model predictions and the findings for the narrow-band conditions, the CMR for the broadband masker increases as the regularity decreases. This suggests that the CMR is not solely determined by the envelope distributions.

Spatial dissociation of changes of level and signal-to-noise ratio in auditory cortex for tones in noise.

Functional magnetic resonance imaging has been used to investigate the signal representation in human auditory cortex for a sinusoidal signal in the presence of a noise masker. This paradigm is widely used in auditory research to study auditory processing. Five-note tonal melodies were presented in a masking noise for signal-to-noise ratios (S/N) from -18 dB to+24 dB in 6 dB-steps. For small S/N (-18 dB, -12 dB, -6 dB) the overall level of the sound is nearly constant, but the audibility of the tone varies with S/N. For S/N of 0 dB and above, the tone is always clearly audible, and the perceived change is mainly the increase in overall level. This interaction between S/N, overall level and perception is reflected by a spatial dissociation of the respective activation in auditory cortex. Brain regions mainly sensitive to level changes were found in various parts of the superior temporal lobes, including primary auditory cortex and Planum temporale, while those regions mainly sensitive to S/N changes were located at or close to lateral Heschl's gyrus. The overlap between these two regions is small. The results are interpreted as indicating that the coding of overall level and, thus, loudness is different from the coding of audibility of a periodic signal. The S/N-sensitive region largely overlaps with the pitch-sensitive regions in lateral Heschl's gyrus found in previous studies. The results from the present study further suggest that the audibility of a tone in noise is related to the overall pitch strength.

Peripheral and central aspects of auditory across-frequency processing.

Many natural sounds such as, e.g., speech show common level fluctuations across frequency. It is generally assumed that the auditory system uses this spectro-temporal information to group the frequency components into auditory objects although the exact physiological mechanism is still not fully understood. The aim of the present study is to disentangle the relative contribution of peripheral and central aspects of this across-frequency processing using psychophysical experiments and modelling. The study focuses on two different psychophysical phenomena which are thought to be related to the ability to compare information across frequency: comodulation masking release (CMR), i.e., a release from masking of a sinusoidal signal due to the addition of a comodulated off-frequency masker component to the masker component at the signal frequency, and comodulation detection difference (CDD), i.e., the reduced ability of the auditory system to detect a masked signal if masker and signal share the same envelope. The comparison between model predictions and experimental results indicates that a considerable amount of these effects can be accounted for by peripheral processing alone. This is confirmed by experimental results with confounding across-frequency information about the grouping of the different frequencies into auditory objects.