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A ribose-functionalized NAD+ with versatile activity for ADP-ribosylation.
Stephens, Elisa N; Zhang, Xiao-Nan; Lam, Albert T; Li, Jiawei; Pei, Hua; Louie, Stan G; Wang, Clay C C; Zhang, Yong.
Chem Commun (Camb) ; 59(93): 13843-13846, 2023 Nov 21.
Article in English | MEDLINE | ID: mdl-37921487

ABSTRACT

An NAD+ featuring an adenosyl 4'-azido functions as a general substrate for poly-ADP-ribose polymerases. Its derived mono- and poly-ADP-ribosylated proteins can be adequately recognized by distinct ADP-ribosylation-specific readers. This molecule represents the first ribose-functionalized NAD+ with versatile activities across different ADP-ribosyltransferases and provides insight into developing new probes for ADP-ribosylation.


Subject(s)
NAD , Ribose , NAD/metabolism , Poly(ADP-ribose) Polymerases/metabolism , ADP Ribose Transferases/chemistry , ADP Ribose Transferases/genetics , ADP Ribose Transferases/metabolism , ADP-Ribosylation
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