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Dermatology ; 207(2): 182-4, 2003.
Article in English | MEDLINE | ID: mdl-12920370

ABSTRACT

We report a case of Netherton syndrome manifested as congenital ichthyosiform erythroderma, trichorrhexis invaginata and atopy, who in early adulthood developed multiple, aggressive epithelial neoplasms in sun-exposed areas of the skin, in areas with papillomatous skin hyperplasia and at the left parotid region. The occurrence of cutaneous neoplasia has been reported in syndromes with congenital ichthyosis and suggests that the underlying genetic defects may cause the development of cancer in prone patients.


Subject(s)
Carcinoma, Squamous Cell/pathology , Ichthyosiform Erythroderma, Congenital/complications , Neoplasms, Multiple Primary/pathology , Skin Neoplasms/pathology , Adult , Carcinoma, Squamous Cell/complications , Humans , Male , Skin Diseases, Genetic/complications , Skin Neoplasms/complications , Syndrome
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